sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.851 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.794 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.759 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.653 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.625 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.620 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.610 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.608 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.605 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.604 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.601 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.593 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.590 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.571 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.567 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.567 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.562 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.557 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.550 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.533 | |
| 1j3j | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.524 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.516 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.496 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.493 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.492 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.490 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.490 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.488 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.487 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.486 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.485 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.483 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.482 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.480 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.479 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.476 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.476 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.476 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.475 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.475 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.473 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.472 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.471 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.470 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.470 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.469 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.469 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.468 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.468 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.468 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.467 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.466 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.466 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.466 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.466 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.465 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.465 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.465 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.464 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.464 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.464 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.463 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.463 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.463 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.462 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.461 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.461 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.461 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.461 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.461 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.460 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.460 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.459 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.459 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.458 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.458 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.458 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.458 | |
| 4dja | FAD | (6-4) photolyase | / | 0.458 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.458 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.457 | |
| 2hqp | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.457 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.457 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.457 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.457 | |
| 4irn | FAD | AnaB | / | 0.457 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.456 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.456 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.456 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.455 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.455 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.455 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.455 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 3awh | FMN | FMN-binding protein | / | 0.454 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.454 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.454 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.453 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.453 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.453 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.453 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.452 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.452 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.452 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.452 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.452 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.452 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.452 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 1osv | CHC | Bile acid receptor | / | 0.451 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.451 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.451 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.451 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.451 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.450 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.450 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 2e83 | FMN | FMN-binding protein | / | 0.450 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.450 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.449 | |
| 1het | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.449 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.449 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.449 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.449 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.449 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.449 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.449 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.449 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.449 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.449 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.448 | |
| 1kqb | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.448 | |
| 1mok | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.448 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.448 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.448 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.448 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.448 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.448 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.448 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.448 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.448 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.448 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1g5q | ASP_SER_TYR_THR_CYS | Epidermin decarboxylase | 4.1.1 | 0.447 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.447 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.447 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.447 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.447 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.447 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.446 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.446 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.446 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.446 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.446 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.446 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.446 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.446 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.446 | |
| 1n06 | ADP | Riboflavin kinase | 2.7.1.26 | 0.445 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.445 | |
| 3a6q | FMN | FMN-binding protein | / | 0.445 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.445 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.445 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.445 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.445 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.444 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.444 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.444 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.444 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.444 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.444 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.444 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.444 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.444 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.443 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.443 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.443 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.443 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.443 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.443 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.443 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.443 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.443 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.443 | |
| 4o8a | FAD | Bifunctional protein PutA | 1.2.1.88 | 0.443 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.442 | |
| 1ds7 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.442 | |
| 2gmj | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.442 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.442 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3u9e | COA | Lmo1369 protein | / | 0.442 | |
| 3up0 | D7S | aceDAF-12 | / | 0.442 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.442 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.442 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.442 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1flm | FMN | FMN-binding protein | / | 0.441 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.441 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.441 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 3a3g | DLZ | Lumazine protein | / | 0.441 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.441 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.441 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.441 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1lke | DOG | Bilin-binding protein | / | 0.440 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.440 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.440 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.440 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.440 | |
| 3a6r | FMN | FMN-binding protein | / | 0.440 | |
| 3eks | CY9 | Actin-5C | / | 0.440 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.440 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.440 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.440 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.440 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.440 |