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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.252

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2521.000
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.609
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.604
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.576
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.560
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.560
1ipeNDPTropinone reductase 21.1.1.2360.556
4j7uNAPSepiapterin reductase1.1.1.1530.545
4hwkNAPSepiapterin reductase1.1.1.1530.541
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.530
4j7xNAPSepiapterin reductase1.1.1.1530.516
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.515
5idwNAPShort-chain dehydrogenase/reductase SDR/0.514
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.513
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.510
1snyNAPLD36273p/0.509
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.509
1ae1NAPTropinone reductase 1/0.508
1oaaNAPSepiapterin reductase1.1.1.1530.507
4bmvNAPShort-chain dehydrogenase/0.502
3qrwNDPPutative ketoacyl reductase1.3.10.501
1x7gNAPPutative ketoacyl reductase1.3.10.499
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.498
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.497
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.494
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.492
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.492
5jlaNADPutative short-chain dehydrogenase/reductase/0.492
4qecNAPElxO/0.491
3p19NDPPutative blue fluorescent protein/0.489
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.488
1pr9NAPL-xylulose reductase1.1.1.100.488
1wntNAPL-xylulose reductase1.1.1.100.488
3tn7NJPShort-chain alcohol dehydrogenase/0.488
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.488
4fn4NADShort chain dehydrogenase/0.488
4yaiNAIC alpha-dehydrogenase/0.487
3l77NJPShort-chain alcohol dehydrogenase/0.486
1n5dNDPCarbonyl reductase [NADPH] 1/0.484
1xg5NAPDehydrogenase/reductase SDR family member 11/0.484
4dc1NDPPutative ketoacyl reductase1.3.10.484
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.483
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.482
2dteNAIGlucose 1-dehydrogenase related protein/0.481
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.479
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.478
3toxNAPPutative oxidoreductase/0.478
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.478
1w4zNAPPutative ketoacyl reductase1.3.10.477
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
2yutNAPPutative short-chain oxidoreductase/0.476
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.476
4gh5NADShort-chain dehydrogenase/reductase SDR/0.476
1x7hNDPPutative ketoacyl reductase1.3.10.474
4yagNAIC alpha-dehydrogenase/0.474
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.472
3s55NADPutative short-chain dehydrogenase/reductase/0.472
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.472
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.471
1iy8NADLevodione reductase/0.470
3gy0NAPNAD(P)-dependent oxidoreductase/0.470
2wsbNADGalactitol dehydrogenase/0.469
3sx2NADUncharacterized protein/0.469
1g6kNADGlucose 1-dehydrogenase1.1.1.470.467
2bd0NAPSepiapterin reductase/0.467
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.466
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
1xkqNDPUncharacterized protein/0.465
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.464
3sjuNDPKeto reductase/0.464
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.463
1rwbNADGlucose 1-dehydrogenase1.1.1.470.461
3wdsNADNADH-dependent quinuclidinone reductase/0.461
2jahNDPClavaldehyde dehydrogenase/0.460
3d3wNAPL-xylulose reductase1.1.1.100.458
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.457
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.455
2wdzNADGalactitol dehydrogenase/0.453
3ak4NADNADH-dependent quinuclidinone reductase/0.453
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.453
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.452
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.452
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.451
3lqfNADGalactitol dehydrogenase/0.449
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.448
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.447
4esoNAPPutative oxidoreductase/0.446
4qedNAPElxO/0.446
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.445
3vdqNAD3-hydroxybutyrate dehydrogenase/0.445
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.443
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.443
3bmoNAPPteridine reductase/0.442
3w8eNAD3-hydroxybutyrate dehydrogenase/0.442
5jydNADShort chain dehydrogenase/0.442
1sbyNADAlcohol dehydrogenase1.1.1.10.441
5lc1NADL-threonine 3-dehydrogenase/0.441
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.440
3rj5NADAlcohol dehydrogenase1.1.1.10.440
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.440