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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gr1FADFerredoxin--NADP reductase1.18.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gr1FADFerredoxin--NADP reductase1.18.1.21.000
1e62FADFerredoxin--NADP reductase1.18.1.20.726
1h42FADFerredoxin--NADP reductase1.18.1.20.718
1ogiFADFerredoxin--NADP reductase1.18.1.20.708
3zbtFADFerredoxin--NADP reductase1.18.1.20.689
1queFADFerredoxin--NADP reductase1.18.1.20.657
1ogjFADFerredoxin--NADP reductase1.18.1.20.647
1w35FADFerredoxin--NADP reductase1.18.1.20.645
1e63FADFerredoxin--NADP reductase1.18.1.20.628
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.628
1e64FADFerredoxin--NADP reductase1.18.1.20.621
1h85FADFerredoxin--NADP reductase1.18.1.20.613
1qgzFADFerredoxin--NADP reductase1.18.1.20.611
1qh0FADFerredoxin--NADP reductase1.18.1.20.609
1bjkFADFerredoxin--NADP reductase1.18.1.20.604
4c43FADFerredoxin--NADP reductase1.18.1.20.604
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.597
1qgyFADFerredoxin--NADP reductase1.18.1.20.595
3zc3FADFerredoxin--NADP reductase1.18.1.20.593
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.591
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.588
2b5oFADFerredoxin--NADP reductase1.18.1.20.587
3vo2FADFerredoxin--NADP reductase/0.585
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.585
1go2FADFerredoxin--NADP reductase1.18.1.20.571
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.566
1gjrFADFerredoxin--NADP reductase1.18.1.20.564
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.555
4bprFADFerredoxin--NADP reductase1.18.1.20.555
1b2rFADFerredoxin--NADP reductase1.18.1.20.554
1sm4FADFerredoxin--NADP reductase/0.551
2rc6FADFerredoxin--NADP reductase/0.551
3jqrFADFerredoxin--NADP reductase, apicoplast/0.548
1gaqFADFerredoxin/0.544
1ewyFADFerredoxin--NADP reductase1.18.1.20.543
1gawFADFerredoxin/0.543
3w5uFADFerredoxin/0.543
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.540
3qfcFADNADPH--cytochrome P450 reductase/0.522
1w87FADFerredoxin--NADP reductase1.18.1.20.521
3qftFADNADPH--cytochrome P450 reductase/0.516
2ok8FADFerredoxin--NADP reductase, apicoplast/0.509
3fpkFADFerredoxin-NADP reductase/0.503
3qfsFADNADPH--cytochrome P450 reductase/0.503
2piaFMNPhthalate dioxygenase reductase/0.502
2bpoFADNADPH--cytochrome P450 reductase/0.494
2vnjFADNADPH:ferredoxin reductase/0.491
5ah5LSSLeucine--tRNA ligase/0.491
1ex75GPGuanylate kinase2.7.4.80.486
3qe2FADNADPH--cytochrome P450 reductase/0.485
3rsv3RSBeta-secretase 13.4.23.460.485
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.485
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.483
4yaoFADNADPH--cytochrome P450 reductase/0.482
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.481
1ja1FADNADPH--cytochrome P450 reductase/0.478
4y9uFADNADPH--cytochrome P450 reductase/0.477
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.473
1obnASVIsopenicillin N synthase1.21.3.10.472
4bfuZVUPantothenate kinase2.7.1.330.472
4h1q0XXMatrix metalloproteinase-93.4.24.350.471
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.470
1amoFADNADPH--cytochrome P450 reductase/0.469
2bf4FADNADPH--cytochrome P450 reductase/0.468
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.468
1yw8A75Methionine aminopeptidase 2/0.467
3wleNAD(R)-specific carbonyl reductase/0.466
4bfxZVXPantothenate kinase2.7.1.330.466
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.466
4j7hTRHPCZA361.3/0.466
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.466
4y7cFADNADPH--cytochrome P450 reductase/0.466
4yauFADNADPH--cytochrome P450 reductase/0.466
1r5hAO2Methionine aminopeptidase 2/0.465
2ea2F77Methionine aminopeptidase 2/0.464
4dyn0MRNucleoprotein/0.463
4yafFADNADPH--cytochrome P450 reductase/0.463
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
2wzySQXSoluble acetylcholine receptor/0.461
2zevIPEGeranylgeranyl pyrophosphate synthase/0.461
5a4vQUEGlutathione S-transferase F22.5.1.180.461
1jumBERHTH-type transcriptional regulator QacR/0.459
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.459
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3rtnRTNBeta-secretase 13.4.23.460.459
1c7oPPGHemolysin/0.458
2ejkSAHDiphthine synthase/0.458
2x06NADL-sulfolactate dehydrogenase/0.458
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.457
5a4wQCTGlutathione S-transferase F22.5.1.180.457
4u140HKMuscarinic acetylcholine receptor M3/0.457
