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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1guyNADMalate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1guyNADMalate dehydrogenase/1.000
1ur5NADMalate dehydrogenase/0.779
3gvhNADMalate dehydrogenase/0.627
1uxkNADMalate dehydrogenase/0.596
4i1iNADMalate dehydrogenase/0.579
2a94AP0L-lactate dehydrogenase1.1.1.270.568
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.565
2aa3AP0L-lactate dehydrogenase/0.552
1t2cNAIL-lactate dehydrogenase1.1.1.270.548
1uxjNADMalate dehydrogenase/0.548
2a92NAIL-lactate dehydrogenase/0.547
4uunNAIL-lactate dehydrogenase/0.543
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.542
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.539
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.531
1ez4NADL-lactate dehydrogenase1.1.1.270.521
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.521
4i9h1E4L-lactate dehydrogenase A chain1.1.1.270.521
1gv0NADMalate dehydrogenase/0.518
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.518
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.517
3d4pNADL-lactate dehydrogenase 11.1.1.270.513
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.509
2dc1NADProbable L-aspartate dehydrogenase/0.505
4ambDUDPutative glycosyl transferase/0.505
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.505
4k6fNAPPutative Acetoacetyl-CoA reductase/0.503
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.502
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.502
5a1tNAIL-lactate dehydrogenase/0.500
1xddAAYIntegrin alpha-L/0.498
1ie3NADMalate dehydrogenase/0.497
2ldbNADL-lactate dehydrogenase1.1.1.270.496
4nbwNADShort-chain dehydrogenase/reductase SDR/0.494
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.493
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.493
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.492
1mjbACOHistone acetyltransferase ESA1/0.491
3lqfNADGalactitol dehydrogenase/0.491
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.491
3tjzGNPADP-ribosylation factor 1/0.490
1xe55FEPlasmepsin-23.4.23.390.489
2y0mACOHistone acetyltransferase KAT8/0.489
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.489
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.488
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.487
1wzeNADMalate dehydrogenase/0.486
3wswNADL-lactate dehydrogenase/0.486
1b2lNDCAlcohol dehydrogenase1.1.1.10.485
4qecNAPElxO/0.485
5c77SAHProtein arginine N-methyltransferase SFM1/0.485
4m4922YL-lactate dehydrogenase A chain1.1.1.270.483
1mjaCOAHistone acetyltransferase ESA1/0.482
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.482
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.481
4dbzNDPPutative ketoacyl reductase1.3.10.481
1y7tNDPMalate dehydrogenase/0.480
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.480
1b8vNADMalate dehydrogenase/0.479
3e8xNAPBH1520 protein/0.479
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.479
1mj9COAHistone acetyltransferase ESA1/0.478
2vwqNAPGlucose 1-dehydrogenase/0.478
4yaoFMNNADPH--cytochrome P450 reductase/0.478
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.478
1emdNADMalate dehydrogenase/0.477
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.477
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.477
2ylzFADPhenylacetone monooxygenase1.14.13.920.477
3toxNAPPutative oxidoreductase/0.477
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.476
1fy7COAHistone acetyltransferase ESA1/0.475
3a3gDLZLumazine protein/0.475
3iocA5DPantothenate synthetase6.3.2.10.475
5jscFADPutative acyl-CoA dehydrogenase/0.475
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.474
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.474
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
1obnASVIsopenicillin N synthase1.21.3.10.473
2x7hPFNProstaglandin reductase 310.473
4blsAPCNTPase P4/0.473
