scPDB - Distribution of Binding site Similarity values of 1cd2 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1cd2	FOL	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	1.000
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.674
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.639
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.615
3qlx	QLR	Uncharacterized protein	/	0.602
3cse	N22	Uncharacterized protein	/	0.585
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.573
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.572
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.569
3qly	55V	Uncharacterized protein	/	0.569
4h98	14Q	Uncharacterized protein	/	0.567
3eej	53R	Uncharacterized protein	/	0.566
3eek	53S	Uncharacterized protein	/	0.566
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.565
3eel	53T	Uncharacterized protein	/	0.562
3eem	53V	Uncharacterized protein	/	0.555
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.552
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.549
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.547
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.547
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.542
3qlz	QLZ	Uncharacterized protein	/	0.531
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.524
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.517
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.514
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.512
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.509
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.509
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.506
3ia4	MTX	Dihydrofolate reductase	/	0.503
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.501
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.499
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.499
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.499
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.498
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.497
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.497
2w3v	TOP	Dihydrofolate reductase	/	0.493
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.493
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.493
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.492
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.490
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.489
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.488
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.487
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.486
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.486
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.485
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.485
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.484
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.483
3jwc	EKB	Dihydrofolate reductase	/	0.483
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.482
2zza	FOL	Dihydrofolate reductase	/	0.481
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.480
3tqb	FOL	Dihydrofolate reductase	/	0.477
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.474
3tq9	MTX	Dihydrofolate reductase	/	0.473
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.473
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.472
4elb	34S	Dihydrofolate reductase	/	0.471
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.470
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.468
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.467
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.467
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.467
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.465
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.464
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.464
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.464
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.463
3sa1	6DR	Dihydrofolate reductase	/	0.463
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.462
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.462
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.462
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.460
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.460
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.459
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.459
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.458
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.458
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
4ele	31I	Dihydrofolate reductase	/	0.457
1kzj	CB3	Thymidylate synthase	/	0.456
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
2w3w	VG9	Dihydrofolate reductase	/	0.454
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.454
3vt9	YI4	Vitamin D3 receptor	/	0.453
3sai	9DR	Dihydrofolate reductase	/	0.452
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.452
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.451
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.450
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.449
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.449
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.449
3sa2	7DR	Dihydrofolate reductase	/	0.449
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.449
3aba	FLI	Cytochrome P450	/	0.448
3ezp	B3N	Histone deacetylase 8	3.5.1.98	0.448
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.448
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.447
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.447
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.446
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.446
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
3fl8	RAR	Dihydrofolate reductase	/	0.445
3jwm	5WB	Dihydrofolate reductase	/	0.444
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.443
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.443
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.443
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.442
4elg	52J	Dihydrofolate reductase	/	0.442
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
1rg7	MTX	Dihydrofolate reductase	1.5.1.3	0.440
7dfr	FOL	Dihydrofolate reductase	1.5.1.3	0.440