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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1efkNADNAD-dependent malic enzyme, mitochondrial1.1.1.38

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1efkNADNAD-dependent malic enzyme, mitochondrial1.1.1.381.000
1pj3NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.753
1pj2NAINAD-dependent malic enzyme, mitochondrial1.1.1.380.667
1do8NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.621
1eflNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.615
1pj4ATPNAD-dependent malic enzyme, mitochondrial1.1.1.380.545
1gz4ATPNAD-dependent malic enzyme, mitochondrial1.1.1.380.531
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.468
1gq2NAPNADP-dependent malic enzyme1.1.1.400.459
2a92NAIL-lactate dehydrogenase/0.453
1pzfA3DLactate dehydrogenase/0.452
2aa3AP0L-lactate dehydrogenase/0.449
3bmoNAPPteridine reductase/0.449
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.449
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.447
1rwbNADGlucose 1-dehydrogenase1.1.1.470.444
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.443
3d64NADAdenosylhomocysteinase/0.443
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.441
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.440