1b8uNADMalate dehydrogenase/0.472
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.472
3b2sB2STrichothecene 3-O-acetyltransferase/0.472
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.472
3vvpBNUUncharacterized protein/0.472
4blrUTPNTPase P4/0.472
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.472
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.471
4g7gVFVLanosterol 14-alpha-demethylase/0.471
1bdmNAXMalate dehydrogenase/0.470
1ib6NADMalate dehydrogenase/0.470
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2i7pACOPantothenate kinase 32.7.1.330.470
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
1drhNAPDihydrofolate reductase1.5.1.30.469
2gv8NDPThiol-specific monooxygenase1.14.130.469
2rcyNAPPyrroline-5-carboxylate reductase/0.469
2vbdV10Isopenicillin N synthase1.21.3.10.469
3wagTYDGlycosyltransferase/0.469
1bmdNADMalate dehydrogenase/0.468
1w6hTITPlasmepsin-23.4.23.390.468
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
2rqfJH3Hemolymph juvenile hormone binding protein/0.468
2x0iNAIMalate dehydrogenase/0.468
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.468
3pm1ETHTH-type transcriptional regulator QacR/0.468
4dfg0JVGag-Pol polyprotein3.4.23.160.468
5jlaNADPutative short-chain dehydrogenase/reductase/0.468
2c29NAPDihydroflavonol 4-reductase/0.467
2he5NDPAldo-keto reductase family 1 member C211.1.10.467
3r9uFADThioredoxin reductase/0.467
4du82P0Mevalonate diphosphate decarboxylase/0.467
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.467
4g3jVNTLanosterol 14-alpha-demethylase/0.467
4ipw1G7Mycocyclosin synthase1.14.21.90.467
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.466
1pjcNADAlanine dehydrogenase/0.466
1vbiNADMalate/L-lactate dehydrogenase family protein/0.466
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.466
1yqxNAPSinapyl alcohol dehydrogenase/0.466
2g1n1IGRenin3.4.23.150.466
2oapANPType II secretion system protein (GspE-2)/0.466
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.466
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.466
3br3ETHTH-type transcriptional regulator QacR/0.466
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.466
4a862ANMajor pollen allergen Bet v 1-A/0.466
4rosAPRMalate dehydrogenase/0.466
1tehNADAlcohol dehydrogenase class-31.1.1.10.465
3ai3NDPNADPH-sorbose reductase/0.465
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.465
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.465
4a83DXCMajor pollen allergen Bet v 1-A/0.465
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.465
4q71FADBifunctional protein PutA/0.465
4xiwAZMCarbonic anhydrase, alpha type/0.465
1xe65FPPlasmepsin-23.4.23.390.464
2ahrNAPPyrroline-5-carboxylate reductase/0.464
2ikuLIYRenin3.4.23.150.464
2y4gTIRTamL/0.464
1udbUFGUDP-glucose 4-epimerase5.1.3.20.463
2ft9CHDFatty acid-binding protein 2, liver/0.463
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.463
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.463
2ien017Gag-Pol polyprotein3.4.23.160.463
2ob0ACON-alpha-acetyltransferase 50/0.463
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.463
3b6zCO7Enoyl reductase LovC10.463
3gw9VNILanosterol 14-alpha-demethylase/0.463
3h3jNADL-lactate dehydrogenase 11.1.1.270.463
3qlsNDPDihydrofolate reductase1.5.1.30.463
4ejmNAPPutative zinc-binding dehydrogenase/0.463
1wziNDPMalate dehydrogenase/0.462
2p83MR0Beta-secretase 13.4.23.460.462
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
3kb1ADPIron-sulfur cluster carrier protein/0.462
3ohh3HHBeta-secretase 13.4.23.460.462
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.462
4rvfTYDD-mycarose 3-C-methyltransferase/0.462
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.462
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.462
2omeNADC-terminal-binding protein 2/0.461
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.461
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.461
