sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 1.000 | |
| 1osv | CHC | Bile acid receptor | / | 0.512 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.506 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.498 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.491 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.490 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.487 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.486 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.484 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.481 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.481 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.480 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.479 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.477 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.477 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.477 | |
| 1ppj | ANY | Cytochrome b | / | 0.476 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.475 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.474 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.474 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.474 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.474 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.473 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.473 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.473 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.473 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.472 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.472 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.472 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.472 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.471 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.471 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.470 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.469 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.469 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.468 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.468 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.467 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.466 | |
| 1q6s | 214 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.466 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.466 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.466 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.466 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.466 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.465 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.465 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.465 | |
| 4kqr | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.465 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.465 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.465 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.465 | |
| 5il1 | SAM | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.465 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.464 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2fzm | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.464 | |
| 4irn | FAD | AnaB | / | 0.464 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.463 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.463 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.462 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.462 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.462 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.462 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.462 | |
| 3iaa | TYD | CalG2 | / | 0.462 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.461 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.461 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.461 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.461 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.461 | |
| 3vqr | FAD | Putative oxidoreductase | / | 0.461 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.461 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.460 | |
| 1t90 | NAD | Malonate-semialdehyde dehydrogenase | 1.2.1.27 | 0.460 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.460 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.460 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.460 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.460 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.460 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.459 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.459 | |
| 4ask | K0I | Lysine-specific demethylase 6B | 1.14.11 | 0.459 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.459 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.458 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.458 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.458 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.458 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.458 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.458 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.458 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.458 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.457 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.457 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.457 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.457 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.457 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4ige | CHJ | Enoyl-acyl carrier reductase | / | 0.457 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.457 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.456 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.456 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.456 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.456 | |
| 2xlu | NA7 | Putative flavin-containing monooxygenase | / | 0.456 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.456 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.456 | |
| 3k7t | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.456 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.456 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 2avi | BTN | Avidin | / | 0.455 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.455 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.455 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.455 | |
| 1mrx | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.454 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.454 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.454 | |
| 3tfy | MET_LEU_GLY_PRO | N-alpha-acetyltransferase 50 | 2.3.1 | 0.454 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.454 | |
| 4xqc | NAD | Homospermidine synthase | 2.5.1.44 | 0.454 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.453 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.453 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.453 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.453 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.453 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.453 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.453 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 1o1v | TCH | Gastrotropin | / | 0.452 | |
| 1tys | DHF | Thymidylate synthase | / | 0.452 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.452 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.452 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.452 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 2rs1 | W84 | Genome polyprotein | / | 0.452 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.452 | |
| 2ym1 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.452 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.452 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.452 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.452 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.452 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.451 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.451 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.451 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1fml | RTL | Retinol dehydratase | / | 0.450 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.450 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.450 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.450 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.450 | |
| 4bj8 | BTN | Avidin | / | 0.450 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.450 | |
| 4u8l | FDA | UDP-galactopyranose mutase | / | 0.450 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.450 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.449 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.449 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.449 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.449 | |
| 3gqo | APR | Non-structural polyprotein | / | 0.449 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.449 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.449 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.449 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.449 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.449 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.449 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.449 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.449 | |
| 1g5q | ASP_SER_TYR_THR_CYS | Epidermin decarboxylase | 4.1.1 | 0.448 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.448 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.448 | |
| 3cif | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.448 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.448 | |
| 4kfp | 1R7 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.448 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.448 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.448 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1wwz | ACO | Uncharacterized protein | / | 0.447 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.447 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.447 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.447 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.447 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.447 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.447 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.447 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.447 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 4cj5 | 4VW | Integrase | / | 0.447 | |
| 4kqq | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.447 | |
| 4mzu | TYD | WxcM-like protein | / | 0.447 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.447 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.447 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.446 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.446 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.446 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.446 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.446 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.446 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.446 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.446 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.446 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.446 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.446 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.446 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.446 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1pn4 | HDC | Peroxisomal hydratase-dehydrogenase-epimerase | / | 0.445 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.445 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.445 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.445 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.445 | |
| 3lbe | COA | Uncharacterized protein | / | 0.445 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.445 | |
| 4ozn | ATP | Ammonium transporter | / | 0.445 | |
| 5doz | NDP | JamJ | / | 0.445 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1nmk | SFM | Peptidyl-prolyl cis-trans isomerase A | 5.2.1.8 | 0.444 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.444 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.444 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.444 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.444 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.444 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 2uxw | TH3 | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.9 | 0.444 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.444 | |
| 2x0e | TYD | WsaF | / | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.444 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.444 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.444 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.444 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.444 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.444 | |
| 1i75 | NOJ | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.443 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1qm5 | PLP | Maltodextrin phosphorylase | 2.4.1.1 | 0.443 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.443 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.443 | |
| 1zp3 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.443 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.443 | |
| 3nw3 | MU2 | Peptidoglycan recognition protein 1 | / | 0.443 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3ryp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.443 | |
| 3s5w | NAP | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.443 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.443 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.443 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.443 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.443 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.443 | |
| 4tm0 | NAP | KtzI | / | 0.443 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1eio | GCH | Gastrotropin | / | 0.442 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.442 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 2h2a | DND | Probable nicotinate-nucleotide adenylyltransferase | / | 0.442 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.442 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.442 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3mo0 | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.442 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3v2u | ATP | Protein GAL3 | / | 0.442 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.442 | |
| 4ap1 | FAD | Steroid monooxygenase | / | 0.442 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.442 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.441 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.441 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.441 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.441 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 2rgh | FAD | Alpha-Glycerophosphate Oxidase | / | 0.441 | |
| 3mkh | FAD | Nitroalkane oxidase | / | 0.441 | |
| 4e2b | FMN | Dehydrogenase | / | 0.441 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 4kq2 | U5P | Glycogen [starch] synthase isoform 2 | 2.4.1.11 | 0.441 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.441 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.441 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1dap | NDP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.440 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.440 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.440 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.440 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 2zul | SAM | Probable ribosomal RNA small subunit methyltransferase | / | 0.440 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3eku | CY9 | Actin-5C | / | 0.440 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.440 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.440 | |
| 3up3 | XCA | aceDAF-12 | / | 0.440 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.440 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.440 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 |