sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.680 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.674 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.664 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.642 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.634 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.622 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.618 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.614 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.612 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.609 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.602 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.602 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.591 | |
| 3cse | N22 | Uncharacterized protein | / | 0.579 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.578 | |
| 3qly | 55V | Uncharacterized protein | / | 0.577 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.576 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.575 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.573 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.572 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.571 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.563 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.559 | |
| 3eem | 53V | Uncharacterized protein | / | 0.558 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.552 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.548 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.545 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.545 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.543 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.543 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.542 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.542 | |
| 3eej | 53R | Uncharacterized protein | / | 0.541 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.540 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.537 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.531 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.530 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3eel | 53T | Uncharacterized protein | / | 0.529 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.522 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.517 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.513 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.509 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.508 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.507 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.506 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.506 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.505 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.504 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.503 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.503 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.502 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.502 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.501 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.499 | |
| 4zas | TYD | CalS13 | / | 0.499 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.498 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.497 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.497 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.493 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.492 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.491 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.491 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.491 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.490 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.489 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.489 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.489 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.488 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.487 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.487 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.486 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.486 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.486 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.485 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.484 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.484 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.484 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.483 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.483 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.483 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.482 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.482 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3tgu | WF3 | Cytochrome b | / | 0.481 | |
| 4l8u | 9AZ | Serum albumin | / | 0.481 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.481 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.480 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.480 | |
| 3njo | P2M | Abscisic acid receptor PYR1 | / | 0.480 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.480 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.480 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.480 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.479 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.479 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.478 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.477 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.477 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.476 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.476 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.476 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.475 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.475 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.475 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.475 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.475 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.474 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.474 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.473 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.473 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.473 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.473 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.472 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.472 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.472 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3tdl | 11D | Serum albumin | / | 0.472 | |
| 4egn | TWO | Cytochrome P450 | / | 0.472 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.471 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.471 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.471 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.471 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.471 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.471 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.471 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.471 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.470 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.470 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.470 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.470 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1syn | F89 | Thymidylate synthase | / | 0.469 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.469 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.469 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.468 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.468 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.468 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.468 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.467 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.467 | |
| 1sqb | AZO | Cytochrome b | / | 0.467 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.467 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.467 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.467 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.467 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.467 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.467 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.466 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2g44 | T3O | Estrogen receptor | / | 0.466 | |
| 2p15 | EZT | Estrogen receptor | / | 0.466 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.466 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.466 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.465 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.465 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.464 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.464 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.464 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.464 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.464 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.464 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.464 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.463 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.463 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.463 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.463 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.463 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.463 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.462 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.462 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.462 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.462 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.462 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.462 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.462 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.462 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.462 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.462 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.462 | |
| 4iah | 1DX | Alr2278 protein | / | 0.462 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.462 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.461 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.461 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.461 | |
| 3wgw | T2B | Proliferating cell nuclear antigen | / | 0.461 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.461 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.461 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.461 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 1ysx | 4EB | Serum albumin | / | 0.460 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.460 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.460 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.460 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.460 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.460 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.460 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.460 | |
| 4f1s | F1S | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.459 | |
| 1zky | 689 | Estrogen receptor | / | 0.459 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.459 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.459 | |
| 3l71 | AZO | Cytochrome b | / | 0.459 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.459 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.458 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.457 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.457 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.457 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2zce | PYL | Pyrrolysine--tRNA ligase | / | 0.457 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.457 | |
| 3sr5 | Q12 | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.457 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.457 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.457 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.456 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.456 | |
| 1xj7 | DHT | Androgen receptor | / | 0.456 | |
| 2ejz | SAH | Diphthine synthase | / | 0.456 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.456 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.456 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.456 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.456 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.455 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.455 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.455 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.455 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.455 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.455 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.455 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.455 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.455 | |
| 1fml | RTL | Retinol dehydratase | / | 0.454 | |
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.454 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.454 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.454 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.454 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.454 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.454 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.453 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.453 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.453 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.453 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.453 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.452 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.452 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.452 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3up0 | D7S | aceDAF-12 | / | 0.452 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 4g1q | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.452 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.452 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.451 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.451 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.451 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.451 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.451 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.451 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.451 | |
| 3zbn | COA | 3-ketoacyl-CoA thiolase-like protein | / | 0.451 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.451 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.451 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.450 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.450 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.450 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.450 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.450 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.449 | |
| 1osv | CHC | Bile acid receptor | / | 0.449 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.449 | |
| 2iog | IOG | Estrogen receptor | / | 0.449 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.449 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.449 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.449 | |
| 3zr7 | OR8 | Progesterone receptor | / | 0.449 | |
| 4bew | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.449 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.449 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.449 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.449 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.449 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.449 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.448 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.448 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.448 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.448 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.448 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3cqu | CQU | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.448 | |
| 3dmj | GWE | Pol protein | / | 0.448 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.448 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.448 | |
| 4pd6 | URI | Nucleoside permease | / | 0.448 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.448 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.447 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.447 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2ow3 | BIM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3mfu | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.447 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3qzy | FAD | FAD-linked sulfhydryl oxidase | / | 0.447 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.447 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.447 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.447 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.447 | |
| 4i42 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.447 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.447 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.446 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.446 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.446 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.446 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.446 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.446 | |
| 4ful | 0VU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.446 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.446 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.446 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.446 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 1iky | MSD | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.445 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.445 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3e6o | A55 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.445 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3h1j | SMA | Cytochrome b | / | 0.445 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.445 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4j26 | EST | Estrogen receptor beta | / | 0.445 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.445 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.445 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.445 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.445 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.444 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.444 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.444 | |
| 1tkt | H12 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.444 | |
| 1xpc | AIT | Estrogen receptor | / | 0.444 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.444 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2nr4 | FMN | Conserved protein | / | 0.444 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.444 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3a8w | ATP | Protein kinase C iota type | 2.7.11.13 | 0.444 | |
| 3b99 | U51 | Prostacyclin synthase | / | 0.444 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.444 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.444 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.444 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.444 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.444 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1sqp | MYX | Cytochrome b | / | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2bxo | OPB | Serum albumin | / | 0.443 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.443 | |
| 2j62 | GSZ | O-GlcNAcase NagJ | / | 0.443 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.443 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.443 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3zra | ORB | Progesterone receptor | / | 0.443 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.443 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 4kfb | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.443 | |
| 1lhw | ESM | Sex hormone-binding globulin | / | 0.442 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.442 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.442 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.442 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.442 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.442 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.442 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4dk5 | 0KO | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.442 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.442 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.441 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.441 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 1pp9 | SMA | Cytochrome b | / | 0.441 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.441 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 1rt5 | UC2 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.441 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.441 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3l70 | JZV | Cytochrome b | / | 0.441 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.441 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.441 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.441 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.441 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4boe | CLR | Japanin | / | 0.441 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.441 | |
| 4lvg | 20O | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.441 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.440 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.440 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.440 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 2b1z | 17M | Estrogen receptor | / | 0.440 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.440 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.440 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.440 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3s1s | SAH | Restriction endonuclease BpuSI | / | 0.440 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.440 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.440 | |
| 4iji | 99T | Glutathione S-transferase-like protein YibF | / | 0.440 | |
| 4j6i | 1JV | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 |