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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1e63FADFerredoxin--NADP reductase1.18.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1e63FADFerredoxin--NADP reductase1.18.1.21.000
1qgzFADFerredoxin--NADP reductase1.18.1.20.807
1e64FADFerredoxin--NADP reductase1.18.1.20.715
1qgyFADFerredoxin--NADP reductase1.18.1.20.683
1queFADFerredoxin--NADP reductase1.18.1.20.675
1bjkFADFerredoxin--NADP reductase1.18.1.20.674
1qh0FADFerredoxin--NADP reductase1.18.1.20.669
1e62FADFerredoxin--NADP reductase1.18.1.20.650
1h85FADFerredoxin--NADP reductase1.18.1.20.645
4bprFADFerredoxin--NADP reductase1.18.1.20.642
1ogiFADFerredoxin--NADP reductase1.18.1.20.641
4c43FADFerredoxin--NADP reductase1.18.1.20.640
1h42FADFerredoxin--NADP reductase1.18.1.20.625
1ogjFADFerredoxin--NADP reductase1.18.1.20.613
2b5oFADFerredoxin--NADP reductase1.18.1.20.612
1gr1FADFerredoxin--NADP reductase1.18.1.20.607
3zbtFADFerredoxin--NADP reductase1.18.1.20.606
1gjrFADFerredoxin--NADP reductase1.18.1.20.603
1go2FADFerredoxin--NADP reductase1.18.1.20.597
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.590
1b2rFADFerredoxin--NADP reductase1.18.1.20.584
3zc3FADFerredoxin--NADP reductase1.18.1.20.581
3qfcFADNADPH--cytochrome P450 reductase/0.577
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.575
1ewyFADFerredoxin--NADP reductase1.18.1.20.574
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.573
3vo2FADFerredoxin--NADP reductase/0.573
1gawFADFerredoxin/0.563
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.555
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.555
2rc6FADFerredoxin--NADP reductase/0.554
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.554
1w35FADFerredoxin--NADP reductase1.18.1.20.553
1sm4FADFerredoxin--NADP reductase/0.552
1gaqFADFerredoxin/0.551
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.549
3qe2FADNADPH--cytochrome P450 reductase/0.543
1w87FADFerredoxin--NADP reductase1.18.1.20.541
3w5uFADFerredoxin/0.540
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.528
2piaFMNPhthalate dioxygenase reductase/0.527
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.526
3qftFADNADPH--cytochrome P450 reductase/0.521
4y9uFADNADPH--cytochrome P450 reductase/0.517
3fpkFADFerredoxin-NADP reductase/0.515
2rc5FADFerredoxin--NADP reductase/0.512
1j9zFADNADPH--cytochrome P450 reductase/0.504
1amoFADNADPH--cytochrome P450 reductase/0.503
4y7cFADNADPH--cytochrome P450 reductase/0.503
3qfsFADNADPH--cytochrome P450 reductase/0.502
3jqrFADFerredoxin--NADP reductase, apicoplast/0.495
1gvhFADFlavohemoprotein/0.494
4yaoFADNADPH--cytochrome P450 reductase/0.494
3ojxFADNADPH--cytochrome P450 reductase/0.491
4y9rFADNADPH--cytochrome P450 reductase/0.491
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.487
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.487
1ja1FADNADPH--cytochrome P450 reductase/0.485
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.481
4yauFADNADPH--cytochrome P450 reductase/0.480
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2bpoFADNADPH--cytochrome P450 reductase/0.477
2bf4FADNADPH--cytochrome P450 reductase/0.476
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.476
3wqmB29Diterpene synthase3.1.7.80.474
3p2oNADBifunctional protein FolD/0.469
4bfuZVUPantothenate kinase2.7.1.330.468
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.468
4n4wSNTSmoothened homolog/0.467
4rkdKETAminotransferase/0.465
4bfxZVXPantothenate kinase2.7.1.330.464
5a4vQUEGlutathione S-transferase F22.5.1.180.464
1g63FMNEpidermin decarboxylase4.1.10.463
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.463
4b2gV1NUncharacterized protein/0.463
3iktNADRedox-sensing transcriptional repressor Rex/0.462
4bftZVTPantothenate kinase2.7.1.330.462
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.461
2vd0D27Hematopoietic prostaglandin D synthase/0.461
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.461
5dp2NAPCurF/0.461
2g8yNADHydroxycarboxylate dehydrogenase B/0.460
4yafFADNADPH--cytochrome P450 reductase/0.460
5irnADPNucleotide binding oligomerization domain containing 2/0.460
2ok8FADFerredoxin--NADP reductase, apicoplast/0.459
