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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.621.000
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.679
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.580
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.526
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.499
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.492
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.484
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.477
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.477
4b2gV1NUncharacterized protein/0.473
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.462
1x8lOXRRetinol dehydratase/0.454
1h35R01Squalene--hopene cyclase4.2.1.1290.448
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1h36R88Squalene--hopene cyclase4.2.1.1290.447