sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 1.000 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.505 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.504 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.503 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.500 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.497 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.496 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.496 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.493 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.493 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.492 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.490 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.490 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.489 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.488 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.487 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.487 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.487 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.487 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.486 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.486 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.483 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.483 | |
| 2dxw | SAH | Diphthine synthase | / | 0.482 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.481 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.481 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.481 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.480 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.480 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.480 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.480 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.480 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.479 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.479 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.479 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.479 | |
| 3zhy | FM6 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.479 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.478 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.478 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.478 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.477 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.476 | |
| 3a3g | DLZ | Lumazine protein | / | 0.476 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.475 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.475 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.475 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.475 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.475 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.475 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.474 | |
| 2b4r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.474 | |
| 2dxv | SAH | Diphthine synthase | / | 0.474 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.473 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.473 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.473 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.473 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.473 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.472 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.472 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.472 | |
| 2ejz | SAH | Diphthine synthase | / | 0.472 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.472 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.472 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.472 | |
| 2pj4 | 414 | Carboxypeptidase B | / | 0.472 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.472 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.471 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.471 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.471 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.471 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.471 | |
| 1o6z | NAD | Malate dehydrogenase | / | 0.470 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.470 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.470 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.470 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.469 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 2e8s | SAH | Diphthine synthase | / | 0.468 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.468 | |
| 4xr9 | NAD | CalS8 | / | 0.468 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.468 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.467 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.467 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.467 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.467 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.467 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.467 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.467 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.467 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.467 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.467 | |
| 4jic | FMN | GTN Reductase | / | 0.467 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.466 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.466 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.466 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.466 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.466 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.466 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.466 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.466 | |
| 2cvu | CDP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.465 | |
| 2emr | SAH | Diphthine synthase | / | 0.465 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.465 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.465 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.465 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.465 | |
| 4hs4 | FMN | Chromate reductase | / | 0.465 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.465 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.464 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.464 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.464 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.464 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.463 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.463 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.463 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.463 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.463 | |
| 4frs | 0V6 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.463 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.462 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.462 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.462 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.462 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.462 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.462 | |
| 3x2e | NAI | Adenosylhomocysteinase | / | 0.462 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.462 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.462 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.462 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.462 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.462 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.462 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.462 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.461 | |
| 1xz8 | 5GP | Bifunctional protein PyrR | 2.4.2.9 | 0.461 | |
| 2g9r | G27 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.461 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.461 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.461 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.461 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.461 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.461 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.460 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.460 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.460 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.460 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.460 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.460 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.460 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.460 | |
| 2nr4 | FMN | Conserved protein | / | 0.460 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.460 | |
| 3rba | COD | Phosphopantetheine adenylyltransferase | / | 0.460 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.460 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.460 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.460 | |
| 1b5d | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.459 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.459 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.459 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.459 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.459 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2emu | SAH | Diphthine synthase | / | 0.459 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.459 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.459 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.459 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.459 | |
| 2zja | ACP | ATP-dependent DNA helicase Hel308 | / | 0.459 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.459 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.459 | |
| 3v2u | ATP | Protein GAL3 | / | 0.459 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.459 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.459 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.459 | |
| 5cfl | C2E | Stimulator of interferon genes protein | / | 0.459 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.459 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.458 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.458 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.458 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3s2v | 3HU | Glutamate receptor ionotropic, kainate 1 | / | 0.458 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.458 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.458 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.458 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.458 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.458 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.458 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.458 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.458 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.458 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.457 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.457 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.457 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.457 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.457 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.457 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.457 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 5a3b | APR | SIR2 family protein | / | 0.457 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.456 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 1ywg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.456 | |
| 2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.456 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.456 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.456 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.456 | |
| 1aa6 | MGD | Formate dehydrogenase H | 1.1.99.33 | 0.455 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.455 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.455 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.455 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.455 | |
| 2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.455 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.455 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.455 | |
| 3eks | CY9 | Actin-5C | / | 0.455 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.455 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.455 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.455 | |
| 3rqh | B6P | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.455 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.455 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.455 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.455 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.455 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.455 | |
| 4i9h | 1E4 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.455 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.454 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.454 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.454 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.454 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.454 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.454 | |
| 2egl | SAH | Diphthine synthase | / | 0.454 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.454 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.454 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.454 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.454 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.454 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.454 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.453 | |
