Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 1.000 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.556 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.552 | |
| 1rt5 | UC2 | Gag-Pol polyprotein | 2.7.7.49 | 0.542 | |
| 1tl1 | H18 | Gag-Pol polyprotein | 2.7.7.49 | 0.542 | |
| 2won | ZZE | Gag-Pol polyprotein | 2.7.7.49 | 0.540 | |
| 1tkt | H12 | Gag-Pol polyprotein | 2.7.7.49 | 0.532 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.531 | |
| 1tkz | H16 | Gag-Pol polyprotein | 2.7.7.49 | 0.530 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.529 | |
| 1hnv | TBO | Gag-Pol polyprotein | 2.7.7.49 | 0.528 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.526 | |
| 2jle | I15 | Reverse transcriptase/RNaseH | / | 0.526 | |
| 3t19 | 5MA | Gag-Pol polyprotein | 2.7.7.49 | 0.526 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.524 | |
| 3dmj | GWE | Pol protein | / | 0.519 | |
| 2vg7 | NNI | Gag-Pol polyprotein | 2.7.7.49 | 0.518 | |
| 3ffi | 3OB | Gag-Pol polyprotein | 2.7.7.49 | 0.518 | |
| 4rw6 | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.517 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.516 | |
| 1rt7 | UC4 | Gag-Pol polyprotein | 2.7.7.49 | 0.513 | |
| 3dlg | GWE | Gag-Pol polyprotein | 2.7.7.49 | 0.511 | |
| 1iky | MSD | Gag-Pol polyprotein | 2.7.7.49 | 0.510 | |
| 3dle | GFA | Gag-Pol polyprotein | 2.7.7.49 | 0.508 | |
| 3c6u | M22 | Gag-Pol polyprotein | 2.7.7.49 | 0.505 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.504 | |
| 4mfb | 29T | Gag-Pol polyprotein | 2.7.7.49 | 0.503 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.502 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.502 | |
| 1jlc | FTC | Gag-Pol polyprotein | 2.7.7.49 | 0.501 | |
| 1s1w | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.501 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.501 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.501 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.500 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.499 | |
| 4i2q | 1BT | Gag-Pol polyprotein | 2.7.7.49 | 0.499 | |
| 3dok | GWJ | Pol protein | / | 0.498 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.497 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.495 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.494 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.493 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.492 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.492 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.491 | |
| 1rt2 | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.490 | |
| 4h4o | 506 | Gag-Pol polyprotein | 2.7.7.49 | 0.490 | |
| 2ops | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.488 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.487 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.486 | |
| 2b5j | 3AC | Gag-Pol polyprotein | 2.7.7.49 | 0.486 | |
| 3lam | KRP | Gag-Pol polyprotein | 2.7.7.49 | 0.486 | |
| 4ig3 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.486 | |
| 1hni | AAA | Gag-Pol polyprotein | 2.7.7.49 | 0.485 | |
| 1rt1 | MKC | Gag-Pol polyprotein | 2.7.7.49 | 0.485 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.485 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.483 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 3dol | GWI | Pol protein | / | 0.483 | |
| 3drr | R8E | Gag-Pol polyprotein | 2.7.7.49 | 0.482 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.481 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.479 | |
| 1ikx | PNU | Gag-Pol polyprotein | 2.7.7.49 | 0.479 | |
| 2opr | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.479 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.478 | |
| 1tkx | GWB | Gag-Pol polyprotein | 2.7.7.49 | 0.476 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.476 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.475 | |
| 2hnz | PC0 | Gag-Pol polyprotein | 2.7.7.49 | 0.475 | |
| 2ynh | EUR | Gag-Pol polyprotein | 2.7.7.49 | 0.475 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.475 | |
| 1s1t | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.474 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.474 | |
| 3p9t | TCL | Repressor | / | 0.474 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.473 | |
| 2be2 | R22 | Gag-Pol polyprotein | 2.7.7.49 | 0.473 | |
| 3t1a | 5MA | Gag-Pol polyprotein | 2.7.7.49 | 0.473 | |
| 4ko0 | JLJ | Gag-Pol polyprotein | 2.7.7.49 | 0.473 | |
| 2vg5 | NNC | Gag-Pol polyprotein | 2.7.7.49 | 0.472 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 3meg | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.472 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.472 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.471 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 3i0s | RT7 | Gag-Pol polyprotein | 2.7.7.49 | 0.471 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 2opp | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.470 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.470 | |
| 4rw4 | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.470 | |
| 3drp | R8E | Gag-Pol polyprotein | 2.7.7.49 | 0.469 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.469 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.469 | |
| 1fk9 | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.468 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.468 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.467 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2opq | HBQ | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.466 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.466 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2nnl | ERD | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.465 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4id5 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.465 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.464 | |
| 3m8q | DJZ | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.464 | |
| 3zlo | X8U | Bcl-2-like protein 1 | / | 0.464 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.464 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.463 | |
| 2rht | C1E | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | 3.7.1.8 | 0.463 | |
| 4iae | 1DX | Alr2278 protein | / | 0.463 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.462 | |
| 3aba | FLI | Cytochrome P450 | / | 0.462 | |
| 3mee | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.462 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.462 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.461 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.461 | |
| 2rf2 | MRX | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 3qly | 55V | Uncharacterized protein | / | 0.461 | |
