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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fkxPRHAdenosine deaminase3.5.4.4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fkxPRHAdenosine deaminase3.5.4.41.000
2adaHPRAdenosine deaminase3.5.4.40.826
1fkwPURAdenosine deaminase3.5.4.40.676
1v79FR7Adenosine deaminase3.5.4.40.559
1wxyFRKAdenosine deaminase3.5.4.40.549
1qxlFR8Adenosine deaminase3.5.4.40.538
1umlFR4Adenosine deaminase3.5.4.40.535
2z7gEH9Adenosine deaminase3.5.4.40.535
1uioHPRAdenosine deaminase3.5.4.40.534
1v7aFRCAdenosine deaminase3.5.4.40.533
1ndzFR5Adenosine deaminase3.5.4.40.528
1a4lDCFAdenosine deaminase3.5.4.40.522
1ndyFR3Adenosine deaminase3.5.4.40.512
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.487
1o5rFR9Adenosine deaminase3.5.4.40.475
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.475
1opbRETRetinol-binding protein 2/0.469
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
4eixNIMPhospholipase A2 VRV-PL-VIIIa/0.467
2xvw9NRSerum albumin/0.462
2bbqPFGThymidylate synthase/0.461
4equG6ISerine/threonine-protein kinase 102.7.11.10.461
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.460
2az3CDPNucleoside diphosphate kinase/0.459
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.459
3vtdTKDVitamin D3 receptor/0.459
4a0sCO8Octenoyl-CoA reductase/carboxylase/0.459
5cdtPFBAlcohol dehydrogenase E chain1.1.1.10.458
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.457
2bxmIMNSerum albumin/0.457
4m9aFDAAcyl-CoA dehydrogenase/0.457
1dnaCB3Thymidylate synthase/0.455
3is9AC7Gag-Pol polyprotein2.7.7.490.455
1db56INPhospholipase A2, membrane associated/0.454
1x8lOXRRetinol dehydratase/0.454
3pqbVGPPutative oxidoreductase/0.454
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
1cqp803Integrin alpha-L/0.453
1kceCB3Thymidylate synthase/0.453
3tm5SFGUncharacterized protein/0.453
3nj0PYVAbscisic acid receptor PYL2/0.451
4jdaA9SAbscisic acid receptor PYL3/0.450
1yhjR6CPyridoxal kinase2.7.1.350.449
4egnTWOCytochrome P450/0.449
4imfSI3N-acetylneuraminate lyase/0.449
4twnB96Ephrin type-A receptor 32.7.10.10.449
2gfsPQBMitogen-activated protein kinase 14/0.448
2ieaTDPPyruvate dehydrogenase E1 component1.2.4.10.448
3b9lAZZSerum albumin/0.448
3u8dU8DPhospholipase A2, membrane associated/0.448
5k2aZMAAdenosine receptor A2a/0.447
1xiuREARetinoic acid receptor RXR/0.446
3bgrT27Gag-Pol polyprotein2.7.7.490.446
3djfBC3Purine nucleoside phosphorylase/0.446
3i2834NBifunctional epoxide hydrolase 23.3.2.100.446
3itzP66Mitogen-activated protein kinase 14/0.446
3nefPYVAbscisic acid receptor PYL1/0.446
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.446
4nt3ZAWLactoperoxidase1.11.1.70.446
2ojg19AMitogen-activated protein kinase 12.7.11.240.445
2vmyFFOSerine hydroxymethyltransferase/0.445
2xvv9DNSerum albumin/0.445
3cqeP91Wee1-like protein kinase2.7.10.20.445
3tm4SAMUncharacterized protein/0.445
4qjqOTRLactoperoxidase/0.445
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.445
4u0zAPCAdenosine monophosphate-protein transferase FICD2.7.7.n10.445
1aiqCB3Thymidylate synthase/0.444
1ddtAPUDiphtheria toxin/0.444
2vagV25Dual specificity protein kinase CLK12.7.12.10.444
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.444
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.444
3wsbRWZFarnesyltransferase, putative/0.444
4ead0NPThymidine phosphorylase2.4.2.40.444
1kl2FONSerine hydroxymethyltransferase/0.443
1rx8FOLDihydrofolate reductase1.5.1.30.443
3ix8TX3Transcriptional activator protein LasR/0.443
3oafOAGDihydrofolate reductase1.5.1.30.443
4jlm1NNDeoxycytidine kinase2.7.1.740.443
4oicA8SBet v I allergen-like/0.443
4rtjSFGDNA adenine methylase2.1.1.720.443
4zasTYDCalS13/0.443
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1dr3HBIDihydrofolate reductase1.5.1.30.442
1hfqMOTDihydrofolate reductase1.5.1.30.442
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.442
3gwfFADCyclohexanone monooxygenase/0.442
3kjm245Cytokinin dehydrogenase 11.5.99.120.442
3uleC69Actin-related protein 3/0.442
3vg9ZMAAdenosine receptor A2a/0.442
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.442
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.442
1fmlRTLRetinol dehydratase/0.441
1synF89Thymidylate synthase/0.441
2fpcSCGStrictosidine synthase4.3.3.20.441
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.441
2w6pOA4Biotin carboxylase6.3.4.140.441
3bx5304Mitogen-activated protein kinase 14/0.441
3elySAHMethyltransferase/0.441
3qiyQI1Botulinum neurotoxin type A3.4.24.690.441
4fqsLYAThymidylate synthase ThyA/0.441
5cdgPFBAlcohol dehydrogenase E chain1.1.1.10.441
3emlZMAAdenosine receptor A2a/0.441
1dcyI3NPhospholipase A2, membrane associated/0.440
1itzTPPTransketolase, chloroplastic2.2.1.10.440
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.440
2bn4FADNADPH--cytochrome P450 reductase/0.440
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.440
2x7jTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.440
4a8v2ANMajor pollen allergen Bet v 1-J/0.440
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.440
4ia3BIVVitamin D3 receptor A/0.440