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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1hpzAAPGag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1hpzAAPGag-Pol polyprotein2.7.7.491.000
1vruAAPGag-Pol polyprotein2.7.7.490.621
1hniAAAGag-Pol polyprotein2.7.7.490.614
3i0rRT3Gag-Pol polyprotein2.7.7.490.594
3is9AC7Gag-Pol polyprotein2.7.7.490.581
4kko1REGag-Pol polyprotein2.7.7.490.578
2ze2T27Gag-Pol polyprotein2.7.7.490.576
4ko0JLJGag-Pol polyprotein2.7.7.490.574
1ikvEFZGag-Pol polyprotein2.7.7.490.569
1hnvTBOGag-Pol polyprotein2.7.7.490.568
1tl1H18Gag-Pol polyprotein2.7.7.490.568
1tkzH16Gag-Pol polyprotein2.7.7.490.567
1hquHBYGag-Pol polyprotein2.7.7.490.563
1tvrTB9Gag-Pol polyprotein2.7.7.490.563
3ffi3OBGag-Pol polyprotein2.7.7.490.562
1tktH12Gag-Pol polyprotein2.7.7.490.559
1tl3H20Gag-Pol polyprotein2.7.7.490.557
3irxUDRGag-Pol polyprotein2.7.7.490.556
3qlhT27Gag-Pol polyprotein2.7.7.490.545
2vg7NNIGag-Pol polyprotein2.7.7.490.544
4i7fNVEGag-Pol polyprotein2.7.7.490.544
1revTB9Gag-Pol polyprotein2.7.7.490.542
4id5T27Gag-Pol polyprotein2.7.7.490.542
1ikwEFZGag-Pol polyprotein2.7.7.490.541
4i2q1BTGag-Pol polyprotein2.7.7.490.541
1rt4UC1Gag-Pol polyprotein2.7.7.490.538
4ig3T27Gag-Pol polyprotein2.7.7.490.538
1s1wUC1Gag-Pol polyprotein2.7.7.490.536
1c1bGCAGag-Pol polyprotein2.7.7.490.535
2zd1T27Gag-Pol polyprotein2.7.7.490.535
1s9eADBGag-Pol polyprotein2.7.7.490.534
1rt5UC2Gag-Pol polyprotein2.7.7.490.533
3i0sRT7Gag-Pol polyprotein2.7.7.490.533
4i2pG73Gag-Pol polyprotein2.7.7.490.533
2rf2MRXGag-Pol polyprotein2.7.7.490.530
1rt2TNKGag-Pol polyprotein2.7.7.490.529
1eetBFUGag-Pol polyprotein2.7.7.490.525
1s6qTPBGag-Pol polyprotein2.7.7.490.525
1ikyMSDGag-Pol polyprotein2.7.7.490.524
3lamKRPGag-Pol polyprotein2.7.7.490.521
1fk9EFZGag-Pol polyprotein2.7.7.490.520
5cyqT27Gag-Pol polyprotein2.7.7.490.519
4g1qT27Gag-Pol polyprotein2.7.7.490.518
1rt7UC4Gag-Pol polyprotein2.7.7.490.516
3megT27Gag-Pol polyprotein2.7.7.490.515
3nbpJGZGag-Pol polyprotein2.7.7.490.512
1ikxPNUGag-Pol polyprotein2.7.7.490.510
2vg5NNCGag-Pol polyprotein2.7.7.490.509
1ep4S11Gag-Pol polyprotein2.7.7.490.508
3lanKBTGag-Pol polyprotein2.7.7.490.507
2ic3HBYGag-Pol polyprotein2.7.7.490.505
1s1tUC1Gag-Pol polyprotein2.7.7.490.503
3med65BGag-Pol polyprotein2.7.7.490.501
2opqHBQGag-Pol polyprotein2.7.7.490.500
2opsHBQGag-Pol polyprotein2.7.7.490.499
3meeT27Gag-Pol polyprotein2.7.7.490.499
1jlaTNKGag-Pol polyprotein2.7.7.490.496
3dleGFAGag-Pol polyprotein2.7.7.490.494
3m8qDJZGag-Pol polyprotein2.7.7.490.494
1jlqSBNGag-Pol polyprotein2.7.7.490.493
1tkxGWBGag-Pol polyprotein2.7.7.490.493
3di6PDZGag-Pol polyprotein2.7.7.490.491
3m8p65BGag-Pol polyprotein2.7.7.490.489
1c1c612Gag-Pol polyprotein2.7.7.490.488
2ban357Gag-Pol polyprotein2.7.7.490.488
2hnzPC0Gag-Pol polyprotein2.7.7.490.488
1jlgUC1Gag-Pol polyprotein2.7.7.490.484
2zjwREFCasein kinase II subunit alpha2.7.11.10.482
1rtiHEFGag-Pol polyprotein2.7.7.490.481
2vu3LZECyclin-dependent kinase 22.7.11.220.480
1s1vTNKGag-Pol polyprotein2.7.7.490.478
3dmjGWEPol protein/0.478
1rt1MKCGag-Pol polyprotein2.7.7.490.474
2hndNVPGag-Pol polyprotein2.7.7.490.473
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.472
3wv9FEGHmd co-occurring protein HcgE/0.471
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.471
4a32MYAGlycylpeptide N-tetradecanoyltransferase/0.470
