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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1c1uBAIProthrombin3.4.21.5

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1c1uBAIProthrombin3.4.21.51.000
1ghv120Prothrombin3.4.21.50.650
1afeALZProthrombin3.4.21.50.619
2zhw12UProthrombin3.4.21.50.619
1ae8AZLProthrombin3.4.21.50.616
2pksG44Prothrombin3.4.21.50.615
1ypmRA4Prothrombin3.4.21.50.607
1ypjUIBProthrombin3.4.21.50.603
1c4vIH2Prothrombin3.4.21.50.600
1c1wBAHProthrombin3.4.21.50.597
1nm6L86Prothrombin3.4.21.50.593
1zgi382Prothrombin3.4.21.50.591
4loy6XSProthrombin3.4.21.50.587
2zfp19UProthrombin3.4.21.50.585
1gj5130Prothrombin3.4.21.50.584
2jh5895Prothrombin3.4.21.50.583
2jh6894Prothrombin3.4.21.50.580
2zhq27UProthrombin3.4.21.50.580
2v3oI26Prothrombin3.4.21.50.579
3c1kT15Prothrombin3.4.21.50.575
2zgx29UProthrombin3.4.21.50.572
2r2mI50Prothrombin3.4.21.50.569
1d3dBZTProthrombin3.4.21.50.567
4lxb7R9Prothrombin3.4.21.50.566
1sb1165Prothrombin3.4.21.50.565
2zhf49UProthrombin3.4.21.50.565
2zda32UProthrombin3.4.21.50.562
1d6w00RProthrombin3.4.21.50.561
1ypgUIRProthrombin3.4.21.50.559
2anmCDOProthrombin3.4.21.50.558
1c4uIH1Prothrombin3.4.21.50.557
2gdeSN3Prothrombin3.4.21.50.557
1ny2ARG_PRO_PRO_GLYProthrombin3.4.21.50.555
2zff53UProthrombin3.4.21.50.555
2v3hI25Prothrombin3.4.21.50.554
1mu8CDBProthrombin3.4.21.50.552
2zg050UProthrombin3.4.21.50.552
3qwc98PProthrombin3.4.21.50.552
2zdv37UProthrombin3.4.21.50.550
1d3pBT3Prothrombin3.4.21.50.549
1d9i00PProthrombin3.4.21.50.549
2cn0F25Prothrombin3.4.21.50.548
1o0d163Prothrombin3.4.21.50.543
2zgb21UProthrombin3.4.21.50.543
3eq02TSProthrombin3.4.21.50.543
1ta6177Prothrombin3.4.21.50.542
2zi224UProthrombin3.4.21.50.542
1d4pBPPProthrombin3.4.21.50.541
1zgv501Prothrombin3.4.21.50.541
3f6891UProthrombin3.4.21.50.541
1k22MELProthrombin3.4.21.50.539
2jh0701Prothrombin3.4.21.50.539
1ypeUIPProthrombin3.4.21.50.538
3egkM18Prothrombin3.4.21.50.537
1ypkCCRProthrombin3.4.21.50.536
2bdyUNBProthrombin3.4.21.50.535
1mueCDDProthrombin3.4.21.50.534
2zc922UProthrombin3.4.21.50.534
4ax9N5NProthrombin3.4.21.50.534
1t4v14AProthrombin3.4.21.50.532
2bvs2CEProthrombin3.4.21.50.532
2znk31UProthrombin3.4.21.50.532
3dhk23UProthrombin3.4.21.50.532
4az29MUProthrombin3.4.21.50.532
2uuj896Prothrombin3.4.21.50.530
1yplRA8Prothrombin3.4.21.50.529
4hfp15UProthrombin3.4.21.50.529
1c5nESIProthrombin3.4.21.50.527
4bahMELProthrombin3.4.21.50.527
4n3l2FNProthrombin3.4.21.50.527
1oytFSNProthrombin3.4.21.50.522
1uvsI11Prothrombin3.4.21.50.522
2zhe13UProthrombin3.4.21.50.521
4e7r0NWProthrombin3.4.21.50.521
2zf051UProthrombin3.4.21.50.520
3biu10UProthrombin3.4.21.50.518
2zfq45UProthrombin3.4.21.50.516
2a2xNA9Prothrombin3.4.21.50.515
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.515
1xm1GAHProthrombin3.4.21.50.514
3dux64UProthrombin3.4.21.50.514
1gj4132Prothrombin3.4.21.50.512
1t4u81AProthrombin3.4.21.50.510
4bakM67Prothrombin3.4.21.50.510
1ta2176Prothrombin3.4.21.50.509
1vzqSHYProthrombin3.4.21.50.509
1k21IGNProthrombin3.4.21.50.508
2zfr46UProthrombin3.4.21.50.508
1zrb062Prothrombin3.4.21.50.507
2bxtC2DProthrombin3.4.21.50.505
3qto10PProthrombin3.4.21.50.505
4rn615UProthrombin3.4.21.50.505
1obnASVIsopenicillin N synthase1.21.3.10.504
1riwOSCProthrombin3.4.21.50.504
1z71L17Prothrombin3.4.21.50.504
2he5NDPAldo-keto reductase family 1 member C211.1.10.504
2ziq26UProthrombin3.4.21.50.503
1nzq162Prothrombin3.4.21.50.501
3biv11UProthrombin3.4.21.50.500
1owk303Urokinase-type plasminogen activator3.4.21.730.499
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.498
2uuk897Prothrombin3.4.21.50.497
1c4yIH3Prothrombin3.4.21.50.496
1wqvPSMCoagulation factor VII3.4.21.210.495
3p1799PProthrombin3.4.21.50.495
2cf9348Prothrombin3.4.21.50.494
4bamMM9Prothrombin3.4.21.50.494
4q93STLTyrosine--tRNA ligase, cytoplasmic6.1.1.10.494
