scPDB - Distribution of Binding site Similarity values of 1hfp entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1hfp	MOT	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	1.000
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.660
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.579
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.568
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.539
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.533
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.528
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.526
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.525
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.520
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.517
1pd8	CO4	Dihydrofolate reductase	1.5.1.3	0.509
3nxt	D2E	Dihydrofolate reductase	1.5.1.3	0.509
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.507
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.506
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.505
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.498
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.498
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.497
3cse	N22	Uncharacterized protein	/	0.496
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.496
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.494
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.491
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.490
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.490
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.488
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.486
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.485
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.482
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.482
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.480
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.479
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.478
2w3v	TOP	Dihydrofolate reductase	/	0.477
3qlz	QLZ	Uncharacterized protein	/	0.477
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.477
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.476
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.476
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.476
4m6k	FOL	Dihydrofolate reductase	1.5.1.3	0.476
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.475
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.475
1mvs	DTM	Dihydrofolate reductase	1.5.1.3	0.473
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.471
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.469
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.468
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.467
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.466
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.465
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
4kfj	FOL	Dihydrofolate reductase	1.5.1.3	0.463
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.462
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.461
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.461
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.461
3qly	55V	Uncharacterized protein	/	0.461
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.459
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
3eej	53R	Uncharacterized protein	/	0.457
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.457
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.456
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.456
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.455
3eek	53S	Uncharacterized protein	/	0.454
3eel	53T	Uncharacterized protein	/	0.454
3eem	53V	Uncharacterized protein	/	0.454
1dls	MTX	Dihydrofolate reductase	1.5.1.3	0.453
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.453
3sa1	6DR	Dihydrofolate reductase	/	0.453
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.453
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.452
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.451
2ph5	NAD	Homospermidine synthase	/	0.451
2zza	FOL	Dihydrofolate reductase	/	0.451
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.450
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.450
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.449
3qlx	QLR	Uncharacterized protein	/	0.448
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.447
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.446
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.445
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.445
3tqb	FOL	Dihydrofolate reductase	/	0.445
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.444
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.444
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.442
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.441
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.441