scPDB - Distribution of Binding site Similarity values of 1hfr entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1hfr	MOT	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	1.000
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.619
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.601
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.594
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.589
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.587
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.586
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.582
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.572
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.561
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.558
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.550
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.547
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.545
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.536
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.532
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.529
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.529
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.525
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.520
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.515
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.512
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.510
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.508
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.508
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.508
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.506
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.502
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.500
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.498
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.497
1u70	MTX	Dihydrofolate reductase	1.5.1.3	0.494
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.489
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.486
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.484
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.482
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.481
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.475
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.473
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.473
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.468
3k45	51P	Dihydrofolate reductase	1.5.1.3	0.466
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.464
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.458
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.457
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.457
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.454
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.447
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.440
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440