Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.304

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3041.000
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.575
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.574
2wsbNADGalactitol dehydrogenase/0.567
3w8dNAD3-hydroxybutyrate dehydrogenase/0.559
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.558
3ak4NADNADH-dependent quinuclidinone reductase/0.557
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.556
2wdzNADGalactitol dehydrogenase/0.554
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.551
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.550
3w8fNAD3-hydroxybutyrate dehydrogenase/0.549
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.547
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.544
4gh5NADShort-chain dehydrogenase/reductase SDR/0.544
5jlaNADPutative short-chain dehydrogenase/reductase/0.544
1iy8NADLevodione reductase/0.543
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.541
1pr9NAPL-xylulose reductase1.1.1.100.541
3qrwNDPPutative ketoacyl reductase1.3.10.541
1zemNADXylitol dehydrogenase/0.537
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.536
5lc1NADL-threonine 3-dehydrogenase/0.535
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.531
4yaiNAIC alpha-dehydrogenase/0.531
1wntNAPL-xylulose reductase1.1.1.100.529
3rj9NADAlcohol dehydrogenase1.1.1.10.529
3wdsNADNADH-dependent quinuclidinone reductase/0.527
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.527
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.525
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.525
1b15NAEAlcohol dehydrogenase1.1.1.10.524
4yagNAIC alpha-dehydrogenase/0.523
3w8eNAD3-hydroxybutyrate dehydrogenase/0.522
1b16NAQAlcohol dehydrogenase1.1.1.10.521
3rj5NADAlcohol dehydrogenase1.1.1.10.521
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.520
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.519
2yy7NADL-threonine dehydrogenase/0.516
3vdqNAD3-hydroxybutyrate dehydrogenase/0.516
4j7xNAPSepiapterin reductase1.1.1.1530.516
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.515
4dc1NDPPutative ketoacyl reductase1.3.10.514
4fn4NADShort chain dehydrogenase/0.513
1x7gNAPPutative ketoacyl reductase1.3.10.510
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.510
4b79NADProbable short-chain dehydrogenase/0.509
1n5dNDPCarbonyl reductase [NADPH] 1/0.507
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.507
2dteNAIGlucose 1-dehydrogenase related protein/0.507
4nbwNADShort-chain dehydrogenase/reductase SDR/0.507
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.506
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.506
1mg5NAIAlcohol dehydrogenase1.1.1.10.505
3a4vNADNDP-sugar epimerase/0.504
3sjuNDPKeto reductase/0.504
3uxyNADShort-chain dehydrogenase/reductase SDR/0.504
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.503
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.502
1geeNADGlucose 1-dehydrogenase1.1.1.470.501
4j7uNAPSepiapterin reductase1.1.1.1530.501
1w4zNAPPutative ketoacyl reductase1.3.10.500
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.500
1gcoNADGlucose 1-dehydrogenase1.1.1.470.499
2p5uNADUDP-glucose 4-epimerase/0.498
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.498
3a1nNADNDP-sugar epimerase/0.497
1sbyNADAlcohol dehydrogenase1.1.1.10.495
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.494
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.494
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.493
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.493
3s55NADPutative short-chain dehydrogenase/reductase/0.491
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.491
3d3wNAPL-xylulose reductase1.1.1.100.489
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.489
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.488
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.488
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.487
3lqfNADGalactitol dehydrogenase/0.487
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.486
3gy0NAPNAD(P)-dependent oxidoreductase/0.485
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.484
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.484
4hwkNAPSepiapterin reductase1.1.1.1530.484
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.483
1x7hNDPPutative ketoacyl reductase1.3.10.483
3sx2NADUncharacterized protein/0.483
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.483
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.482
3toxNAPPutative oxidoreductase/0.481
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.481
3p19NDPPutative blue fluorescent protein/0.479
1ae1NAPTropinone reductase 1/0.478
1b14NADAlcohol dehydrogenase1.1.1.10.477
2bd0NAPSepiapterin reductase/0.477
5jy1NADPutative short-chain dehydrogenase/reductase/0.477
1rwbNADGlucose 1-dehydrogenase1.1.1.470.475
1xg5NAPDehydrogenase/reductase SDR family member 11/0.475
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.473
5idwNAPShort-chain dehydrogenase/reductase SDR/0.473
1ipeNDPTropinone reductase 21.1.1.2360.471
1oaaNAPSepiapterin reductase1.1.1.1530.471
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.471
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.470
2yutNAPPutative short-chain oxidoreductase/0.470
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.470
1g6kNADGlucose 1-dehydrogenase1.1.1.470.469
3ajrNADNDP-sugar epimerase/0.469
4bmvNAPShort-chain dehydrogenase/0.469
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.469
1xkqNDPUncharacterized protein/0.468
3f1kNAPUncharacterized oxidoreductase YciK10.467
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
5ig2NADShort-chain dehydrogenase/reductase SDR/0.467
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.466
1snyNAPLD36273p/0.464
2jahNDPClavaldehyde dehydrogenase/0.464
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.464
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.463
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.463
5jydNADShort chain dehydrogenase/0.462
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.459
3wmxNADNAD dependent epimerase/dehydratase/0.459
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.458
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.458
3r3sNADPutative oxidoreductase/0.456
3ai2NDPNADPH-sorbose reductase/0.455
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.454
3uceNDPDehydrogenase/0.454
1z7eATPBifunctional polymyxin resistance protein ArnA/0.452
4b8zNAPGDP-L-fucose synthase1.1.1.2710.452
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3tscNADUncharacterized protein/0.450
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.445
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1kvrNADUDP-glucose 4-epimerase5.1.3.20.443
4esoNAPPutative oxidoreductase/0.443
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.442
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4qecNAPElxO/0.441
3ggoNAIPrephenate dehydrogenase/0.440
3l77NJPShort-chain alcohol dehydrogenase/0.440