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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1dr3TAPDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1dr3TAPDihydrofolate reductase1.5.1.31.000
1dr2TAPDihydrofolate reductase1.5.1.30.802
1dr5NAPDihydrofolate reductase1.5.1.30.732
8dfrNDPDihydrofolate reductase1.5.1.30.654
2w3bNDPDihydrofolate reductase1.5.1.30.627
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.604
3nxxNDPDihydrofolate reductase1.5.1.30.579
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.566
3qlsNDPDihydrofolate reductase1.5.1.30.556
2cig1DGDihydrofolate reductase1.5.1.30.554
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.554
3d84NDPDihydrofolate reductase1.5.1.30.549
1dg8NDPDihydrofolate reductase1.5.1.30.548
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.548
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.546
1ia1NDPDihydrofolate reductase1.5.1.30.544
4m6jNDPDihydrofolate reductase1.5.1.30.539
5eccNAPDehydrofolate reductase type I/0.537
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.536
3tqaNDPDihydrofolate reductase/0.536
4kl9NDPDihydrofolate reductase1.5.1.30.535
1m78NDPDihydrofolate reductase1.5.1.30.532
1ai9NDPDihydrofolate reductase1.5.1.30.529
1rx1NAPDihydrofolate reductase1.5.1.30.529
3qlrNDPDihydrofolate reductase1.5.1.30.528
1drhNAPDihydrofolate reductase1.5.1.30.526
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.523
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.513
1u71MXADihydrofolate reductase1.5.1.30.496
1ma0NADAlcohol dehydrogenase class-31.1.1.10.490
1bim0QBRenin3.4.23.150.488
2g1o2IGRenin3.4.23.150.486
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.485
2w9hTOPDihydrofolate reductase1.5.1.30.482
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.481
3hl0NADMaleylacetate reductase/0.477
2g247IGRenin3.4.23.150.469
4ambDUDPutative glycosyl transferase/0.464
1lf3EH5Plasmepsin-23.4.23.390.463
1tehNADAlcohol dehydrogenase class-31.1.1.10.463
3b6zCO7Enoyl reductase LovC10.463
3vsxR32Renin3.4.23.150.463
1f8fNADBenzyl alcohol dehydrogenase/0.462
1ia4TQ6Dihydrofolate reductase1.5.1.30.462
3vyeVYERenin3.4.23.150.462
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.460
2v13C40Renin3.4.23.150.459
1s3uTQDDihydrofolate reductase1.5.1.30.457
2g1s4IGRenin3.4.23.150.457
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3gqvNAPEnoyl reductase LovC10.455
1ia3TQ5Dihydrofolate reductase1.5.1.30.454
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.453
2ikuLIYRenin3.4.23.150.452
3vswR31Renin3.4.23.150.452
2givACOHistone acetyltransferase KAT8/0.450
2nq8ZIDEnoyl-ACP reductase/0.450
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.449
1pd9CO4Dihydrofolate reductase1.5.1.30.448
1t2cNAIL-lactate dehydrogenase1.1.1.270.448
1tqf32PBeta-secretase 13.4.23.460.448
3own3OXRenin3.4.23.150.447
4m83ERYOleandomycin glycosyltransferase2.4.10.447
1osvCHCBile acid receptor/0.445
2g1r3IGRenin3.4.23.150.445
2i4qUA4Renin3.4.23.150.445
2xw7NDPDihydrofolate reductase/0.445
1drfFOLDihydrofolate reductase1.5.1.30.444
1kp3ATPArgininosuccinate synthase6.3.4.50.444
1lbcCYZGlutamate receptor 2/0.444
2gjlFMNNitronate monooxygenase1.13.12.160.444
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1xddAAYIntegrin alpha-L/0.443
2c20NADUDP-glucose 4-epimerase/0.443
2iko7IGRenin3.4.23.150.443
3b70NAPEnoyl reductase LovC10.443
4q71FADBifunctional protein PutA/0.443
3oqfS51Renin3.4.23.150.442
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.442
1mjaCOAHistone acetyltransferase ESA1/0.441
4l0qNADAlcohol dehydrogenase class-3/0.441
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
3lpkZ76Beta-secretase 13.4.23.460.440
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.440
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.440