| 1l8a | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.453 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.453 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.453 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.453 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.453 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.453 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1mbb | EEB | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.452 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.452 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.452 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.452 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.452 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.452 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.452 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.452 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.452 | |
| 3ftx | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.452 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.452 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.452 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.452 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.452 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.452 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.452 | |
| 4lxm | 1YU | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.452 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.452 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.452 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.451 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.451 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.451 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.451 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.451 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.451 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.451 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.451 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.451 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3rq8 | AP5 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.451 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.451 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.451 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.451 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.451 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.450 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.450 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.450 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.450 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.450 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.450 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.450 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.450 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.450 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.450 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.450 | |
| 4l5a | TBN | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.450 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 1kfc | IPL | Tryptophan synthase alpha chain | / | 0.449 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1ppl | 1Z7 | Penicillopepsin-1 | 3.4.23.20 | 0.449 | |
| 1tys | DHF | Thymidylate synthase | / | 0.449 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.449 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.449 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.449 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.449 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.449 | |
| 2qs1 | UB1 | Glutamate receptor ionotropic, kainate 1 | / | 0.449 | |
| 2vuu | NAP | Nitrogen metabolite repression protein nmrA | / | 0.449 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.449 | |
| 2zju | IM4 | Acetylcholine-binding protein | / | 0.449 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.449 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.449 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.449 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.449 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.449 | |
| 3u9e | COA | Lmo1369 protein | / | 0.449 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.449 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4h6p | FMN | Chromate reductase | / | 0.449 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.449 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.448 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 1z48 | FMN | NADPH dehydrogenase | / | 0.448 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.448 | |
| 2p6k | SAH | Diphthine synthase | / | 0.448 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.448 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.448 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.448 | |
| 3pll | F06 | Endothiapepsin | 3.4.23.22 | 0.448 | |
| 3rqq | BA3 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.448 | |
| 3vp6 | HLD | Glutamate decarboxylase 1 | 4.1.1.15 | 0.448 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.448 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.448 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1g5q | ASP_SER_TYR_THR_CYS | Epidermin decarboxylase | 4.1.1 | 0.447 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.447 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.447 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.447 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.447 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.447 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.447 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.447 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.447 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.447 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.447 | |
| 4z0h | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic | 1.2.1.12 | 0.447 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.446 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.446 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.446 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.446 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.446 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.446 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.446 | |
| 2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2eka | SAH | Diphthine synthase | / | 0.446 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.446 | |
| 2p6d | SAH | Diphthine synthase | / | 0.446 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.446 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.446 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.446 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 3r95 | ACO | MccE protein | / | 0.446 | |
| 3w2l | VRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.446 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.446 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4qec | NAP | ElxO | / | 0.446 | |
| 2dsg | SAH | Diphthine synthase | / | 0.445 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.445 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.445 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.445 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.445 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.445 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.445 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.445 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.445 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.445 | |
| 5ftf | ADP | TPR domain protein | / | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.444 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.444 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.444 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.444 | |
| 2ej2 | PPE | Branched-chain amino acid aminotransferase (IlvE) | / | 0.444 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.444 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.444 | |
| 3a3b | RBF | Lumazine protein | / | 0.444 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.444 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.444 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.444 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.444 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.444 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.444 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.444 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1e1q | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 1e1q | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.443 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 | 0.443 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.443 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.443 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.443 | |
| 2egs | SAH | Diphthine synthase | / | 0.443 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.443 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.443 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2ql6 | ADP | Nicotinamide riboside kinase 1 | / | 0.443 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.443 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.443 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.443 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.443 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.443 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.443 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.443 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.443 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.443 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.443 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.443 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 1gre | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.442 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.442 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.442 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2e16 | SAH | Diphthine synthase | / | 0.442 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.442 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.442 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.442 | |
| 2ohv | NHL | Glutamate racemase | / | 0.442 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.442 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3bt9 | DEQ | HTH-type transcriptional regulator QacR | / | 0.442 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.442 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.442 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.442 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.442 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.442 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.442 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.442 | |
| 3x21 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.442 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.442 | |
| 4ddy | DN6 | Beta-lactamase | / | 0.442 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4xcz | FON | Qdtf | / | 0.442 | |
| 1b3r | NAD | Adenosylhomocysteinase | 3.3.1.1 | 0.441 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1i5e | U5P | Uracil phosphoribosyltransferase | / | 0.441 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.441 | |
| 2cwf | NDP | Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase | / | 0.441 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.441 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.441 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.441 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.441 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.441 | |
| 2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.441 | |
| 2pcm | SAH | Diphthine synthase | / | 0.441 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.441 | |
| 2trs | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.441 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.441 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.441 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.441 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.441 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.441 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.441 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.441 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.441 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.441 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.441 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4zrn | UPG | UDP-glucose 4-epimerase, putative | / | 0.441 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.440 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.440 | |
| 1qpl | 587 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.440 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.440 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.440 | |
| 3d28 | B34 | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.440 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.440 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.440 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.440 | |
| 4dja | FAD | (6-4) photolyase | / | 0.440 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4gid | 0GH | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.440 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.440 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.440 |