4yvz3ATDNA integrity scanning protein DisA/0.461
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
2cy0NAPShikimate dehydrogenase (NADP(+))/0.460
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.460
2g1y5IGRenin3.4.23.150.460
2ozuACOHistone acetyltransferase KAT6A/0.460
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.460
3ieuGDPGTPase Era/0.460
4b79NADProbable short-chain dehydrogenase/0.460
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.460
4m83ERYOleandomycin glycosyltransferase2.4.10.460
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1fm4DXCMajor pollen allergen Bet v 1-L/0.459
1ma0NADAlcohol dehydrogenase class-31.1.1.10.459
2dftADPShikimate kinase2.7.1.710.459
2il2LIXRenin3.4.23.150.459
2rlcCHDCholoylglycine hydrolase3.5.1.240.459
3lzs017Gag-Pol polyprotein3.4.23.160.459
3zoiM2WIsopenicillin N synthase1.21.3.10.459
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.459
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.459
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.458
1u4oNDDL-lactate dehydrogenase1.1.1.270.458
3dr8ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase/0.458
3hl0NADMaleylacetate reductase/0.458
3s1dZIRCytokinin dehydrogenase 11.5.99.120.458
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.458
4ji91M3Tyrosine-protein kinase JAK2/0.458
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.458
4wecNADShort chain dehydrogenase/0.458
1me6IVSPlasmepsin-23.4.23.390.457
1qorNDPQuinone oxidoreductase 1/0.457
2d29FADAcyl-CoA dehydrogenase/0.457
2iviACWIsopenicillin N synthase1.21.3.10.457
3vthAP2Carbamoyltransferase/0.457
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.457
4gl4NAIAlcohol dehydrogenase class-3/0.457
4q73FADBifunctional protein PutA/0.457
4xguADPPutative pachytene checkpoint protein 2/0.457
1hbvGANGag-Pol polyprotein/0.456
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.456
2g1s4IGRenin3.4.23.150.456
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.456
3eldSFGMethyltransferase/0.456
3kp4MIITranscriptional regulator TcaR/0.456
3uylTYDProbable NDP-rhamnosyltransferase/0.456
4a84DXCMajor pollen allergen Bet v 1-A/0.456
2g8yNADHydroxycarboxylate dehydrogenase B/0.455
2q4wFADCytokinin dehydrogenase 71.5.99.120.455
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3zkyWT4Isopenicillin N synthase1.21.3.10.455
4eueNAITrans-2-enoyl-CoA reductase [NADH]/0.455
4lcjNADC-terminal-binding protein 2/0.455
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.455
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.455
1h73ANPHomoserine kinase2.7.1.390.454
1qiqACCIsopenicillin N synthase1.21.3.10.454
2givACOHistone acetyltransferase KAT8/0.454
2gjlFMNNitronate monooxygenase1.13.12.160.454
2iyfERYOleandomycin glycosyltransferase2.4.10.454
2ou2ACOHistone acetyltransferase KAT5/0.454
3ai2NDPNADPH-sorbose reductase/0.454
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.454
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.454
4dc0NDPPutative ketoacyl reductase1.3.10.454
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
1bdlIM1Gag-Pol polyprotein3.4.23.160.453
1bim0QBRenin3.4.23.150.453
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1x27ASP_TYR_VAL_HIS_PTRTyrosine-protein kinase Lck2.7.10.20.453
2o4cNADErythronate-4-phosphate dehydrogenase/0.453
2qirCOAAminoglycoside 6-N-acetyltransferase type Ib11/0.453
2xgs44PUncharacterized protein/0.453
2xviFADPutative flavin-containing monooxygenase/0.453
3i0pNADMalate dehydrogenase, putative/0.453
3lpkZ76Beta-secretase 13.4.23.460.453
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.453
4ejvLCLTranscriptional regulator TcaR/0.453
4phlPILPhosphodiesterase/0.453
1cdoNADAlcohol dehydrogenase 11.1.1.10.452
1hb3SCVIsopenicillin N synthase1.21.3.10.452
1jioDEB6-deoxyerythronolide B hydroxylase/0.452
1uxyEPUUDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.452
