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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1cxzGSPTransforming protein RhoA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1cxzGSPTransforming protein RhoA/1.000
1kmqGNPTransforming protein RhoA/0.626
2gcpGSPRho-related GTP-binding protein RhoC/0.616
3a58GNPGTP-binding protein RHO1/0.605
1m7bGTPRho-related GTP-binding protein RhoE/0.602
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.590
1a2bGSPTransforming protein RhoA/0.584
3kz1GSPTransforming protein RhoA/0.582
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.581
4xoiGTPTransforming protein RhoA/0.576
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.574
3th5GNPRas-related C3 botulinum toxin substrate 1/0.552
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.551
1g17GNPRas-related protein SEC4/0.549
1yzqGNPRas-related protein Rab-6A/0.549
3eg5GNPCell division control protein 42 homolog/0.549
1s1cGNPTransforming protein RhoA/0.548
1gwnGTPRho-related GTP-binding protein RhoE/0.543
4js0GNPCell division control protein 42 homolog/0.539
1zc3GNPRas-related protein Ral-A/0.536
3bbpGTPRas-related protein Rab-6A/0.536
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.533
2gilGTPRas-related protein Rab-6A/0.533
4kvgGTPRas-related protein Rap-1A/0.531
1t91GTPRas-related protein Rab-7a/0.530
3lbnGNPGTPase HRas/0.530
1xtrGNPGTP-binding protein Rheb/0.529
1yhnGTPRas-related protein Rab-7a/0.529
5hpyGDPTransforming protein RhoA/0.528
4nyiGNPGTPase HRas/0.527
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.526
1z2cGNPRho-related GTP-binding protein RhoC/0.525
4mitGTPRho-related protein racC/0.525
1zc4GNPRas-related protein Ral-A/0.524
4g0nGNPGTPase HRas/0.524
3e5hGNPRas-related protein Rab-28/0.523
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.518
1zbdGTPRas-related protein Rab-3A/0.517
1e96GTPRas-related C3 botulinum toxin substrate 1/0.516
3ddcGNPGTPase HRas/0.516
4lhwGNPRas-related protein Rab-8A/0.514
4nyjGNPGTPase HRas/0.510
1xtsGTPGTP-binding protein Rheb/0.509
3oesGNPGTPase RhebL1/0.509
2ffqGSPRas-related protein Rab-6B/0.507
3oiuGNPGTPase HRas/0.507
2c5lGTPGTPase HRas/0.504
4dsnGCPGTPase KRas/0.504
3i3sGNPGTPase HRas/0.502
3nbzGTPGTP-binding nuclear protein Ran/0.502
3tgpGNPGTPase HRas/0.499
3v4fGNPGTPase HRas/0.499
4dltGNPGTPase HRas/0.499
3oivGNPGTPase HRas/0.497
3w3zGTPGTP-binding nuclear protein Ran/0.497
4k81GTPGTPase HRas/0.497
2zetGTPRas-related protein Rab-27B/0.494
3rabGNPRas-related protein Rab-3A/0.491
3a6pGTPGTP-binding nuclear protein Ran/0.490
3tklGTPRas-related protein Rab-1A/0.490
2rgeGNPGTPase HRas/0.489
3tnfGNPRas-related protein Rab-8A/0.489
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.488
2clsGTPRho-related GTP-binding protein Rho6/0.487
4ol0GTPGTP-binding nuclear protein Ran/0.487
5dhaGNPGTP-binding nuclear protein Ran/0.487
3lawGNPRas-related protein Rab-7a/0.486
3pitGNPRas-related protein M-Ras/0.486
3lbhGNPGTPase HRas/0.485
3rs7GNPGTPase HRas/0.484
3kucGDPRas-related protein Rap-1A/0.482
5b2zGNPGTPase HRas/0.480
1vg8GNPRas-related protein Rab-7a/0.478
2rggGNPGTPase HRas/0.478
5jljGNPGTP-binding nuclear protein Ran/0.478
2rgcGNPGTPase HRas/0.477
3l8yGNPGTPase HRas/0.477
4cymGCPRas-related protein Rab-32/0.477
3k8yGNPGTPase HRas/0.475
4hdoGNPRas-related protein Rap-1b/0.474
3lbiGNPGTPase HRas/0.472
3kkoGNPRas-related protein M-Ras/0.470
1lfdGNPGTPase HRas/0.469
4rkfGNPRas-related protein Rab-3/0.469
2bkuGTPGTP-binding nuclear protein Ran/0.468
4dvgGSPRho family GTPase/0.468
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.468
3rs5GNPGTPase HRas/0.463
1z0aGDPRas-related protein Rab-2A/0.462
2msdGNPMHC class I alpha chain/0.462
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.458
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.458
4qxaGTPRas-related protein Rab-9A/0.456
4dlwGNPGTPase HRas/0.455
2cl6CAGGTPase HRas/0.454
3oiwGNPGTPase HRas/0.453
4dsoGSPGTPase KRas/0.453
3rs4GNPGTPase HRas/0.452
2rgbGNPGTPase HRas/0.451
4o25GTPGTP-binding protein Rheb/0.449
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.448
4xvrGNPGTPase HRas/0.448
2fe4GDPRas-related protein Rab-6B/0.447
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.447
3cphGDPRas-related protein SEC4/0.447
3kudGDPGTPase HRas/0.446
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.443
3qbtGNPRas-related protein Rab-8A/0.442
4dlxGNPGTPase HRas/0.441