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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ht834CProstaglandin G/H synthase 11.14.99.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ht834CProstaglandin G/H synthase 11.14.99.11.000
1eqhFLPProstaglandin G/H synthase 11.14.99.10.662
1eqgIBPProstaglandin G/H synthase 11.14.99.10.631
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.627
3n8wFLPProstaglandin G/H synthase 11.14.99.10.626
3pghFLPProstaglandin G/H synthase 21.14.99.10.606
3n8zFLPProstaglandin G/H synthase 11.14.99.10.591
2aylFLPProstaglandin G/H synthase 11.14.99.10.589
1q4gBFLProstaglandin G/H synthase 11.14.99.10.588
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.586
3ntgD72Prostaglandin G/H synthase 21.14.99.10.584
4coxIMNProstaglandin G/H synthase 21.14.99.10.584
4ph9IBPProstaglandin G/H synthase 21.14.99.10.578
3rr3FLRProstaglandin G/H synthase 21.14.99.10.569
3ln1CELProstaglandin G/H synthase 21.14.99.10.558
2oyuIMSProstaglandin G/H synthase 11.14.99.10.557
3n8xNIMProstaglandin G/H synthase 11.14.99.10.534
3mqe416Prostaglandin G/H synthase 21.14.99.10.530
1ht5FL2Prostaglandin G/H synthase 11.14.99.10.522
3q7dNPXProstaglandin G/H synthase 21.14.99.10.509
4rrxLURProstaglandin G/H synthase 21.14.99.10.505
6coxS58Prostaglandin G/H synthase 21.14.99.10.496
5ikrID8Prostaglandin G/H synthase 21.14.99.10.495
3kk6CELProstaglandin G/H synthase 11.14.99.10.490
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.487
3n8yDIFProstaglandin G/H synthase 11.14.99.10.484
4rrwLURProstaglandin G/H synthase 21.14.99.10.474
4rrzLURProstaglandin G/H synthase 21.14.99.10.474
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.465
4b7dQLECytochrome P450 monooxygenase PikC/0.465
4uz6SCRPalmitoleoyl-protein carboxylesterase NOTUM/0.463
1cbrREACellular retinoic acid-binding protein 1/0.462
4otyLURProstaglandin G/H synthase 21.14.99.10.461
3ln052BProstaglandin G/H synthase 21.14.99.10.459
1xkdNAPIsocitrate dehydrogenase [NADP]/0.458
1wlvCOAPhenylacetic acid degradation protein PaaI/0.456
4o701QKBromodomain-containing protein 4/0.455
3cwkREACellular retinoic acid-binding protein 2/0.453
3vt9YI4Vitamin D3 receptor/0.451
1efpFADElectron transfer flavoprotein subunit alpha/0.450
1ysx4EBSerum albumin/0.450
2p4yC03Peroxisome proliferator-activated receptor gamma/0.450
1iyzNDPProbable quinone oxidoreductase/0.447
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.446
3ttjJBIMitogen-activated protein kinase 102.7.11.240.446
2jn3JN3Fatty acid-binding protein, liver/0.445
4nyeADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.445
2qnqQN3Gag-Pol polyprotein3.4.23.160.444
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
2fzmFADBifunctional protein PutA1.5.5.20.443
1xuoLA1Integrin alpha-L/0.442
2aibERGBeta-elicitin cinnamomin/0.442
4fhi0S4Vitamin D3 receptor A/0.442
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.442
1uzwCDHIsopenicillin N synthase1.21.3.10.441
2qg2A91Heat shock protein HSP 90-alpha/0.441
4qe6JN3Bile acid receptor/0.441
5br4NADLactaldehyde reductase1.1.1.770.440