1kqcFMNOxygen-insensitive NAD(P)H nitroreductase/0.490
3fp0FP015-O-acetyltransferase/0.490
4baoMVFProthrombin3.4.21.50.490
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.488
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.486
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.485
1w7gMIUProthrombin3.4.21.50.484
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.483
4ayv9MQProthrombin3.4.21.50.483
4m5pFMNNADPH dehydrogenase/0.483
1bk0ACVIsopenicillin N synthase1.21.3.10.480
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.480
2vbpVB1Isopenicillin N synthase1.21.3.10.480
3qtv06PProthrombin3.4.21.50.480
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.480
1bcuPRLProthrombin3.4.21.50.479
1kp2ATPArgininosuccinate synthase6.3.4.50.479
1rszDIHPurine nucleoside phosphorylase2.4.2.10.479
2zseACPPantothenate kinase2.7.1.330.479
4h3f10OBeta-secretase 13.4.23.460.479
3c27DKKProthrombin3.4.21.50.478
4banM6SProthrombin3.4.21.50.478
1ktsC24Prothrombin3.4.21.50.476
1x1bSAHC-20 methyltransferase/0.476
2rlcCHDCholoylglycine hydrolase3.5.1.240.476
2y3pSM8DNA gyrase subunit A/0.476
4dc0NDPPutative ketoacyl reductase1.3.10.476
1hb1OCVIsopenicillin N synthase1.21.3.10.475
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.475
2owuSAHDiphthine synthase/0.475
3ixp834Ecdysone receptor/0.475
1owe675Urokinase-type plasminogen activator3.4.21.730.474
3adaNADSubunit alpha of sarocosine oxidase/0.474
1p4aPCPPur operon repressor/0.473
2c4fGILCoagulation factor VII3.4.21.210.473
2fb35ADGTP 3',8-cyclase4.1.99.180.473
4xguADPPutative pachytene checkpoint protein 2/0.473
1mp0NADAlcohol dehydrogenase class-31.1.1.10.472
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.472
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.472
3iaaTYDCalG2/0.471
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.471
4bmpFMNProtein NrdI/0.471
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.470
3zkyWT4Isopenicillin N synthase1.21.3.10.470
2bu9HFVIsopenicillin N synthase1.21.3.10.469
2gv8NDPThiol-specific monooxygenase1.14.130.469
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.469
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.469
4bb3KKAIsopenicillin N synthase1.21.3.10.469
4dbzNDPPutative ketoacyl reductase1.3.10.469
1f92UKPUrokinase-type plasminogen activator3.4.21.730.468
1hb3SCVIsopenicillin N synthase1.21.3.10.468
1qiqACCIsopenicillin N synthase1.21.3.10.468
2iviACWIsopenicillin N synthase1.21.3.10.468
3pn1IVHDNA ligase/0.468
1g8oU5PN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.467
3af3GCPPantothenate kinase2.7.1.330.467
3v49PK0Androgen receptor/0.467
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.467
4f5yC2EStimulator of interferon genes protein/0.467
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.467
1ds7FMNOxygen-insensitive NAD(P)H nitroreductase/0.466
2e15SAHDiphthine synthase/0.466
2xbxRR8Coagulation factor X3.4.21.60.466
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.466
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.466
4baqM4ZProthrombin3.4.21.50.466
1oc1ASVIsopenicillin N synthase1.21.3.10.465
1rx1NAPDihydrofolate reductase1.5.1.30.465
2ejzSAHDiphthine synthase/0.465
4fuf8UPUrokinase-type plasminogen activator3.4.21.730.465
1ddsMTXDihydrofolate reductase1.5.1.30.464
1udaUFGUDP-glucose 4-epimerase5.1.3.20.464
1yb5NAPQuinone oxidoreductase1.6.5.50.464
2e07SAHDiphthine synthase/0.464
2eeqSAHDiphthine synthase/0.464
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2osbAP5Adenylate kinase/0.464
2vprTDCTetracycline repressor protein class H/0.464
2y60M8FIsopenicillin N synthase1.21.3.10.464
3clrFADElectron transfer flavoprotein subunit alpha/0.464
3v4aPK1Androgen receptor/0.464
4jl6ADPAdenylate kinase/0.464
1ddrMTXDihydrofolate reductase1.5.1.30.463
1tsxUMPThymidylate synthase/0.463
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.463
