sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.653 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.621 | |
| 3eel | 53T | Uncharacterized protein | / | 0.613 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.600 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.593 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.592 | |
| 3cse | N22 | Uncharacterized protein | / | 0.590 | |
| 3qly | 55V | Uncharacterized protein | / | 0.589 | |
| 3eej | 53R | Uncharacterized protein | / | 0.588 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.581 | |
| 3eem | 53V | Uncharacterized protein | / | 0.579 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.575 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.574 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.569 | |
| 3eek | 53S | Uncharacterized protein | / | 0.568 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.568 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.561 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.561 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.558 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.554 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.553 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.543 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.536 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.526 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.525 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.516 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.510 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.507 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.505 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.504 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.500 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.499 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.499 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.497 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.493 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.490 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.485 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.482 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.481 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.479 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.478 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.477 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.476 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.475 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.474 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.473 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.473 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.472 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.470 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.470 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.470 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.469 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.469 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.469 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.468 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.465 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.465 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.465 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1err | RAL | Estrogen receptor | / | 0.464 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.464 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.464 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.463 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.462 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3h1j | SMA | Cytochrome b | / | 0.462 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.462 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3rg9 | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.461 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.460 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.460 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.459 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.458 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.458 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.458 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.458 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.457 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.457 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.457 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 2p15 | EZT | Estrogen receptor | / | 0.456 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.456 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.456 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.456 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.456 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.455 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.455 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.454 | |
| 2xvw | 9NR | Serum albumin | / | 0.454 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.454 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.454 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.453 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.453 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.453 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.453 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.453 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.453 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4xwt | U5P | Ribonuclease J | / | 0.453 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.452 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.452 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3v49 | PK0 | Androgen receptor | / | 0.452 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.451 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.451 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.451 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.451 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.451 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.451 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.450 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.450 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.449 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.448 | |
| 2xvv | 9DN | Serum albumin | / | 0.448 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.448 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 4l9k | EHF | Serum albumin | / | 0.448 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.448 | |
| 1pp9 | SMA | Cytochrome b | / | 0.447 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.447 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.446 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.446 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.446 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.446 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.445 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.445 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.445 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.445 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.445 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.445 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.445 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.445 | |
| 4l8u | 9AZ | Serum albumin | / | 0.445 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.444 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.444 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.444 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.444 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.444 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.444 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.444 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.443 | |
| 1sqv | UHD | Cytochrome b | / | 0.443 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.443 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.443 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.443 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.443 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.443 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.443 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.442 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 4mfb | 29T | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3dmj | GWE | Pol protein | / | 0.441 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.441 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.441 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.441 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.441 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.441 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.440 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.440 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.440 | |
| 3lu8 | IQX | Serum albumin | / | 0.440 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.440 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.440 |