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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.141.000
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.655
3oixFMNDihydroorotate dehydrogenase/0.542
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.505
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.493
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.491
4wzhFMNDihydroorotate dehydrogenase (fumarate)/0.487
3gyeFMNDihydroorotate dehydrogenase (fumarate)/0.486
2gjlFMNNitronate monooxygenase1.13.12.160.471
2givACOHistone acetyltransferase KAT8/0.470
4m83ERYOleandomycin glycosyltransferase2.4.10.470
3d91REMRenin3.4.23.150.467
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.466
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.466
4xq6FMNDihydroorotate dehydrogenase (quinone)/0.462
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
1lbcCYZGlutamate receptor 2/0.459
3vqsJT1Genome polyprotein/0.459
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.459
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.458
1xe65FPPlasmepsin-23.4.23.390.458
2ijgFADCryptochrome DASH, chloroplastic/mitochondrial/0.458
3a3gDLZLumazine protein/0.458
1w6hTITPlasmepsin-23.4.23.390.456
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.456
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.456
2emrSAHDiphthine synthase/0.455
3tjzGNPADP-ribosylation factor 1/0.455
4uymVOR14-alpha sterol demethylase Cyp51B/0.455
1xe55FEPlasmepsin-23.4.23.390.454
2vwqNAPGlucose 1-dehydrogenase/0.453
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
3gqvNAPEnoyl reductase LovC10.453
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
4isk1JYThymidylate synthase/0.453
5jlaNADPutative short-chain dehydrogenase/reductase/0.453
2ou2ACOHistone acetyltransferase KAT5/0.452
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.452
4k28NADShikimate dehydrogenase family protein/0.452
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.452
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.451
1tehNADAlcohol dehydrogenase class-31.1.1.10.450
1u3dFADCryptochrome-1/0.450
2a94AP0L-lactate dehydrogenase1.1.1.270.450
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.450
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.450
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.449
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.449
2z6rSAHDiphthine synthase/0.449
4bfxZVXPantothenate kinase2.7.1.330.449
6ctsCICCitrate synthase, mitochondrial2.3.3.10.449
1t2cNAIL-lactate dehydrogenase1.1.1.270.448
5d3qGDPDynamin-13.6.5.50.448
2djlFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.447
2iyfERYOleandomycin glycosyltransferase2.4.10.447
3f03FMNPentaerythritol tetranitrate reductase/0.447
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.447
4o1mNADEnoyl-acyl carrier reductase/0.447
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.446
3p82FMNPentaerythritol tetranitrate reductase/0.446
1i3lGDUUDP-glucose 4-epimerase/0.445
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.445
1rneC60Renin3.4.23.150.445
2dv4SAHDiphthine synthase/0.445
2f3rG5PGuanylate kinase2.7.4.80.445
2z3lPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.445
2eh5SAHDiphthine synthase/0.444
2w3bNDPDihydrofolate reductase1.5.1.30.444
2yxuATPPyridoxal kinase2.7.1.350.444
3t2kFADSulfide-quinone reductase/0.444
4kbyC2EStimulator of interferon genes protein/0.444
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.444
8dfrNDPDihydrofolate reductase1.5.1.30.444
1v35NAIEnoyl-ACP reductase/0.443
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
3ig6438Urokinase-type plasminogen activator3.4.21.730.443
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4loi1YCStimulator of interferon genes protein/0.443
4tm4FDAKtzI/0.443
1kp3ATPArgininosuccinate synthase6.3.4.50.442
1wc4APCAdenylate cyclase/0.442
3b6zCO7Enoyl reductase LovC10.442
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.442
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2dxwSAHDiphthine synthase/0.441
2e4nSAHDiphthine synthase/0.441
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3b70NAPEnoyl reductase LovC10.441
3icrFADCoenzyme A disulfide reductase/0.441
4ef9FMNDihydroorotate dehydrogenase (fumarate)/0.441
4q71FADBifunctional protein PutA/0.441
5cyoGDPSeptin-9/0.441
1cjuFOKAdenylate cyclase type 2/0.440
1cjuFOKAdenylate cyclase type 5/0.440
2ehlSAHDiphthine synthase/0.440
2g226IGRenin3.4.23.150.440
2gtbAZPOrf1ab polyprotein/0.440
2pswCOAN-alpha-acetyltransferase 50/0.440
3gw9VNILanosterol 14-alpha-demethylase/0.440
3toxNAPPutative oxidoreductase/0.440
4ambDUDPutative glycosyl transferase/0.440
4b79NADProbable short-chain dehydrogenase/0.440