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.463
4fuj1U9Urokinase-type plasminogen activator3.4.21.730.463
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.463
1b2lNDCAlcohol dehydrogenase1.1.1.10.462
1qrrUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.462
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.462
2zshGA3Gibberellin receptor GID1A30.462
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.462
4fuiUI3Urokinase-type plasminogen activator3.4.21.730.462
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.462
4xqcNADHomospermidine synthase2.5.1.440.462
2vbdV10Isopenicillin N synthase1.21.3.10.461
3g1oRF1HTH-type transcriptional regulator EthR/0.461
3wv7ADPHmd co-occurring protein HcgE/0.461
4k81GTPGTPase HRas/0.461
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.461
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.460
2bjfDXCCholoylglycine hydrolase3.5.1.240.460
2jb4A14Isopenicillin N synthase1.21.3.10.460
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.460
4ef4C2EStimulator of interferon genes protein/0.460
4ho9UTPGlucose-1-phosphate thymidylyltransferase/0.460
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.459
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.459
2q3fGNPRas-related GTP-binding protein D/0.459
3cvkN34Genome polyprotein2.7.7.480.459
3d0bSNXHeat shock protein HSP 90-alpha/0.459
4du6GTPGTP cyclohydrolase 1/0.459
4ke11R6Beta-secretase 13.4.23.460.459
4pzrCOAHistone acetyltransferase p300/0.459
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.459
2qenADPWalker-Type ATPase/0.458
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.458
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
4b1rITCTetracycline repressor protein class D/0.458
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.458
1kqbFMNOxygen-insensitive NAD(P)H nitroreductase/0.457
1z95198Androgen receptor/0.457
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.457
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.457
3mjhGTPRas-related protein Rab-5A/0.457
3tp0FO5HTH-type transcriptional regulator EthR/0.457
3x2fNAIAdenosylhomocysteinase/0.457
4rww2BALmo2692 protein/0.457
4ycoFMNtRNA-dihydrouridine(16) synthase/0.457
5d3qGDPDynamin-13.6.5.50.457
4zj8SUVOrexin receptor type 1/0.457
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.456
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.456
2h55DZ8Heat shock protein HSP 90-alpha/0.456
2ifaFMNUncharacterized protein/0.456
2owkSAHDiphthine synthase/0.456
2x7hPFNProstaglandin reductase 310.456
2y6fM9FIsopenicillin N synthase1.21.3.10.456
4a81DXCMajor pollen allergen Bet v 1-A/0.456
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.456
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1wtg3BPCoagulation factor VII3.4.21.210.455
2vcmM11Isopenicillin N synthase1.21.3.10.455
3fr5I4AFatty acid-binding protein, adipocyte/0.455
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.455
3rbvNAPSugar 3-ketoreductase/0.455
3zeiAWHO-acetylserine sulfhydrylase/0.455
4cf7ADPAdenylate kinase/0.455
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4fue7UPUrokinase-type plasminogen activator3.4.21.730.455
6cp4CAMCamphor 5-monooxygenase1.14.15.10.455
1f20FADNitric oxide synthase, brain1.14.13.390.454
1pqc444Oxysterols receptor LXR-beta/0.454
1yu9GNPRas-related protein Rab-4A/0.454
2dshSAHDiphthine synthase/0.454
2rtqIMIStreptavidin/0.454
3af0GDPPantothenate kinase2.7.1.330.454
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.454
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.454
3od48XQHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.454
3sp9IL2Peroxisome proliferator-activated receptor delta/0.454
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.454
4twnB96Ephrin type-A receptor 32.7.10.10.454