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.452
2g1r3IGRenin3.4.23.150.452
2ifaFMNUncharacterized protein/0.452
3in6FMNUncharacterized protein/0.452
3qt62P0Mevalonate diphosphate decarboxylase/0.452
3vdqNAD3-hydroxybutyrate dehydrogenase/0.452
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.452
4eb5PLPCysteine desulfurase IscS 2/0.452
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.452
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.452
1bk0ACVIsopenicillin N synthase1.21.3.10.451
2ge3ACOProbable acetyltransferase/0.451
2hldANPATP synthase subunit alpha, mitochondrial/0.451
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.451
2i4qUA4Renin3.4.23.150.451
2y60M8FIsopenicillin N synthase1.21.3.10.451
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.451
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.451
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.451
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.451
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.451
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.451
1hb1OCVIsopenicillin N synthase1.21.3.10.450
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.450
2ebaFADPutative glutaryl-CoA dehydrogenase/0.450
2jb4A14Isopenicillin N synthase1.21.3.10.450
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.450
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.450
3nbvANPKetohexokinase/0.450
3oibFDAPutative acyl-CoA dehydrogenase/0.450
3qfrFMNNADPH--cytochrome P450 reductase/0.450
3rpeFADPutative modulator of drug activity/0.450
4a81DXCMajor pollen allergen Bet v 1-A/0.450
4eb7PLPCysteine desulfurase IscS 2/0.450
4ktkKTKCytochrome P450/0.450
4l4xNDPAmphI/0.450
1kp3ATPArgininosuccinate synthase6.3.4.50.449
1q0qNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.449
2bu9HFVIsopenicillin N synthase1.21.3.10.449
2d8aNADL-threonine 3-dehydrogenase/0.449
2igoFADPyranose 2-oxidase/0.449
2x0rNADMalate dehydrogenase/0.449
2xtnGTPGTPase IMAP family member 2/0.449
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.449
3jv7NADSecondary alcohol dehydrogenase/0.449
3jzdNADMaleylacetate reductase/0.449
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.449
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.449
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
4i8zG08Gag-Pol polyprotein3.4.23.160.449
4tvbNADHomospermidine synthase2.5.1.440.449
5cdtNAJAlcohol dehydrogenase E chain1.1.1.10.449
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.448
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
1vrwNAIEnoyl-ACP reductase/0.448
1yqdNAPSinapyl alcohol dehydrogenase/0.448
2c27ACOMycothiol acetyltransferase2.3.1.1890.448
2lfoGCHFatty acid-binding protein, liver/0.448
3b70NAPEnoyl reductase LovC10.448
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
3h86AP5Adenylate kinase/0.448
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4bfzZVZPantothenate kinase2.7.1.330.448
4loi1YCStimulator of interferon genes protein/0.448
4lx9ACON-alpha-acetyltransferase2.3.10.448
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.448
4oztP1AEcdysone receptor, putative/0.448
4xrgNADHomospermidine synthase2.5.1.440.448
5ahsFADAcyl-CoA dehydrogenase/0.448
4zj8SUVOrexin receptor type 1/0.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1kkq471Peroxisome proliferator-activated receptor alpha/0.447
1l2sSTCBeta-lactamase3.5.2.60.447
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1szgFNSCytochrome b2, mitochondrial1.1.2.30.447
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.447
2c20NADUDP-glucose 4-epimerase/0.447
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.447
2ejvNADL-threonine 3-dehydrogenase/0.447
2g1o2IGRenin3.4.23.150.447
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.447
2hu2NADC-terminal binding protein 1/0.447
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.447
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.447
