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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1e96GTPRas-related C3 botulinum toxin substrate 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1e96GTPRas-related C3 botulinum toxin substrate 1/1.000
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.582
4mitGTPRho-related protein racC/0.553
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.546
3lbnGNPGTPase HRas/0.544
3a58GNPGTP-binding protein RHO1/0.542
3v4fGNPGTPase HRas/0.540
4nyiGNPGTPase HRas/0.538
3nbzGTPGTP-binding nuclear protein Ran/0.536
4k81GTPGTPase HRas/0.535
3w3zGTPGTP-binding nuclear protein Ran/0.534
4lhwGNPRas-related protein Rab-8A/0.534
2c5lGTPGTPase HRas/0.533
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.531
4nyjGNPGTPase HRas/0.531
1zbdGTPRas-related protein Rab-3A/0.529
2rgeGNPGTPase HRas/0.529
3kz1GSPTransforming protein RhoA/0.529
5dhaGNPGTP-binding nuclear protein Ran/0.529
2rgbGNPGTPase HRas/0.527
2zetGTPRas-related protein Rab-27B/0.527
1t91GTPRas-related protein Rab-7a/0.526
4rkfGNPRas-related protein Rab-3/0.526
1s1cGNPTransforming protein RhoA/0.524
1xtsGTPGTP-binding protein Rheb/0.524
1yzqGNPRas-related protein Rab-6A/0.524
3a6pGTPGTP-binding nuclear protein Ran/0.524
1yhnGTPRas-related protein Rab-7a/0.523
3ddcGNPGTPase HRas/0.523
3e5hGNPRas-related protein Rab-28/0.523
5difGNPGTP-binding nuclear protein Ran/0.522
2fe4GDPRas-related protein Rab-6B/0.521
3oivGNPGTPase HRas/0.521
1g17GNPRas-related protein SEC4/0.520
2rgcGNPGTPase HRas/0.520
4dlwGNPGTPase HRas/0.520
1a2bGSPTransforming protein RhoA/0.518
5b2zGNPGTPase HRas/0.517
2gilGTPRas-related protein Rab-6A/0.516
4g0nGNPGTPase HRas/0.516
1vg8GNPRas-related protein Rab-7a/0.515
2gcpGSPRho-related GTP-binding protein RhoC/0.515
5hpyGDPTransforming protein RhoA/0.515
4dltGNPGTPase HRas/0.514
1xtrGNPGTP-binding protein Rheb/0.513
3lbhGNPGTPase HRas/0.513
3rs5GNPGTPase HRas/0.513
3kkoGNPRas-related protein M-Ras/0.512
3rabGNPRas-related protein Rab-3A/0.512
3l8yGNPGTPase HRas/0.511
3oesGNPGTPase RhebL1/0.511
3bbpGTPRas-related protein Rab-6A/0.510
4o25GTPGTP-binding protein Rheb/0.509
5jljGNPGTP-binding nuclear protein Ran/0.508
1ibrGNPGTP-binding nuclear protein Ran/0.507
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.506
3oiuGNPGTPase HRas/0.506
3oiwGNPGTPase HRas/0.505
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.504
3pitGNPRas-related protein M-Ras/0.504
4dlxGNPGTPase HRas/0.504
3tsoGNPRas-related protein Rab-25/0.503
3rs0GNPGTPase HRas/0.501
4dlzGNPGTPase HRas/0.500
4hdoGNPRas-related protein Rap-1b/0.500
1kmqGNPTransforming protein RhoA/0.499
1m7bGTPRho-related GTP-binding protein RhoE/0.497
3i3sGNPGTPase HRas/0.497
3rs7GNPGTPase HRas/0.497
3kucGDPRas-related protein Rap-1A/0.496
3eg5GNPCell division control protein 42 homolog/0.495
3lawGNPRas-related protein Rab-7a/0.494
3tnfGNPRas-related protein Rab-8A/0.494
1cxzGSPTransforming protein RhoA/0.493
3ea5GDPGTP-binding nuclear protein Ran/0.493
3rs4GNPGTPase HRas/0.493
4js0GNPCell division control protein 42 homolog/0.493
3kudGDPGTPase HRas/0.492
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.491
3lbiGNPGTPase HRas/0.489
1zc4GNPRas-related protein Ral-A/0.488
1zd9GDPADP-ribosylation factor-like protein 8A/0.488
2bkuGTPGTP-binding nuclear protein Ran/0.488
3th5GNPRas-related C3 botulinum toxin substrate 1/0.488
1k5dGNPGTP-binding nuclear protein Ran/0.487
1z2cGNPRho-related GTP-binding protein RhoC/0.487
4dsnGCPGTPase KRas/0.486
4xoiGTPTransforming protein RhoA/0.486
3rslGNPGTPase HRas/0.484
1zc3GNPRas-related protein Ral-A/0.481
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.481
3k8yGNPGTPase HRas/0.481
2ffqGSPRas-related protein Rab-6B/0.480
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.480
3x1zGNPRas-related protein Rap-1b/0.478
3bc1GNPRas-related protein Rab-27A/0.475
4dlsGNPGTPase HRas/0.474
3cphGDPRas-related protein SEC4/0.473
4l9wGNPGTPase HRas/0.470
4qxaGTPRas-related protein Rab-9A/0.469
4dlvGNPGTPase HRas/0.465
4xvqGNPGTPase HRas/0.465
1ow3GDPTransforming protein RhoA/0.463
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.463
4xvrGNPGTPase HRas/0.461
4cymGCPRas-related protein Rab-32/0.459
2fg5GNPRas-related protein Rab-31/0.458
4ol0GTPGTP-binding nuclear protein Ran/0.458
3wyfGTPGTP-binding nuclear protein/0.457
4hdqGNPRas-related protein Rap-1b/0.457
4uj3GNPRas-related protein Rab-11A/0.457
1uadGNPRas-related protein Ral-A/0.455
3mjhGTPRas-related protein Rab-5A/0.455
1oixGDPRas-related protein Rab-11A/0.454
1gwnGTPRho-related GTP-binding protein RhoE/0.453
4o2lGTPGTP-binding protein Rheb/0.452
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.450
3tklGTPRas-related protein Rab-1A/0.450
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.447
3qbtGNPRas-related protein Rab-8A/0.447
1lfdGNPGTPase HRas/0.446
4lucGDPGTPase KRas/0.446
2rggGNPGTPase HRas/0.442
3tgpGNPGTPase HRas/0.442
1bmfANPATP synthase subunit alpha, mitochondrial/0.441
1bmfANPATP synthase subunit beta, mitochondrial3.6.3.140.441
4kvgGTPRas-related protein Rap-1A/0.440
4o2rGDPGTP-binding protein Rheb/0.440