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.454
5c3jUQ1Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.454
5c3jUQ1Succinate dehydrogenase cytochrome b560/0.454
1dhfFOLDihydrofolate reductase1.5.1.30.453
1g0rTHMGlucose-1-phosphate thymidylyltransferase/0.453
1me6IVSPlasmepsin-23.4.23.390.453
1muuGDXGDP-mannose 6-dehydrogenase1.1.1.1320.453
1qjfACSIsopenicillin N synthase1.21.3.10.453
1x1cSAHC-20 methyltransferase/0.453
2egbSAHDiphthine synthase/0.453
3b2sB2STrichothecene 3-O-acetyltransferase/0.453
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.453
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.453
4b2gV1NUncharacterized protein/0.453
4dptAGSMevalonate diphosphate decarboxylase/0.453
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.453
4xr9NADCalS8/0.453
3sn6P0GBeta-2 adrenergic receptor/0.453
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1v3sATPSignaling protein/0.452
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.452
2huqSAHDiphthine synthase/0.452
2ohq7IPBeta-secretase 13.4.23.460.452
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.452
2trsPLSTryptophan synthase beta chain4.2.1.200.452
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3w6hAZMCarbonic anhydrase 14.2.1.10.452
1cf3FADGlucose oxidase1.1.3.40.451
1j49NADD-lactate dehydrogenase1.1.1.280.451
1pq944BOxysterols receptor LXR-beta/0.451
1r2jFADFkbI/0.451
1vceSAHDiphthine synthase/0.451
1xj7DHTAndrogen receptor/0.451
2iyfERYOleandomycin glycosyltransferase2.4.10.451
2p3qSAHGenome polyprotein/0.451
2xtnGTPGTPase IMAP family member 2/0.451
3gduTYR_ARG_PHESerine endoprotease DegS3.4.21.1070.451
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.451
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.451
3jzdNADMaleylacetate reductase/0.451
4c6uTLG3-oxoacyl-ACP synthase/0.451
4dpy2P0Mevalonate diphosphate decarboxylase/0.451
4i1c1BEBeta-secretase 13.4.23.460.451
4okx198Androgen receptor/0.451
4yfy0FXVioF/0.451
1fm4DXCMajor pollen allergen Bet v 1-L/0.450
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1ma0NADAlcohol dehydrogenase class-31.1.1.10.450
1uzwCDHIsopenicillin N synthase1.21.3.10.450
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.450
2x06NADL-sulfolactate dehydrogenase/0.450
2zsiGA4Gibberellin receptor GID1A30.450
3ed1GA3Gibberellin receptor GID1/0.450
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.450
3lqfNADGalactitol dehydrogenase/0.450
4b4w9L9Bifunctional protein FolD/0.450
4f6w0SSCyclin-dependent kinase 82.7.11.220.450
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4tvbNADHomospermidine synthase2.5.1.440.450
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.450
4xq9NADHomospermidine synthase2.5.1.440.450
4yusFMNFamily 3 adenylate cyclase/0.450
1fdiMGDFormate dehydrogenase H1.1.99.330.449
1njfADPDNA polymerase III subunit tau2.7.7.70.449
2a9y26AAdenosine kinase2.7.1.200.449
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2piuDHTAndrogen receptor/0.449
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2z6rSAHDiphthine synthase/0.449
2zaxCAMCamphor 5-monooxygenase1.14.15.10.449
3utu1TSProthrombin3.4.21.50.449
3vqsJT1Genome polyprotein/0.449
3wtkTH4Acetylcholine-binding protein/0.449
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.449
4fub4UPUrokinase-type plasminogen activator3.4.21.730.449
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.448
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.448
1ozvSAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.448
2j4lUTPUridylate kinase2.7.4.220.448
2pckSAHDiphthine synthase/0.448
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.448
2y5hY5HCoagulation factor X3.4.21.60.448
3dds26BGlycogen phosphorylase, liver form2.4.1.10.448
3e8xNAPBH1520 protein/0.448
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