3a4vNADNDP-sugar epimerase/0.447
3c1y2BADNA integrity scanning protein DisA/0.447
3gfbNADL-threonine 3-dehydrogenase/0.447
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.447
5c41ACPRibokinase/0.447
5cfpC2EStimulator of interferon genes protein/0.447
1dgmADNAdenosine kinase2.7.1.200.446
1g1aNADdTDP-glucose 4,6-dehydratase/0.446
1hkuNADC-terminal-binding protein 11.1.10.446
1obbNADAlpha-glucosidase3.2.1.200.446
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.446
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.446
1u3dFADCryptochrome-1/0.446
1yb5NAPQuinone oxidoreductase1.6.5.50.446
2bjfDXCCholoylglycine hydrolase3.5.1.240.446
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.446
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.446
2i7nACOPantothenate kinase 12.7.1.330.446
2npxNADNADH peroxidase1.11.1.10.446
2vhtATPNTPase P4/0.446
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3gqvNAPEnoyl reductase LovC10.446
3ig6438Urokinase-type plasminogen activator3.4.21.730.446
3pwm017Gag-Pol polyprotein3.4.23.160.446
3qwbNDPProbable quinone oxidoreductase1.6.5.50.446
3rk1ATPN-type ATP pyrophosphatase superfamily/0.446
3w32W32Epidermal growth factor receptor2.7.10.10.446
3w8wFADPutative FAD-dependent oxygenase EncM/0.446
4a6rTA8Probable aminotransferase/0.446
4enhFVXCholesterol 24-hydroxylase/0.446
4esoNAPPutative oxidoreductase/0.446
4irnFADAnaB/0.446
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.446
1ai9NDPDihydrofolate reductase1.5.1.30.445
1p0hACOMycothiol acetyltransferase2.3.1.1890.445
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
2bi8FADUDP-galactopyranose mutase5.4.99.90.445
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
3bc3OPTCathepsin L13.4.22.150.445
3c212BADNA integrity scanning protein DisA/0.445
3ibqATPPyridoxal kinase/0.445
3lpiZ74Beta-secretase 13.4.23.460.445
3w8eNAD3-hydroxybutyrate dehydrogenase/0.445
4hj6FMNLOV protein/0.445
4hwkNAPSepiapterin reductase1.1.1.1530.445
4opiFDAConserved Archaeal protein/0.445
4rvgTYDD-mycarose 3-C-methyltransferase/0.445
4udrFAD5-(hydroxymethyl)furfural oxidase/0.445
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.445
5fm7ADPRuvB-like helicase/0.445
1hf3NADAlcohol dehydrogenase E chain1.1.1.10.444
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
1nzdUPGDNA beta-glucosyltransferase/0.444
1o6zNADMalate dehydrogenase/0.444
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.444
1qjfACSIsopenicillin N synthase1.21.3.10.444
1rq1FADEndoplasmic oxidoreductin-11.8.40.444
1vikBAYGag-Pol polyprotein/0.444
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
2hfuMEVMevalonate kinase/0.444
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
2nq8ZIDEnoyl-ACP reductase/0.444
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.444
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.444
2v16C47Renin3.4.23.150.444
3bg7FADPyranose 2-oxidase/0.444
3f03FMNPentaerythritol tetranitrate reductase/0.444
3m6iNADL-arabinitol 4-dehydrogenase1.1.1.120.444
3own3OXRenin3.4.23.150.444
3phiNDPShikimate dehydrogenase (NADP(+))/0.444
3tog079Gag-Pol polyprotein2.7.7.490.444
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.444
4cdmFO1Deoxyribodipyrimidine photolyase/0.444
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.444
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.444
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.444
4o1mNADEnoyl-acyl carrier reductase/0.444
4o3mADPBloom syndrome protein3.6.4.120.444
4q0kGA3Phytohormone-binding protein/0.444
1ae1NAPTropinone reductase 1/0.443
1bwsNDPGDP-L-fucose synthase/0.443
1civNAPMalate dehydrogenase [NADP], chloroplastic1.1.1.820.443
1gqtACPRibokinase/0.443
1oc1ASVIsopenicillin N synthase1.21.3.10.443
1tqf32PBeta-secretase 13.4.23.460.443
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.443
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.443
