Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 1.000 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.834 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.789 | |
| 1gr1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.737 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.725 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.693 | |
| 1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.679 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.676 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.653 | |
| 4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.651 | |
| 1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.643 | |
| 1w35 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.640 | |
| 3zbt | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.632 | |
| 1fnc | FDA | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.630 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.630 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.618 | |
| 1gaw | FAD | Ferredoxin | / | 0.614 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.611 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.610 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.607 | |
| 1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.603 | |
| 2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.603 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.598 | |
| 1qh0 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.596 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.596 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.595 | |
| 1gaq | FAD | Ferredoxin | / | 0.594 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.594 | |
| 1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.590 | |
| 1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.589 | |
| 1h85 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.587 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.580 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.579 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.570 | |
| 3w5u | FAD | Ferredoxin | / | 0.553 | |
| 1ewy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.552 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.538 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.538 | |
| 3qe2 | FAD | NADPH--cytochrome P450 reductase | / | 0.535 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.533 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.530 | |
| 1b2r | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.527 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.526 | |
| 4uaj | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.510 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.509 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.507 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.507 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.507 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.506 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.505 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.505 | |
| 2pia | FMN | Phthalate dioxygenase reductase | / | 0.502 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.502 | |
| 3qfs | FAD | NADPH--cytochrome P450 reductase | / | 0.498 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.498 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.497 | |
| 3bus | SAH | Demethylrebeccamycin-D-glucose O-methyltransferase | / | 0.497 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.493 | |
| 2rc5 | FAD | Ferredoxin--NADP reductase | / | 0.492 | |
| 4yao | FAD | NADPH--cytochrome P450 reductase | / | 0.492 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.491 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.491 | |
| 4y7c | FAD | NADPH--cytochrome P450 reductase | / | 0.490 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.489 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.488 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.487 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.486 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.486 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.486 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.485 | |
| 4y9u | FAD | NADPH--cytochrome P450 reductase | / | 0.485 | |
| 2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.484 | |
| 2ejz | SAH | Diphthine synthase | / | 0.483 | |
| 4yaf | FAD | NADPH--cytochrome P450 reductase | / | 0.483 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.482 | |
| 3ske | 054 | Genome polyprotein | 2.7.7.48 | 0.482 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.482 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 4yau | FAD | NADPH--cytochrome P450 reductase | / | 0.481 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.480 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.480 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.480 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.478 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 4y9r | FAD | NADPH--cytochrome P450 reductase | / | 0.478 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.477 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.477 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.477 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.476 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.475 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.475 | |
| 1dia | L24 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.474 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.474 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.474 | |
| 4rkd | KET | Aminotransferase | / | 0.474 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.473 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.473 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.473 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.472 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.472 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.471 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.471 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.471 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.470 | |
| 4n4w | SNT | Smoothened homolog | / | 0.470 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.469 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.469 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.469 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.469 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.468 | |
| 2gci | MRR | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.467 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.467 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.466 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.466 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.466 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.466 | |
| 3nt5 | NAI | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.466 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.466 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.465 | |
| 3c1o | NAP | Eugenol synthase | / | 0.465 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.465 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.465 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.464 | |
| 1vce | SAH | Diphthine synthase | / | 0.464 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.464 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.464 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.464 | |
| 4j7h | TRH | PCZA361.3 | / | 0.464 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.463 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.463 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.463 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.462 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.462 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 2dsg | SAH | Diphthine synthase | / | 0.461 | |
| 2y01 | Y00 | Beta-1 adrenergic receptor | / | 0.461 | |
| 3e78 | TPP | High affinity transport system protein p37 | / | 0.461 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4b67 | FAD | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 4j17 | 1HQ | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.461 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.460 | |
| 1qcj | APT | Antiviral protein I | 3.2.2.22 | 0.460 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.460 | |
| 2r6h | FAD | Na(+)-translocating NADH-quinone reductase subunit F | / | 0.460 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.460 | |
| 3e6e | DCS | Alanine racemase | / | 0.460 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.460 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.459 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.459 | |
| 3anm | SYD | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.459 | |
| 3gyn | B42 | Genome polyprotein | 2.7.7.48 | 0.459 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.459 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.459 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.458 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.458 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.458 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 2zts | ADP | Uncharacterized protein | / | 0.458 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.458 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.458 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.457 | |
| 2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.457 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.457 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.457 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.457 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.457 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.457 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.457 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.457 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.456 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.456 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 2ejk | SAH | Diphthine synthase | / | 0.456 | |
| 2w02 | ATP | AcsD | / | 0.456 | |
| 3bnk | FMN | Flavoredoxin | / | 0.456 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.456 | |
