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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1diuBDMDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1diuBDMDihydrofolate reductase1.5.1.31.000
1disBDMDihydrofolate reductase1.5.1.30.706
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.501
1jolFFODihydrofolate reductase1.5.1.30.485
1draMTXDihydrofolate reductase1.5.1.30.480
4elb34SDihydrofolate reductase/0.479
4ele31IDihydrofolate reductase/0.478
1drbMTXDihydrofolate reductase1.5.1.30.477
4elb34RDihydrofolate reductase/0.474
4dfrMTXDihydrofolate reductase1.5.1.30.470
1rb3MTXDihydrofolate reductase1.5.1.30.468
1dhjMTXDihydrofolate reductase1.5.1.30.466
3eigMTXDihydrofolate reductase1.5.1.30.463
4elh53IDihydrofolate reductase/0.463
3fl8RARDihydrofolate reductase/0.462
1bzfTMQDihydrofolate reductase1.5.1.30.461
3och2MXDihydrofolate reductase1.5.1.30.460
4cd2FOLDihydrofolate reductase1.5.1.30.459
2drcMTXDihydrofolate reductase1.5.1.30.457
2dhfDZFDihydrofolate reductase1.5.1.30.454
1tdrMTXDihydrofolate reductase1.5.1.30.453
4elf35IDihydrofolate reductase/0.452
1ddsMTXDihydrofolate reductase1.5.1.30.447
3dfrMTXDihydrofolate reductase1.5.1.30.446
4elg52JDihydrofolate reductase/0.445
2hm9TRRDihydrofolate reductase1.5.1.30.440
5hi6MTXDihydrofolate reductase/0.440