sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 1.000 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.544 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.528 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.525 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.519 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.517 | |
| 4qec | NAP | ElxO | / | 0.515 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.514 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.513 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.511 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.510 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.507 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.506 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.500 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.499 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.497 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.496 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.495 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.494 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.494 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.493 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.491 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.490 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.487 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.485 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.485 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.484 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.484 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.482 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.476 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.475 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.473 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.473 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.473 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.471 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.470 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.469 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.469 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.469 | |
| 3sju | NDP | Keto reductase | / | 0.468 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.467 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.467 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.466 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.465 | |
| 1sny | NAP | LD36273p | / | 0.463 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.462 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.460 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.460 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.459 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.457 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.456 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.456 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.456 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.455 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.455 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.453 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.453 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.452 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.448 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.448 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.448 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.447 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.447 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.446 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.446 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.445 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.445 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.445 | |
| 3uce | NDP | Dehydrogenase | / | 0.445 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.445 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.441 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.441 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.440 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 |