3s87ADPRibonucleoside-diphosphate reductase large chain 11.17.4.10.448
4bti7R9Coagulation factor X3.4.21.60.448
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.448
4qxaGTPRas-related protein Rab-9A/0.448
5e7oMGDDMSO reductase family type II enzyme, molybdopterin subunit/0.448
4mqt2CUMuscarinic acetylcholine receptor M2/0.448
1l5r700Glycogen phosphorylase, liver form2.4.1.10.447
1ri4SAMmRNA cap guanine-N7 methyltransferase2.1.1.560.447
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2gz7D3FOrf1a polyprotein/0.447
2r97FMNNAD(P)H dehydrogenase (quinone)/0.447
3a20FMNFMN-binding protein/0.447
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.447
3gqzGF7Beta-lactamase3.5.2.60.447
4k6fNAPPutative Acetoacetyl-CoA reductase/0.447
5cmx0G6Prothrombin3.4.21.50.447
5czySAMEukaryotic huntingtin interacting protein B/0.447
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.446
1icuFMNOxygen-insensitive NAD(P)H nitroreductase/0.446
1lnmDTXBilin-binding protein/0.446
1u3dFADCryptochrome-1/0.446
1uyiPUZHeat shock protein HSP 90-alpha/0.446
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.446
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3l5dBDVBeta-secretase 13.4.23.460.446
3n0hTOPDihydrofolate reductase1.5.1.30.446
3phiNDPShikimate dehydrogenase (NADP(+))/0.446
3qiyQI1Botulinum neurotoxin type A3.4.24.690.446
3uylTYDProbable NDP-rhamnosyltransferase/0.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4eb7PLPCysteine desulfurase IscS 2/0.446
4iraFAD4-hydroxyphenylacetate 3-monooxygenase/0.446
4oztP1AEcdysone receptor, putative/0.446
4xz3COAAcyl-CoA synthetase (NDP forming)/0.446
4ycpFMNtRNA-dihydrouridine(16) synthase/0.446
5cnsCDPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.446
5esdTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.446
1lf2R37Plasmepsin-23.4.23.390.445
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.445
1ooqFMNOxygen-insensitive NAD(P)H nitroreductase/0.445
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2fr1NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.445
2nnqT4BFatty acid-binding protein, adipocyte/0.445
3gwdNAPCyclohexanone monooxygenase/0.445
3iaeD7KBenzaldehyde lyase/0.445
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.445
3u2mFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.445
4dneDTBStreptavidin/0.445
4j7hTRHPCZA361.3/0.445
4loh1SYStimulator of interferon genes protein/0.445
4nu0AP5Adenylate kinase/0.445
5fm7ADPRuvB-like helicase/0.445
5iu86DZAdenosine receptor A2a/0.445
1fyfSSAThreonine--tRNA ligase6.1.1.30.444
1gveNAPAflatoxin B1 aldehyde reductase member 310.444
1hk2T44Serum albumin/0.444
1uxkNADMalate dehydrogenase/0.444
1y0s331Peroxisome proliferator-activated receptor delta/0.444
2bn4FMNNADPH--cytochrome P450 reductase/0.444
2cloPLSTryptophan synthase beta chain4.2.1.200.444
2emuSAHDiphthine synthase/0.444
2pcgSAHDiphthine synthase/0.444
2vivVG2Urokinase-type plasminogen activator3.4.21.730.444
2wi4ZZ4Heat shock protein HSP 90-alpha/0.444
2ym1FADPhenylacetone monooxygenase1.14.13.920.444
2zp0PI0Coagulation factor VII3.4.21.210.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3f03FMNPentaerythritol tetranitrate reductase/0.444
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.444
3vy2FMNFMN-binding protein/0.444
3zoiM2WIsopenicillin N synthase1.21.3.10.444
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.444
4cjeQ31Integrase/0.444
4ge5A89Tyrosine-protein phosphatase non-receptor type 93.1.3.480.444
4o671SYCyclic GMP-AMP synthase/0.444
4ocvANPAminoglycoside phosphotransferase/0.444
4oznATPAmmonium transporter/0.444
1f5fDHTSex hormone-binding globulin/0.443
1mvtDTMDihydrofolate reductase1.5.1.30.443
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.443
1rpnNDPGDP-mannose 4,6-dehydratase/0.443
1rzuADPGlycogen synthase 12.4.1.210.443
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.443
