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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1greFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1greFADGlutathione reductase, mitochondrial1.8.1.71.000
1grgFADGlutathione reductase, mitochondrial1.8.1.70.903
1grhFADGlutathione reductase, mitochondrial1.8.1.70.898
1graFADGlutathione reductase, mitochondrial1.8.1.70.846
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.838
3grsFADGlutathione reductase, mitochondrial1.8.1.70.819
1grbFADGlutathione reductase, mitochondrial1.8.1.70.724
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.637
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.618
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.611
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.603
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.602
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.594
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.554
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.553
2v6oFADThioredoxin glutathione reductase/0.527
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.522
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.482
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
2r9zFADGlutathione amide reductase/0.472
3djgFADGlutathione reductase, mitochondrial1.8.1.70.471
2rabFADGlutathione amide reductase/0.465
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.463
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.458
1gerFADGlutathione reductase1.8.1.70.454
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.448
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.448