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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fecFADTrypanothione reductase1.8.1.12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fecFADTrypanothione reductase1.8.1.121.000
1tytFADTrypanothione reductase1.8.1.120.708
4la1FADThioredoxin glutathione reductase/0.631
2hqmFADGlutathione reductase1.8.1.70.626
2jk6FADTrypanothione reductase/0.620
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.609
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.604
4dnaFADProbable glutathione reductase/0.604
1febFADTrypanothione reductase1.8.1.120.601
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.592
2wbaFADTrypanothione reductase1.8.1.120.586
1bzlFADTrypanothione reductase1.8.1.120.582
4nevFADTrypanothione reductase/0.576
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.573
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.572
3grsFADGlutathione reductase, mitochondrial1.8.1.70.568
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.567
1grhFADGlutathione reductase, mitochondrial1.8.1.70.566
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.564
2v6oFADThioredoxin glutathione reductase/0.558
1greFADGlutathione reductase, mitochondrial1.8.1.70.557
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.554
1grgFADGlutathione reductase, mitochondrial1.8.1.70.551
1gxfFADTrypanothione reductase1.8.1.120.547
4j56FADThioredoxin reductase 21.8.1.90.537
1typFADTrypanothione reductase1.8.1.120.535
4j57FADThioredoxin reductase 21.8.1.90.531
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.515
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.510
2wp5FADTrypanothione reductase/0.506
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.491
1graFADGlutathione reductase, mitochondrial1.8.1.70.491
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.484
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.482
4eqwFADCoenzyme A disulfide reductase/0.482
1zk7FADMercuric reductase1.16.1.10.481
1yqzFADCoenzyme A disulfide reductase/0.480
2eq6FADDihydrolipoyl dehydrogenase/0.475
2wowFADTrypanothione reductase/0.475
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.473
2eq8FADDihydrolipoyl dehydrogenase/0.468
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.467
2eq9FADDihydrolipoyl dehydrogenase/0.467
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.464
2w0hFADTrypanothione reductase/0.462
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.459
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.458
2tprFADTrypanothione reductase1.8.1.120.456
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.453
4eqsFADCoenzyme A disulfide reductase/0.449
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.448
2x8gFADThioredoxin glutathione reductase/0.447
1zx9FADMercuric reductase1.16.1.10.444
3icrFADCoenzyme A disulfide reductase/0.444