sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fa0 | 3AT | Poly(A) polymerase | 2.7.7.19 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1fa0 | 3AT | Poly(A) polymerase | 2.7.7.19 | 1.000 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.526 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.520 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.510 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.510 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.499 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.494 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.493 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.492 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.491 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.491 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.489 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.487 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.486 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.486 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.486 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 3dsr | ADP | V-type ATP synthase beta chain | / | 0.484 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.483 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.483 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.482 | |
| 4iae | 1DX | Alr2278 protein | / | 0.482 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.480 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.480 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.480 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.480 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.480 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.480 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.479 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.479 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.479 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.479 | |
| 2piw | DHT | Androgen receptor | / | 0.479 | |
| 1fml | RTL | Retinol dehydratase | / | 0.478 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.478 | |
| 2xvv | 9DN | Serum albumin | / | 0.478 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.478 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.478 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.477 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.477 | |
| 1xj7 | DHT | Androgen receptor | / | 0.477 | |
| 1zdw | FLV | Prenyltransferase | / | 0.477 | |
| 2vuu | NAP | Nitrogen metabolite repression protein nmrA | / | 0.477 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.477 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.476 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.476 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.476 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.475 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.475 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.474 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.473 | |
| 2qpy | DHT | Androgen receptor | / | 0.473 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.473 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.473 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.472 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.472 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.471 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.471 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.471 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.471 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.471 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.470 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.470 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.470 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.470 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.470 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.470 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.469 | |
| 2egb | SAH | Diphthine synthase | / | 0.469 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.469 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.468 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.468 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.468 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.467 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.467 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.467 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.467 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.466 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.466 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.465 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.465 | |
| 2piv | DHT | Androgen receptor | / | 0.465 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.465 | |
| 1t74 | DHT | Androgen receptor | / | 0.464 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2jav | 5Z5 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.464 | |
| 2p2x | SAH | Diphthine synthase | / | 0.464 | |
| 2pix | DHT | Androgen receptor | / | 0.464 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 4b42 | 942 | Glucose-1-phosphate thymidylyltransferase | / | 0.464 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.463 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.463 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.463 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.463 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.463 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.463 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.462 | |
| 2z4j | DHT | Androgen receptor | / | 0.462 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.462 | |
| 4iah | 1DX | Alr2278 protein | / | 0.462 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.462 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.462 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.461 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.461 | |
| 2ejz | SAH | Diphthine synthase | / | 0.461 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.461 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.461 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 3q9o | NAD | Cholix toxin | 2.4.2.36 | 0.461 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.461 | |
| 4bgq | 38R | Cyclin-dependent kinase-like 5 | 2.7.11.22 | 0.461 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.461 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.461 | |
| 1el4 | CTZ | Obelin | / | 0.460 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.460 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.460 | |
| 2egs | SAH | Diphthine synthase | / | 0.460 | |
| 3eku | CY9 | Actin-5C | / | 0.460 | |
| 3i6i | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.460 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.460 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.460 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.459 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.459 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.459 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.458 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.458 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.458 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.458 | |
| 3qfr | FAD | NADPH--cytochrome P450 reductase | / | 0.458 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.458 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.457 | |
| 2pit | DHT | Androgen receptor | / | 0.457 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.457 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.457 | |
| 2w8y | 486 | Progesterone receptor | / | 0.457 | |
| 3cse | N22 | Uncharacterized protein | / | 0.457 | |
| 3d90 | NOG | Progesterone receptor | / | 0.457 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.457 | |
| 3zuy | TCH | Transporter | / | 0.457 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.457 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.457 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.456 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.456 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.456 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.456 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.456 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.456 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.455 | |
| 1t7r | DHT | Androgen receptor | / | 0.455 | |
| 2dsg | SAH | Diphthine synthase | / | 0.455 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.455 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.455 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.455 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.455 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4p6x | HCY | Glucocorticoid receptor | / | 0.455 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.454 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.454 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.454 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.454 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.454 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.454 | |