| 3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.456 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.455 | |
| 2emu | SAH | Diphthine synthase | / | 0.455 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 3ojw | FAD | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.454 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.454 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.454 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.454 | |
| 2p6d | SAH | Diphthine synthase | / | 0.454 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.454 | |
| 3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 3ox2 | 79X | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 4ac0 | MIY | Tetracycline repressor protein class B from transposon Tn10 | / | 0.454 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.454 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.454 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.453 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.453 | |
| 2e16 | SAH | Diphthine synthase | / | 0.453 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.453 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.453 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.453 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.453 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.453 | |
| 4phl | PIL | Phosphodiesterase | / | 0.453 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.453 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.452 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.452 | |
| 2npf | MOU | Elongation factor 2 | / | 0.452 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.452 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.452 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.452 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.452 | |
| 4nzh | FAD | L-ornithine N(5)-monooxygenase | / | 0.452 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.451 | |
| 1fdr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.451 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.451 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.451 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.451 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.451 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.451 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.451 | |
| 2xda | JPS | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.451 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.451 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.451 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.451 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.451 | |
| 4nwi | CTN | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.451 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.450 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.450 | |
| 2re8 | GSU | Glutamine--tRNA ligase | 6.1.1.18 | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3tyv | HI3 | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.450 | |
| 5doz | NDP | JamJ | / | 0.450 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.449 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.449 | |
| 1til | ATP | Anti-sigma F factor | / | 0.449 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.449 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.449 | |
| 2cb3 | MLD | Peptidoglycan-recognition protein LE | / | 0.449 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.449 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 4e32 | DWN | Methyltransferase | / | 0.449 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.449 | |
| 4qoh | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.449 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.449 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.448 | |
| 1cqx | FAD | Flavohemoprotein | / | 0.448 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.448 | |
| 2po3 | T4K | 4-dehydrase | / | 0.448 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.448 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.448 | |
| 4tm1 | FDA | KtzI | / | 0.448 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.447 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.447 | |
| 3aho | 3A2 | Oligopeptidase | / | 0.447 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3uic | 09T | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 5f54 | TMP | Single-stranded-DNA-specific exonuclease | / | 0.447 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1yun | ATP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.446 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.446 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.446 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.446 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.446 | |
| 2nr4 | FMN | Conserved protein | / | 0.446 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.446 | |
| 4mka | 2AY | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.446 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.446 | |
| 5fx2 | FMN | Flavodoxin | / | 0.446 | |
| 5h86 | BCO | Histone acetyltransferase KAT2A | 2.3.1.48 | 0.446 | |
| 1cm0 | COA | Histone acetyltransferase KAT2B | 2.3.1.48 | 0.445 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.445 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.445 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.445 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.445 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.445 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.445 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.445 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.445 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.445 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.445 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.445 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 5dp2 | NAP | CurF | / | 0.445 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.444 | |
| 1s4o | GDP | Glycolipid 2-alpha-mannosyltransferase | / | 0.444 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.444 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1z4r | ACO | Histone acetyltransferase KAT2A | 2.3.1.48 | 0.444 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 2gmu | PDG | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.444 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.444 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3n71 | SFG | Histone-lysine N-methyltransferase Smyd1 | / | 0.444 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.444 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.444 | |
| 4l7h | 1W1 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.443 | |
| 1e79 | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 1e79 | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.443 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 2ehl | SAH | Diphthine synthase | / | 0.443 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 2owv | SAH | Diphthine synthase | / | 0.443 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.443 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.443 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.443 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.443 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.443 | |
| 4rxp | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 4tla | ADP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.443 | |
| 4to5 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.442 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.442 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.442 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 3dwb | RDF | Endothelin-converting enzyme 1 | 3.4.24.71 | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3ei8 | PL5 | LL-diaminopimelate aminotransferase, chloroplastic | / | 0.442 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.442 | |
| 3ox3 | 4X4 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 4ba5 | PXG | Probable aminotransferase | / | 0.442 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.442 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.442 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.442 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.441 | |
| 1nqw | 5YL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2giq | NN2 | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.441 | |
| 2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.441 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.441 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.441 | |
| 2zbz | VDX | Vitamin D3 dihydroxylase | / | 0.441 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.441 | |
| 3bsc | 2PD | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.441 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3eks | CY9 | Actin-5C | / | 0.441 | |
| 3frk | TQP | QdtB | / | 0.441 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.441 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 3v0n | 4GW | Histo-blood group ABO system transferase | / | 0.441 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.441 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4k1x | FAD | NADPH:ferredoxin reductase | / | 0.441 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.441 | |
| 1eje | FMN | Protein MTH_152 | / | 0.440 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.440 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1odj | GMP | Purine nucleoside phosphorylase | / | 0.440 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.440 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.440 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.440 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.440 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.440 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.440 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.440 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 4isu | IKM | Glutamate receptor 2 | / | 0.440 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4was | COO | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.440 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.440 |