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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gsnFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gsnFADGlutathione reductase, mitochondrial1.8.1.71.000
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.771
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.646
1grgFADGlutathione reductase, mitochondrial1.8.1.70.637
1grhFADGlutathione reductase, mitochondrial1.8.1.70.636
1greFADGlutathione reductase, mitochondrial1.8.1.70.633
3grsFADGlutathione reductase, mitochondrial1.8.1.70.632
1graFADGlutathione reductase, mitochondrial1.8.1.70.630
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.613
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.597
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.595
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.593
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.556
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.555
1grbFADGlutathione reductase, mitochondrial1.8.1.70.550
2v6oFADThioredoxin glutathione reductase/0.512
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.508
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.504
2r9zFADGlutathione amide reductase/0.478
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.470
1gerFADGlutathione reductase1.8.1.70.469
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.469
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.467
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.467
3djgFADGlutathione reductase, mitochondrial1.8.1.70.464
2rabFADGlutathione amide reductase/0.459