2p6lSAHDiphthine synthase/0.443
2v58LZJBiotin carboxylase6.3.4.140.443
2wgjVGHHepatocyte growth factor receptor2.7.10.10.443
2yimMC4Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.443
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.443
3d84NDPDihydrofolate reductase1.5.1.30.443
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.443
3n39FMNProtein NrdI/0.443
3s5wFADL-ornithine N(5)-monooxygenase/0.443
3wv9FEGHmd co-occurring protein HcgE/0.443
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
4u0oMTALipoyl synthase 2/0.443
1diuBDMDihydrofolate reductase1.5.1.30.442
1dr5NAPDihydrofolate reductase1.5.1.30.442
1eq2ADQADP-L-glycero-D-manno-heptose-6-epimerase/0.442
1jdzFMBPurine nucleoside phosphorylase/0.442
1owi426Urokinase-type plasminogen activator3.4.21.730.442
1pl2ABYGlutathione S-transferase A12.5.1.180.442
1u2yGOXPancreatic alpha-amylase/0.442
2d81RB3Poly(3-hydroxybutyrate) depolymerase/0.442
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.442
2vkeTACTetracycline repressor protein class D/0.442
2xvv9DNSerum albumin/0.442
2ykjYKJHeat shock protein HSP 90-alpha/0.442
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.442
3o0qADNVitamin B12-dependent ribonucleotide reductase/0.442
3o8hO8HHTH-type transcriptional regulator EthR/0.442
3qls55VDihydrofolate reductase1.5.1.30.442
3upi0C2Genome polyprotein2.7.7.480.442
3uwlFOZThymidylate synthase/0.442
4ead0NPThymidine phosphorylase2.4.2.40.442
4frkDWDBeta-secretase 13.4.23.460.442
4jc51K5Stimulator of interferon genes protein/0.442
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.442
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.442
5dw50T1Succinyl-CoA:acetate CoA-transferase/0.442
1blzACVIsopenicillin N synthase1.21.3.10.441
1eiiRTLRetinol-binding protein 2/0.441
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.441
1wliFMNFMN-binding protein/0.441
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.441
2eleSAHDiphthine synthase/0.441
2hekGDPUncharacterized protein/0.441
2v1aFMNNPH1-1/0.441
2z52H23Geranylgeranyl pyrophosphate synthase/0.441
2zfaFMNLactate oxidase/0.441
3c35KAIGlutamate receptor ionotropic, kainate 1/0.441
3drcMTXDihydrofolate reductase1.5.1.30.441
3ex8AIFRiboflavin biosynthesis protein RibD1.1.1.1930.441
3gwfFADCyclohexanone monooxygenase/0.441
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.441
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.441
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.441
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.441
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4l4eCAMCamphor 5-monooxygenase1.14.15.10.441
4qaiFMNNADPH dehydrogenase/0.441
4xrgNADHomospermidine synthase2.5.1.440.441
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.441
1ipeNDPTropinone reductase 21.1.1.2360.440
1jedADPSulfate adenylyltransferase/0.440
1lbcCYZGlutamate receptor 2/0.440
1pg3PRXAcetyl-coenzyme A synthetase/0.440
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.440
1szcCNANAD-dependent protein deacetylase HST23.5.10.440
1tv5A26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.440
2a5kAZPReplicase polyprotein 1ab3.4.220.440
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.440
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.440
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.440
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.440
2yvgNADFerredoxin reductase/0.440
3d2mCOAAmino-acid acetyltransferase/0.440
3iogSDFMetallo-beta-lactamase type 2/0.440
3otwCOAPhosphopantetheine adenylyltransferase/0.440
3zp4TSAChorismate mutase AroH5.4.99.50.440
4efuEFUHeat shock protein HSP 90-alpha/0.440
4n6hEJ4Delta-type opioid receptor/0.440
4qedNAPElxO/0.440
4tm4FDAKtzI/0.440
5aqzSGVHeat shock 70 kDa protein 1A/0.440
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.440