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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1e2kTMCThymidine kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1e2kTMCThymidine kinase/1.000
4ivrN50Thymidine kinase/0.525
4ivqI43Thymidine kinase/0.524
1e2nRCAThymidine kinase/0.522
3m0wP77Protein S100-A4/0.495
4jx1CAHCamphor 5-monooxygenase1.14.15.10.488
4jx1CAMCamphor 5-monooxygenase1.14.15.10.467
3ts1TYATyrosine--tRNA ligase6.1.1.10.465
3bmnAX3Pteridine reductase/0.463
3c35KAIGlutamate receptor ionotropic, kainate 1/0.459
2r0cFADPutative FAD-monooxygenase/0.454
3gwuSRENa(+):neurotransmitter symporter (Snf family)/0.454
1wbsLI2Mitogen-activated protein kinase 14/0.453
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.453
2qboCAMCamphor 5-monooxygenase1.14.15.10.452
3cr0809Wee1-like protein kinase2.7.10.20.452
1n75ATPGlutamate--tRNA ligase6.1.1.170.451
3n0tOPYDipeptidyl peptidase 23.4.14.20.451
4a87NARMajor pollen allergen Bet v 1-A/0.449
1ot3THMDeoxynucleoside kinase/0.448
1ve3SAMUncharacterized protein/0.447
2bryFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.447
1bcpATPPertussis toxin subunit 4/0.446
1bcpATPPertussis toxin subunit 5/0.446
2b0qADPAminoglycoside 3'-phosphotransferase2.7.1.950.446
3ko0TFPProtein S100-A4/0.446
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.446
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.446
1g8oU5PN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.445
2zevB71Geranylgeranyl pyrophosphate synthase/0.443
1w7h3IPMitogen-activated protein kinase 14/0.442
5fdg0N8Polymerase acidic protein/0.442
1ja0FMNNADPH--cytochrome P450 reductase/0.441
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.441
1g93UPGN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.440
3fx6BPXCarboxypeptidase A13.4.17.10.440
4burNADApoptosis-inducing factor 1, mitochondrial1.1.10.440
3qakUKAAdenosine receptor A2a/0.440