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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1dhrNADDihydropteridine reductase1.5.1.34

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1dhrNADDihydropteridine reductase1.5.1.341.000
1dirNADDihydropteridine reductase1.5.1.340.610
1hdrNADDihydropteridine reductase1.5.1.340.582
3orfNADDihydropteridine reductase1.5.1.340.532
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.478
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.477
2dteNAIGlucose 1-dehydrogenase related protein/0.474
3lqfNADGalactitol dehydrogenase/0.473
4nbwNADShort-chain dehydrogenase/reductase SDR/0.473
3ig6438Urokinase-type plasminogen activator3.4.21.730.472
1k6cMK1Gag-Pol polyprotein3.4.23.160.469
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.468
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
4qecNAPElxO/0.465
1k6tXN1Gag-Pol polyprotein3.4.23.160.464
1lbcCYZGlutamate receptor 2/0.464
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.463
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.463
4k6fNAPPutative Acetoacetyl-CoA reductase/0.462
3ruaNADUDP-N-acetylglucosamine 4-epimerase/0.461
4dbzNDPPutative ketoacyl reductase1.3.10.461
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.460
3oqkS52Renin3.4.23.150.459
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.458
1bwsNDPGDP-L-fucose synthase/0.457
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
2c29NAPDihydroflavonol 4-reductase/0.454
4g7gVFVLanosterol 14-alpha-demethylase/0.453
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.452
2ikuLIYRenin3.4.23.150.451
1g6kNADGlucose 1-dehydrogenase1.1.1.470.450
1gqtACPRibokinase/0.450
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.449
4dc0NDPPutative ketoacyl reductase1.3.10.449
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.447
3mk6ACOPantothenate kinase 32.7.1.330.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.446
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.446
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.445
3b6zCO7Enoyl reductase LovC10.445
4r21STRCytochrome P450 family 17 polypeptide 2/0.444
4yryFADGlutamate synthase, beta subunit/0.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1xe55FEPlasmepsin-23.4.23.390.443
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
4uymVOR14-alpha sterol demethylase Cyp51B/0.443
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
5jlaNADPutative short-chain dehydrogenase/reductase/0.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1xddAAYIntegrin alpha-L/0.441
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.441
1tehNADAlcohol dehydrogenase class-31.1.1.10.440
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.440
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440