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.465
4b14NHWGlycylpeptide N-tetradecanoyltransferase/0.465
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.465
1jlcFTCGag-Pol polyprotein2.7.7.490.464
4a30MYAGlycylpeptide N-tetradecanoyltransferase/0.464
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.464
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.464
3mec65BGag-Pol polyprotein2.7.7.490.463
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.463
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
5ag6MYAGlycylpeptide N-tetradecanoyltransferase/0.463
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.462
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.460
3dolGWIPol protein/0.459
4b12NHWGlycylpeptide N-tetradecanoyltransferase/0.459
4h9614QDihydrofolate reductase1.5.1.30.459
4o761M3Bromodomain-containing protein 4/0.459
1klmSPPGag-Pol polyprotein2.7.7.490.458
3abaFLICytochrome P450/0.458
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.458
1o5rFR9Adenosine deaminase3.5.4.40.457
5ag7MYAGlycylpeptide N-tetradecanoyltransferase/0.457
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
4y8wSTRSteroid 21-hydroxylase/0.456
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.455
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.455
4bfxZVXPantothenate kinase2.7.1.330.455
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2ittAEEEpidermal growth factor receptor2.7.10.10.453
2fvdLIACyclin-dependent kinase 22.7.11.220.452
3u4uLNHCasein kinase II subunit alpha2.7.11.10.452
1v7aFRCAdenosine deaminase3.5.4.40.450
3d75NBBPheromone-binding protein ASP1/0.450
3gc9B45Mitogen-activated protein kinase 112.7.11.240.450
5cvfATPCasein kinase II subunit alpha2.7.11.10.449
1fkoEFZGag-Pol polyprotein2.7.7.490.448
2po7CHDFerrochelatase, mitochondrial4.99.1.10.448
2q59240Peroxisome proliferator-activated receptor gamma/0.448
4g7gVFVLanosterol 14-alpha-demethylase/0.447
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.447
4kfbT27Gag-Pol polyprotein2.7.7.490.447
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1fmjRTLRetinol dehydratase/0.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3opdHIEHeat shock protein 83/0.445
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.445
4o71CPBBromodomain-containing protein 4/0.445
5uviZMAAdenosine receptor A2a/0.445
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2cciATPCyclin-dependent kinase 22.7.11.220.444
3c6tM14Gag-Pol polyprotein2.7.7.490.444
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.444
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3dhoB2MStreptogramin A acetyltransferase2.3.10.443
3qtuX44Cyclin-dependent kinase 22.7.11.220.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
1cqp803Integrin alpha-L/0.442
4bfsZVSPantothenate kinase2.7.1.330.442
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.442
4jq8KJ8Epidermal growth factor receptor2.7.10.10.442
3e01PZ2Gag-Pol polyprotein2.7.7.490.441
3le62BZCyclin-dependent kinase 22.7.11.220.441
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
3rmf20ZCyclin-dependent kinase 22.7.11.220.441
3sw418KCyclin-dependent kinase 22.7.11.220.441
3vt7VDXVitamin D3 receptor/0.441
2oppHBQGag-Pol polyprotein2.7.7.490.440
4ii5ADPCyclin-dependent kinase 22.7.11.220.440
4xwtU5PRibonuclease J/0.440