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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1c9wNAPAldose reductase-related protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1c9wNAPAldose reductase-related protein 2/1.000
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.527
1ah4NAPAldose reductase1.1.1.210.523
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.523
3qkzNAPAldose reductase-related protein 11.1.1.210.521
3h7rNAPAldo-keto reductase family 4 member C8/0.508
1x96NAPAldose reductase1.1.1.210.504
3q65NAPAldose reductase1.1.1.210.504
4pmjNAPPutative oxidoreductase/0.503
2j8tNAPAldose reductase1.1.1.210.502
1z8aNAPAldose reductase1.1.1.210.499
2iq0NAPAldose reductase1.1.1.210.498
2acqNAPAldose reductase1.1.1.210.497
2pf8NDPAldose reductase1.1.1.210.497
4jtqNAPAldo-keto reductase family 1 member C2/0.497
1adsNAPAldose reductase1.1.1.210.493
2pevNDPAldose reductase1.1.1.210.493
1x98NAPAldose reductase1.1.1.210.490
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.487
1az2NAPAldose reductase1.1.1.210.486
2hdjNDPAldo-keto reductase family 1 member C2/0.485
4dz5NAPAldo-keto reductase family 1 member C3/0.481
3v36NAPAldose reductase1.1.1.210.480
4xo7NAPAldo-keto reductase family 1 member C2/0.479
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.477
3q67NAPAldose reductase1.1.1.210.476
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.475
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.474
2hejNDPAldo-keto reductase family 1 member C211.1.10.473
4g5dNDPProstaglandin F synthase1.1.1.1880.473
4jq3NAPAldo-keto reductase family 1 member C2/0.473
1s1rNAPAldo-keto reductase family 1 member C3/0.472
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.472
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.463
2acsNAPAldose reductase1.1.1.210.463
3o3rNAPAldose reductase-related protein 11.1.1.210.461
4l1xNAPAldo-keto reductase family 1 member C2/0.456
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.455
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.441
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.441