scPDB - Distribution of Binding site Similarity values of 1ia4 entry / Site 2

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	1.000
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.759
3qlr	NDP	Dihydrofolate reductase	1.5.1.3	0.517
1ai9	NDP	Dihydrofolate reductase	1.5.1.3	0.512
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.503
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.494
1m78	NDP	Dihydrofolate reductase	1.5.1.3	0.493
1ia1	NDP	Dihydrofolate reductase	1.5.1.3	0.492
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.487
4kne	1CY	Dihydrofolate reductase	1.5.1.3	0.483
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.476
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.474
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.472
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.470
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.468
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.465
5ecc	NAP	Dehydrofolate reductase type I	/	0.465
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.463
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.463
1ra8	FOL	Dihydrofolate reductase	1.5.1.3	0.462
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.462
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.461
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.460
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.455
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.455
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.455
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.451
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.450
1dr2	TAP	Dihydrofolate reductase	1.5.1.3	0.447
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.445
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.445
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.444
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.443
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.443
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.442
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.441
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.441