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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1f28F89Thymidylate synthase2.1.1.45

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1f28F89Thymidylate synthase2.1.1.451.000
1synF89Thymidylate synthase/0.553
1ju6LYAThymidylate synthase2.1.1.450.513
1jujLYAThymidylate synthase2.1.1.450.513
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.512
1tsdF89Thymidylate synthase/0.489
2vf0F89Thymidylate synthase/0.485
1nceCB3Thymidylate synthase/0.482
1dnaCB3Thymidylate synthase/0.473
1jtqLY3Thymidylate synthase/0.472
1tlcF89Thymidylate synthase/0.469
1kzjCB3Thymidylate synthase/0.461
1f4fTP3Thymidylate synthase/0.459
2ftoCB3Thymidylate synthase/0.458
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.457
3bgxMEFThymidylate synthase/0.456
4fogC2FThymidylate synthase ThyA/0.455
4knzCB3Thymidylate synthase/0.455
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
1hvyD16Thymidylate synthase2.1.1.450.450
1kceCB3Thymidylate synthase/0.447
4foxD16Thymidylate synthase ThyA/0.447
3bhlTHGThymidylate synthase/0.445
1jutLYDThymidylate synthase/0.442
4ez8DHFThymidylate synthase2.1.1.450.440