3phjDHKShikimate dehydrogenase (NADP(+))/0.459
4j7hTRHPCZA361.3/0.459
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.459
2hq9FADMll6688 protein/0.458
3br3ETHTH-type transcriptional regulator QacR/0.458
3zcbATPAdenosine monophosphate-protein transferase VbhT2.7.7.n10.458
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
4kbyC2EStimulator of interferon genes protein/0.458
1cqxFADFlavohemoprotein/0.457
1f20FADNitric oxide synthase, brain1.14.13.390.457
1mvsDTMDihydrofolate reductase1.5.1.30.457
2bf4FMNNADPH--cytochrome P450 reductase/0.457
4cdmFO1Deoxyribodipyrimidine photolyase/0.457
4hcy0YNTransketolase/0.457
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
2vn1FK5Peptidylprolyl isomerase/0.456
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.456
5ah5LSSLeucine--tRNA ligase/0.456
1pq944BOxysterols receptor LXR-beta/0.455
1vbiNADMalate/L-lactate dehydrogenase family protein/0.455
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.455
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.455
3ivcFG4Pantothenate synthetase6.3.2.10.454
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.453
3adaNADSubunit alpha of sarocosine oxidase/0.453
1pqc444Oxysterols receptor LXR-beta/0.452
1tllFMNNitric oxide synthase, brain1.14.13.390.452
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.452
4dyn0MRNucleoprotein/0.452
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.451
1lnmDTXBilin-binding protein/0.450
3fznD7KBenzoylformate decarboxylase4.1.1.70.450
3nutSAHPrecorrin-3 methylase/0.450
4i1c1BEBeta-secretase 13.4.23.460.450
1gky5GPGuanylate kinase2.7.4.80.449
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.449
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.449
3dwbRDFEndothelin-converting enzyme 13.4.24.710.449
3rtnRTNBeta-secretase 13.4.23.460.449
4bfvZVVPantothenate kinase2.7.1.330.449
4e2yJHZMethyltransferase/0.449
4z87GDPInosine-5'-monophosphate dehydrogenase/0.449
2qimZEAClass 10 plant pathogenesis-related protein/0.448
2vnjFADNADPH:ferredoxin reductase/0.448
3jzdNADMaleylacetate reductase/0.448
3ske054Genome polyprotein2.7.7.480.448
1tllFADNitric oxide synthase, brain1.14.13.390.447
2gv8NDPThiol-specific monooxygenase1.14.130.447
3c1oNAPEugenol synthase/0.447
3kp4MIITranscriptional regulator TcaR/0.447
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.447
1r58AO5Methionine aminopeptidase 2/0.446
1x1cSAHC-20 methyltransferase/0.446
2hxzH7JCathepsin S3.4.22.270.446
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.446
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.446
1ja0FADNADPH--cytochrome P450 reductase/0.445
2w02ATPAcsD/0.445
4b4w9L9Bifunctional protein FolD/0.445
1a8pFADFerredoxin--NADP reductase/0.444
3gwfFADCyclohexanone monooxygenase/0.444
3n3aFMNProtein NrdI/0.444
3rgaILDEpoxide hydrolase LasB5.5.10.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
4b4vL34Bifunctional protein FolD/0.444
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.444
4j7gTRHPCZA361.3/0.444
4xoqF42Coenzyme F420:L-glutamate ligase/0.444
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.443
1obnASVIsopenicillin N synthase1.21.3.10.443
2fsvNAPNAD(P) transhydrogenase subunit beta1.6.1.20.443
3gwfNAPCyclohexanone monooxygenase/0.443
3qwbNDPProbable quinone oxidoreductase1.6.5.50.443
4rvdSAMD-mycarose 3-C-methyltransferase/0.443
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1pd9CO4Dihydrofolate reductase1.5.1.30.442
1wv4FMNPyridoxine/pyridoxamine 5'-phosphate oxidase/0.442
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
4acxS8ZBeta-secretase 13.4.23.460.442
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.442
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.442
2ejzSAHDiphthine synthase/0.441
2lfoGCHFatty acid-binding protein, liver/0.441
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.441
3uph0C1Genome polyprotein2.7.7.480.441
4f5yC2EStimulator of interferon genes protein/0.441
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.440
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.440
3ojwFADNADPH--cytochrome P450 reductase/0.440
3v2uATPProtein GAL3/0.440
4ba5PXGProbable aminotransferase/0.440
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.440