sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fls | WAY | Collagenase 3 | 3.4.24 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1fls | WAY | Collagenase 3 | 3.4.24 | 1.000 | |
| 1fm1 | WAY | Collagenase 3 | 3.4.24 | 0.704 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.522 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.510 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.498 | |
| 3ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.497 | |
| 1jk3 | BAT | Macrophage metalloelastase | 3.4.24.65 | 0.496 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.496 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.495 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.491 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.491 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.486 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.484 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.479 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.477 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.477 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.477 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.477 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.477 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.476 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.475 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.475 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.474 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.474 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.473 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.473 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.472 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.472 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.472 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.472 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.471 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.471 | |
| 2xs3 | ALA_PHE_THR_SER | Karilysin | 3.4.24 | 0.470 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.470 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.470 | |
| 1rm8 | BAT | Matrix metalloproteinase-16 | 3.4.24 | 0.469 | |
| 2e16 | SAH | Diphthine synthase | / | 0.469 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.469 | |
| 2srt | INH | Stromelysin-1 | 3.4.24.17 | 0.469 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.469 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.469 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.469 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.468 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.468 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.468 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.468 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.468 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.468 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.467 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.466 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.466 | |
| 2jnp | NGH | Stromelysin-1 | 3.4.24.17 | 0.466 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.466 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.466 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.465 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.465 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.465 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.464 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2dsg | SAH | Diphthine synthase | / | 0.464 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.462 | |
| 4ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.462 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.462 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.462 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.461 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.461 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.461 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.461 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.461 | |
| 3uph | 0C1 | Genome polyprotein | 2.7.7.48 | 0.461 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.460 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 2ejz | SAH | Diphthine synthase | / | 0.460 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.460 | |
| 3gnv | XNZ | Genome polyprotein | 2.7.7.48 | 0.460 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.460 | |
| 5dp2 | NAP | CurF | / | 0.460 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.459 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.459 | |
| 2ji7 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.459 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.458 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.458 | |
| 3ndj | JHZ | Methyltransferase | / | 0.458 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.457 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.457 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.457 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.457 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.457 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.457 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.457 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.456 | |
| 4e2y | JHZ | Methyltransferase | / | 0.456 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.456 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.455 | |
| 2huv | SAH | Diphthine synthase | / | 0.455 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.455 | |
| 4e32 | DWN | Methyltransferase | / | 0.455 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.454 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.454 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.454 | |
| 2ji6 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.454 | |
| 2p6l | SAH | Diphthine synthase | / | 0.454 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.454 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.454 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.454 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.453 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.453 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.453 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.453 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.453 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.453 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.452 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.452 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.452 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.452 | |
| 3hz6 | ADP | Xylulokinase | / | 0.452 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1wng | SAH | Diphthine synthase | / | 0.451 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.451 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.451 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.451 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.451 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.451 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 3ebi | BEY | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.451 | |
| 3ske | 054 | Genome polyprotein | 2.7.7.48 | 0.451 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.451 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1v93 | FAD | Methylenetetrahydrofolate reductase | / | 0.450 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.450 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.450 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.450 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.450 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.450 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.449 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.449 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.449 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.449 | |
| 2p6i | SAH | Diphthine synthase | / | 0.449 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3sff | 0DI | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.449 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4k39 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.449 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.449 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.449 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.448 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.448 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.448 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.448 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.448 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.448 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.448 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.448 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.448 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.448 | |
| 4xr9 | NAD | CalS8 | / | 0.448 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.447 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.447 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.447 | |
| 2dxw | SAH | Diphthine synthase | / | 0.447 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.447 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.447 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.447 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.447 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.447 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.447 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.447 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.447 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.446 | |
| 1cjw | COT | Serotonin N-acetyltransferase | / | 0.446 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.446 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1ty9 | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.446 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.446 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.446 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.445 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 1q3a | NGH | Stromelysin-2 | 3.4.24.22 | 0.445 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.445 | |
| 2e07 | SAH | Diphthine synthase | / | 0.445 | |
| 2el0 | SAH | Diphthine synthase | / | 0.445 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.445 | |
| 3p0e | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.445 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.445 | |
| 4ypu | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.445 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.444 | |
| 1kuy | COT | Serotonin N-acetyltransferase | / | 0.444 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.444 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.444 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.444 | |
| 5d4u | SAM | Uncharacterized protein MJ0489 | / | 0.444 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.443 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.443 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.443 | |
| 2dxx | SAH | Diphthine synthase | / | 0.443 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.443 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.443 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.443 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.443 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.442 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.442 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.442 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.442 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2dxv | SAH | Diphthine synthase | / | 0.442 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.442 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.442 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.442 | |
| 3hko | ANP | Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands | / | 0.442 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.442 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.442 | |
| 4l8u | 9AZ | Serum albumin | / | 0.442 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.441 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1mrk | FMC | Ribosome-inactivating protein alpha-trichosanthin | 3.2.2.22 | 0.441 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.441 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.441 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2ge3 | ACO | Probable acetyltransferase | / | 0.441 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3bmo | NAP | Pteridine reductase | / | 0.441 | |
| 3cne | FMN | Putative protease I | / | 0.441 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.441 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3zdu | 38R | Cyclin-dependent kinase-like 3 | 2.7.11.22 | 0.441 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.441 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 5doz | NDP | JamJ | / | 0.441 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1e0j | ANP | DNA primase/helicase | 2.7.7 | 0.440 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.440 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.440 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.440 | |
| 2egl | SAH | Diphthine synthase | / | 0.440 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2i47 | KGY | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.440 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.440 | |
| 3h2l | YAK | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.440 |