2bf4FMNNADPH--cytochrome P450 reductase/0.456
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.456
2vyqFADFerredoxin--NADP reductase1.18.1.20.456
4y9rFADNADPH--cytochrome P450 reductase/0.456
2ejzSAHDiphthine synthase/0.455
4ba5PXGProbable aminotransferase/0.455
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.454
1gky5GPGuanylate kinase2.7.4.80.453
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.453
2p6dSAHDiphthine synthase/0.453
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.452
4b66FADL-ornithine N(5)-monooxygenase/0.452
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.451
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
2wjoQUDBeta-secretase 13.4.23.460.451
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
4q0kGA3Phytohormone-binding protein/0.451
1a8pFADFerredoxin--NADP reductase/0.450
1r58AO5Methionine aminopeptidase 2/0.450
1vbiNADMalate/L-lactate dehydrogenase family protein/0.450
1xddAAYIntegrin alpha-L/0.450
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2gv8NDPThiol-specific monooxygenase1.14.130.450
2gyuHI6Acetylcholinesterase3.1.1.70.450
2vn1FK5Peptidylprolyl isomerase/0.450
3p0fBAUUridine phosphorylase 22.4.2.30.450
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.450
1j9zFADNADPH--cytochrome P450 reductase/0.449
2dsgSAHDiphthine synthase/0.448
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
2rc5FADFerredoxin--NADP reductase/0.448
3e6eDCSAlanine racemase/0.448
3kp4MIITranscriptional regulator TcaR/0.448
4j3mAJ8Tankyrase-22.4.2.300.448
4to4DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.448
1s4oGDPGlycolipid 2-alpha-mannosyltransferase/0.447
1tllFMNNitric oxide synthase, brain1.14.13.390.447
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.447
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.447
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.447
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.447
1e79ATPATP synthase subunit alpha, mitochondrial/0.446
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.446
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.446
1qzyTDEMethionine aminopeptidase 2/0.446
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.446
4bfwZVWPantothenate kinase2.7.1.330.446
4fk8FADFerredoxin--NADP reductase/0.446
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.445
1ja1FMNNADPH--cytochrome P450 reductase/0.445
1x1cSAHC-20 methyltransferase/0.445
2jb4A14Isopenicillin N synthase1.21.3.10.445
3ojxFADNADPH--cytochrome P450 reductase/0.445
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.445
4bfvZVVPantothenate kinase2.7.1.330.445
4z87GDPInosine-5'-monophosphate dehydrogenase/0.445
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.444
2flhZEACytokinin-specific binding protein/0.444
3h3t16HCollagen type IV alpha-3-binding protein/0.444
3n0bFADFlavin-dependent thymidylate synthase2.1.1.1480.444
4bftZVTPantothenate kinase2.7.1.330.444
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.443
3kboNDPGlyoxylate/hydroxypyruvate reductase A/0.443
3nt5NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.443
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4y0kNAPAntE/0.443
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1qiqACCIsopenicillin N synthase1.21.3.10.442
2iviACWIsopenicillin N synthase1.21.3.10.442
3af1GDPPantothenate kinase2.7.1.330.442
4x9dU5PUncharacterized protein MJ1435/0.442
1amoFMNNADPH--cytochrome P450 reductase/0.441
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2bn4FMNNADPH--cytochrome P450 reductase/0.441
2dekSAHDiphthine synthase/0.441
2dv7SAHDiphthine synthase/0.441
2ed3SAHDiphthine synthase/0.441
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.441
2gmuPDGPutative pyridoxamine 5-phosphate-dependent dehydrase/0.441
3iktNADRedox-sensing transcriptional repressor Rex/0.441
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3wqmB29Diterpene synthase3.1.7.80.441
4j7gTRHPCZA361.3/0.441
4jtqNAPAldo-keto reductase family 1 member C2/0.441
4xguADPPutative pachytene checkpoint protein 2/0.441
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1tllFADNitric oxide synthase, brain1.14.13.390.440
1u2rSO1Elongation factor 2/0.440
2g1r3IGRenin3.4.23.150.440
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.440
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4qnuGEKtRNA U34 carboxymethyltransferase/0.440
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.440