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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1g28FMNPHY3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1g28FMNPHY3/1.000
2v1aFMNNPH1-1/0.554
5djtFMNNPH1-2/0.531
5efwFMNNPH1-1/0.530
4eepFMNPhototropin-22.7.11.10.524
4hhdFMNPhototropin-12.7.11.10.511
2v0uFMNNPH1-1/0.498
2z6dFMNPhototropin-22.7.11.10.488
3ue6FMNAureochrome1/0.485
4eetFMNPhototropin-22.7.11.10.485
5djuFMNNPH1-2/0.482
2pd8FADVivid PAS protein VVD/0.480
4hiaFMNLOV protein/0.480
4hj6FMNLOV protein/0.480
1zeoC01Peroxisome proliferator-activated receptor gamma/0.479
4eerFMNPhototropin-22.7.11.10.479
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.477
3p7nFMNLight-activated DNA-binding protein EL222/0.477
1n9nFMNPutative blue light receptor/0.476
2xvv9DNSerum albumin/0.476
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.476
3hyoADPPyridoxal kinase/0.475
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.474
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.473
4eesFMNPhototropin-22.7.11.10.472
3lpbNVBTyrosine-protein kinase JAK2/0.471
4ji91M3Tyrosine-protein kinase JAK2/0.471
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
4blsAPCNTPase P4/0.468
5dkkFMNPredicted protein/0.468
2xvw9NRSerum albumin/0.464
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.464
1xddAAYIntegrin alpha-L/0.463
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.463
3b9lAZZSerum albumin/0.463
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3dds26BGlycogen phosphorylase, liver form2.4.1.10.462
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.461
3ddw055Glycogen phosphorylase, liver form2.4.1.10.461
4rpgFADUDP-galactopyranose mutase5.4.99.90.461
2ifaFMNUncharacterized protein/0.460
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.460
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
3f3sNADLambda-crystallin homolog/0.459
3u9eCOALmo1369 protein/0.459
1pqc444Oxysterols receptor LXR-beta/0.457
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.457
4eajATP5'-AMP-activated protein kinase subunit gamma-1/0.455
1n9lFMNPutative blue light receptor/0.454
3clsFADElectron transfer flavoprotein subunit alpha/0.454
4kukRBFPutative blue-light photoreceptor/0.453
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.453
3dd125DGlycogen phosphorylase, liver form2.4.1.10.452
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
4gxs0YSGlutamate receptor 2/0.452
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4hj4FMNLOV protein/0.451
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3t50FMNBlue-light-activated histidine kinase2.7.13.30.449
3zmmF9JTyrosine-protein kinase JAK2/0.449
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
2hckQUETyrosine-protein kinase HCK2.7.10.20.448
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4bb3KKAIsopenicillin N synthase1.21.3.10.448
1z6tADPApoptotic protease-activating factor 1/0.446
3c1y2BADNA integrity scanning protein DisA/0.446
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.446
2vcmM11Isopenicillin N synthase1.21.3.10.445
1dr3TAPDihydrofolate reductase1.5.1.30.444
1pdhFASp-hydroxybenzoate hydroxylase/0.444
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.444
2z6cFMNPhototropin-12.7.11.10.444
5e8ySTUTGF-beta receptor type-22.7.11.300.444
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.443
2ejzSAHDiphthine synthase/0.443
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.443
2pd7FADVivid PAS protein VVD/0.443
3q3cNADNAD-dependent L-serine dehydrogenase/0.443
3qxpX64Cyclin-dependent kinase 22.7.11.220.443
4fvqATPTyrosine-protein kinase JAK2/0.443
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
5e92ANPTGF-beta receptor type-22.7.11.300.442
1l7x700Glycogen phosphorylase, liver form2.4.1.10.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
3is2FADVivid PAS protein VVD/0.441
3nw3MU2Peptidoglycan recognition protein 1/0.441
4e5yNDPGDP-L-fucose synthase1.1.1.2710.440
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.440