sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1eir | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1eir | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 1.000 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.866 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.813 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.795 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.718 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.587 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.585 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.540 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.509 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.508 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.507 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.506 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.503 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.503 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.497 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.496 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.494 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.490 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.488 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.488 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.487 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.487 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.486 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.484 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.484 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.483 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.483 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.483 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1el4 | CTZ | Obelin | / | 0.482 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.481 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.481 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.480 | |
| 4kxj | P34 | Nucleoprotein | / | 0.480 | |
| 1s36 | CEI | Obelin | / | 0.479 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.479 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.478 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.478 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.477 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.476 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.475 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.475 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.474 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.473 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 1tys | DHF | Thymidylate synthase | / | 0.470 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.470 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.469 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.469 | |
| 1e2n | RCA | Thymidine kinase | / | 0.468 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.468 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.468 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.467 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.466 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.465 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.464 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.464 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.464 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.464 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.462 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.462 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.461 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.460 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.460 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.460 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.460 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4hcy | 0YN | Transketolase | / | 0.460 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.459 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.459 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.458 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.458 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.457 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.457 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.457 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.457 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 4nqg | CZH | Mitrocomin | / | 0.457 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.456 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.456 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.456 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.455 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.455 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.455 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.455 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.455 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.455 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.454 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2xwe | AMF | Glucosylceramidase | 3.2.1.45 | 0.454 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.454 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.453 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.453 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.453 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.453 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.453 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.453 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.452 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.452 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.452 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.452 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 2wgg | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.452 | |
| 3arp | DEQ | Chitinase A | / | 0.452 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.452 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.451 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.451 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.451 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.451 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.451 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.451 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.451 | |
| 1swt | BTN | Streptavidin | / | 0.450 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.450 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.450 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 2j41 | 5GP | Guanylate kinase | / | 0.450 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.450 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.450 | |
| 1dtp | APU | Diphtheria toxin | / | 0.449 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.449 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.449 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.449 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 4pzt | SOP | Histone acetyltransferase p300 | / | 0.449 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.448 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.448 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.448 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.448 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.447 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.447 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.447 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.447 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.447 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.447 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.447 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 3wth | IM4 | Acetylcholine-binding protein | / | 0.447 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.446 | |
| 1bzm | MZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 1dnp | MHF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.446 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.446 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.446 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.446 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.446 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.446 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.446 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.446 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 1lke | DOG | Bilin-binding protein | / | 0.445 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.445 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.445 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.445 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.445 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.445 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1uhh | CZP | Aequorin-2 | / | 0.444 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 2a5c | 8DA | Avidin | / | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.444 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.444 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.444 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 2xvv | 9DN | Serum albumin | / | 0.444 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.444 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.444 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3ogk | OGK | Coronatine-insensitive protein 1 | / | 0.444 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.444 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.444 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.444 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4pzs | ACO | Histone acetyltransferase p300 | / | 0.444 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.444 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.443 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.443 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.443 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2y88 | 2ER | Phosphoribosyl isomerase A | 5.3.1.16 | 0.443 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.443 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.443 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.443 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.442 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.442 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2ilu | NDP | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.442 | |
| 3arv | SAU | Chitinase A | / | 0.442 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.442 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.442 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.442 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.442 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.441 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.441 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3b9l | AZZ | Serum albumin | / | 0.441 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.441 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.441 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.441 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.440 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1sre | HAB | Streptavidin | / | 0.440 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.440 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.440 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3p9t | TCL | Repressor | / | 0.440 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.440 | |
| 4rxp | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.440 |