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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.21.000
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.474
3vqsJT1Genome polyprotein/0.472
2z1mNDPGDP-mannose 4,6-dehydratase/0.471
3fpzAHZThiamine thiazole synthase/0.470
3f8rNAPNADH oxidase/thioredoxin reductase/0.467
2wsbNADGalactitol dehydrogenase/0.465
3jskAHZThiamine thiazole synthase/0.464
3s5wFADL-ornithine N(5)-monooxygenase/0.464
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.464
5a3bAPRSIR2 family protein/0.464
3b70NAPEnoyl reductase LovC10.460
2yr5FADPhenylalanine 2-monooxygenase precursor1.13.12.90.458
3cgdFADCoenzyme A disulfide reductase/0.456
3cgeFADCoenzyme A disulfide reductase/0.456
3tm5SFGUncharacterized protein/0.455
2b9wFADPutative aminooxidase/0.454
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.454
1w4xFADPhenylacetone monooxygenase1.14.13.920.453
3axbFADPutative oxidoreductase/0.453
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.453
4fn4NADShort chain dehydrogenase/0.453
1gheACOAcetyltransferase2.3.10.452
2ylzFADPhenylacetone monooxygenase1.14.13.920.451
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.451
3nxxNDPDihydrofolate reductase1.5.1.30.451
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3slkNDPPolyketide synthase extender module 2/0.448
2he5NDPAldo-keto reductase family 1 member C211.1.10.445
2o7oDXTTetracycline repressor protein class D/0.445
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.445
3hv5R24Mitogen-activated protein kinase 14/0.445
4b7xNAPProbable oxidoreductase/0.445
1qo8FADFumarate reductase flavoprotein subunit/0.444
2ylxFADPhenylacetone monooxygenase1.14.13.920.444
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.444
2ejvNADL-threonine 3-dehydrogenase/0.443
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4c04SFGProtein arginine N-methyltransferase 6/0.443
1rp0AHZThiamine thiazole synthase, chloroplastic/0.442
1u3dFADCryptochrome-1/0.442
3kybFADUDP-galactopyranose mutase5.4.99.90.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3f8pNADNADH oxidase/thioredoxin reductase/0.441
3tz3B36Acetyl-CoA carboxylase/0.441
4q73FADBifunctional protein PutA/0.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
3gqvNAPEnoyl reductase LovC10.440
3h0sB38Acetyl-CoA carboxylase/0.440
3pdqKC6Lysine-specific demethylase 4A1.14.110.440
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440