sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 4qjc | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.551 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.540 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3cse | N22 | Uncharacterized protein | / | 0.474 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 3eek | 53S | Uncharacterized protein | / | 0.448 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 |