| 4kwh | NAP | Reductase homolog | / | 0.454 | |
| 4v12 | POG | MaoC like domain protein | / | 0.454 | |
| 5dp2 | NAP | CurF | / | 0.454 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.453 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 2pkl | DHT | Androgen receptor | / | 0.453 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.453 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.453 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.452 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1z4u | PH9 | Polyprotein | / | 0.452 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.452 | |
| 2uxi | G50 | HTH-type transcriptional regulator TtgR | / | 0.452 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.452 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.452 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.452 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.452 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3zux | TCH | Transporter | / | 0.452 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.452 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.452 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.451 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 2piu | DHT | Androgen receptor | / | 0.451 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.451 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.451 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.450 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.450 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 1s36 | CEI | Obelin | / | 0.450 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.450 | |
| 1t76 | DHT | Androgen receptor | / | 0.450 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.450 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.450 | |
| 2xvw | 9NR | Serum albumin | / | 0.450 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.450 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.450 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.450 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.450 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.450 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.450 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.449 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.449 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.449 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.449 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.449 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.449 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.449 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.449 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.449 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.449 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.449 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.448 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1uhj | CZB | Aequorin-2 | / | 0.448 | |
| 1vce | SAH | Diphthine synthase | / | 0.448 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.448 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.448 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.448 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.448 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.448 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.447 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.447 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.447 | |
| 1r2j | FAD | FkbI | / | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 2e08 | SAH | Diphthine synthase | / | 0.447 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.447 | |
| 2x86 | ADP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.447 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.447 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.447 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.447 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.447 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 5f12 | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.447 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 1gs4 | ZK5 | Androgen receptor | / | 0.446 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.446 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1m9r | INE | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.446 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.446 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.446 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.446 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.446 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.446 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 4ba5 | PXG | Probable aminotransferase | / | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.445 | |
| 2bxo | OPB | Serum albumin | / | 0.445 | |
| 2e8q | SAH | Diphthine synthase | / | 0.445 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.445 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.445 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.445 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.445 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.445 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.445 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.445 | |
| 4k5s | PM0 | Oxygenase | / | 0.445 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.445 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.444 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.444 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.444 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.444 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.444 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4oea | DHT | Androgen receptor | / | 0.444 | |
| 4y7c | FAD | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.443 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.443 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 2e8h | SAH | Diphthine synthase | / | 0.443 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.443 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.443 | |
| 2q7i | TES | Androgen receptor | / | 0.443 | |
| 2ykv | IK2 | Beta-transaminase | / | 0.443 | |
| 2ylq | TES | Androgen receptor | / | 0.443 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.443 | |
| 3gnq | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.443 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.443 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.443 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.443 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.443 | |
| 4y0k | NAP | AntE | / | 0.443 | |
| 1e81 | M91 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1tg5 | 645 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.442 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.442 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.442 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.442 | |
| 2huv | SAH | Diphthine synthase | / | 0.442 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.442 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.442 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.442 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.442 | |
| 4f9g | C2E | Stimulator of interferon genes protein | / | 0.442 | |
| 4iax | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.442 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.442 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.442 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.442 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.442 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.441 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.441 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.441 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.441 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3i6q | NDP | Putative leucoanthocyanidin reductase 1 | / | 0.441 | |
| 3jt6 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ivo | ACJ | Protoporphyrinogen oxidase | 1.3.3.4 | 0.441 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.441 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.440 | |
| 1mtc | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.440 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1t7t | DHT | Androgen receptor | / | 0.440 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.440 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.440 | |
| 2p8h | MY9 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2pir | DHT | Androgen receptor | / | 0.440 | |
| 2q0g | UPU | Poly(A) polymerase, putative | / | 0.440 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.440 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.440 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.440 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4bqu | CLR | Japanin | / | 0.440 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.440 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.440 |