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.443
3bgxTMPThymidylate synthase/0.443
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.443
3gwfNAPCyclohexanone monooxygenase/0.443
3k5dXLIBeta-secretase 13.4.23.460.443
3kpbSAMUncharacterized protein MJ0100/0.443
3mx5UTPNucleoprotein/0.443
3p8jFMNPentaerythritol tetranitrate reductase/0.443
3pqfNADL-lactate dehydrogenase1.1.1.270.443
3sglFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.443
4bfvZVVPantothenate kinase2.7.1.330.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4dh60KNBeta-secretase 13.4.23.460.443
4gh5NADShort-chain dehydrogenase/reductase SDR/0.443
4iv6FDAIsovaleryl-CoA dehydrogenase/0.443
4jtqNAPAldo-keto reductase family 1 member C2/0.443
4mihFADPyranose 2-oxidase1.1.3.100.443
4p63NADProbable deoxyhypusine synthase2.5.1.460.443
5dp2NAPCurF/0.443
5hwsNAP2-dehydropantoate 2-reductase/0.443
1b15NAEAlcohol dehydrogenase1.1.1.10.442
1ia1NDPDihydrofolate reductase1.5.1.30.442
1kvkATPMevalonate kinase2.7.1.360.442
1qy5NECEndoplasmin/0.442
2fj1CTCTetracycline repressor protein class D/0.442
2g20L1ARenin3.4.23.150.442
2ql6ADPNicotinamide riboside kinase 1/0.442
2w3bNDPDihydrofolate reductase1.5.1.30.442
2y3rTRKTamL/0.442
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.442
3gegNADShort-chain dehydrogenase/reductase SDR/0.442
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.442
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.442
3ut5LOCTubulin beta chain/0.442
4eo3FMNBacterioferritin comigratory protein/NADH dehydrogenase/0.442
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.442
4jwpACOGCN5-related N-acetyltransferase/0.442
4pzrCOAHistone acetyltransferase p300/0.442
4qxp1YEStimulator of interferon genes protein/0.442
5f8eSAHPossible transcriptional regulatory protein/0.442
1ipeNDPTropinone reductase 21.1.1.2360.441
1jkx138Phosphoribosylglycinamide formyltransferase/0.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1kp2ATPArgininosuccinate synthase6.3.4.50.441
1nvtNAPShikimate dehydrogenase (NADP(+))/0.441
2cvqNDPMalate dehydrogenase/0.441
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.441
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.441
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.441
2vjmCOAFormyl-CoA:oxalate CoA-transferase/0.441
2wo7ASVIsopenicillin N synthase1.21.3.10.441
3cisATPUniversal stress protein Rv2623/0.441
3em3478Gag-Pol polyprotein3.4.23.160.441
3ensENSCoagulation factor X3.4.21.60.441
3f63GTXGlutathione transferase GST1-4/0.441
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.441
3to6LYS_CMCHistone acetyltransferase ESA1/0.441
4fryNADPutative signal-transduction protein with CBS domains/0.441
4gavFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.441
4iae1DXAlr2278 protein/0.441
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.441
5idwNAPShort-chain dehydrogenase/reductase SDR/0.441
5kwvANPPantothenate synthetase/0.441
1f8fNADBenzyl alcohol dehydrogenase/0.440
1hdoNAPFlavin reductase (NADPH)/0.440
1nzfUPGDNA beta-glucosyltransferase/0.440
1qrpHH0Pepsin A-43.4.23.10.440
1t2dNADL-lactate dehydrogenase1.1.1.270.440
1x1aSAMC-20 methyltransferase/0.440
1xl5190Gag-Pol polyprotein3.4.23.160.440
2briANPUridylate kinase2.7.4.220.440
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.440
2yk2YJXHeat shock protein HSP 90-alpha/0.440
3h06VBPGlutamate receptor 2/0.440
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3nxxNDPDihydrofolate reductase1.5.1.30.440
3p62FMNPentaerythritol tetranitrate reductase/0.440
3q43D66M1 family aminopeptidase3.4.110.440
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.440
4a87NARMajor pollen allergen Bet v 1-A/0.440
4an4DUDPutative glycosyl transferase/0.440
4dpy2P0Mevalonate diphosphate decarboxylase/0.440
4eu5COASuccinyl-CoA:acetate CoA-transferase/0.440
4plpNADHomospermidine synthase2.5.1.440.440
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.440