| 2ovm | AS0 | Progesterone receptor | / | 0.460 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.460 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.460 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.460 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.460 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.459 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1zdw | FLV | Prenyltransferase | / | 0.458 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.458 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.458 | |
| 3c6t | M14 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 3nbp | JGZ | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.458 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.458 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.458 | |
| 1eet | BFU | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 1jla | TNK | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.457 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.457 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.456 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.456 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.456 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.456 | |
| 3m8p | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 4ifv | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.456 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.456 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.455 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3tam | M06 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 4g1q | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.455 | |
| 4mry | CEI | Obelin | / | 0.455 | |
| 1rti | HEF | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.453 | |
| 1syn | F89 | Thymidylate synthase | / | 0.453 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.453 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.453 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.453 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.453 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 1rev | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.452 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.452 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.452 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.451 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.451 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.451 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2h00 | SAH | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase | / | 0.451 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.451 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.451 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.451 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.451 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.451 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.451 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1jlq | SBN | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.450 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.450 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2bxq | IMN | Serum albumin | / | 0.450 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.450 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.450 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.450 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1klm | SPP | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.449 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.449 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.449 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 4ask | K0I | Lysine-specific demethylase 6B | 1.14.11 | 0.449 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1m52 | P17 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.448 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.448 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.448 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.448 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.448 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.447 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.447 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.446 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.446 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.446 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.446 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.446 | |
| 4lb2 | DM5 | Serum albumin | / | 0.446 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 1q6p | 213 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.445 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.445 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 3bac | 3B9 | DNA ligase | / | 0.445 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.445 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.445 | |
| 5dju | FMN | NPH1-2 | / | 0.445 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.444 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2bxm | IMN | Serum albumin | / | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.444 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.444 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.444 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.444 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
| 2q6s | PLB | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3cse | N22 | Uncharacterized protein | / | 0.443 | |
| 3kqj | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.443 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.443 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 1err | RAL | Estrogen receptor | / | 0.442 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.442 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3i58 | 7NA | 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | / | 0.442 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.442 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.442 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.442 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.442 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4iah | 1DX | Alr2278 protein | / | 0.442 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2dpm | SAM | Modification methylase DpnIIA | 2.1.1.72 | 0.441 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.441 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.441 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.441 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.441 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.440 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.440 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.440 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2xvv | 9DN | Serum albumin | / | 0.440 | |
| 2xvw | 9NR | Serum albumin | / | 0.440 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4y1b | NAP | AntE | / | 0.440 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.440 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.440 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.440 |