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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1e8mP0HProlyl endopeptidase3.4.21.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1e8mP0HProlyl endopeptidase3.4.21.261.000
4bcdTDVProlyl endopeptidase3.4.21.260.803
1uopGLY_PHE_GLU_PROProlyl endopeptidase3.4.21.260.692
1uoqGLU_PHE_SER_PROProlyl endopeptidase3.4.21.260.667
1uooGLY_PHE_ARG_PROProlyl endopeptidase3.4.21.260.562
3eq9X97Prolyl endopeptidase3.4.21.260.554
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.468
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.453
2pobGW4Peroxisome proliferator-activated receptor gamma/0.451
1rdt570Peroxisome proliferator-activated receptor gamma/0.446
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.446
4b64FADL-ornithine N(5)-monooxygenase/0.444
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3hyoADPPyridoxal kinase/0.441
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.440