scPDB - Distribution of Binding site Similarity values of 1ia3 entry / Site 2

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	1.000
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.793
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.521
1m78	NDP	Dihydrofolate reductase	1.5.1.3	0.509
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.495
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.486
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.480
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.478
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.477
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.476
4kne	1CY	Dihydrofolate reductase	1.5.1.3	0.476
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.474
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.474
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.469
4g95	OAG	Dihydrofolate reductase	1.5.1.3	0.466
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.465
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.465
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.465
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.464
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.463
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.462
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.461
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.460
1rx1	NAP	Dihydrofolate reductase	1.5.1.3	0.459
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.459
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.458
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.458
1dr2	TAP	Dihydrofolate reductase	1.5.1.3	0.457
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.456
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.456
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.454
5hi6	MTX	Dihydrofolate reductase	/	0.454
5ecc	NAP	Dehydrofolate reductase type I	/	0.453
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.452
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.452
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.451
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.450
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.450
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
3mdv	CL6	Cholesterol 24-hydroxylase	/	0.446
1bzf	TMQ	Dihydrofolate reductase	1.5.1.3	0.444
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.444
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.444
3dga	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.444
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.443
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.443
1dr3	TAP	Dihydrofolate reductase	1.5.1.3	0.442
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3sgv	2BJ	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.442
3nxx	NDP	Dihydrofolate reductase	1.5.1.3	0.441
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.441
1u71	MXA	Dihydrofolate reductase	1.5.1.3	0.440