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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1c1c612Gag-Pol polyprotein2.7.7.49

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1c1c612Gag-Pol polyprotein2.7.7.491.000
1c1bGCAGag-Pol polyprotein2.7.7.490.726
1rt1MKCGag-Pol polyprotein2.7.7.490.615
3dmjGWEPol protein/0.599
3is9AC7Gag-Pol polyprotein2.7.7.490.588
3dokGWJPol protein/0.577
3ffi3OBGag-Pol polyprotein2.7.7.490.575
3lanKBTGag-Pol polyprotein2.7.7.490.572
3dleGFAGag-Pol polyprotein2.7.7.490.571
3irxUDRGag-Pol polyprotein2.7.7.490.571
3lamKRPGag-Pol polyprotein2.7.7.490.566
1tl1H18Gag-Pol polyprotein2.7.7.490.565
1ep4S11Gag-Pol polyprotein2.7.7.490.551
1rt5UC2Gag-Pol polyprotein2.7.7.490.551
1klmSPPGag-Pol polyprotein2.7.7.490.548
1rt4UC1Gag-Pol polyprotein2.7.7.490.544
3dlgGWEGag-Pol polyprotein2.7.7.490.544
3t1a5MAGag-Pol polyprotein2.7.7.490.544
1jlaTNKGag-Pol polyprotein2.7.7.490.543
4i7fNVEGag-Pol polyprotein2.7.7.490.542
1jlcFTCGag-Pol polyprotein2.7.7.490.541
1tl3H20Gag-Pol polyprotein2.7.7.490.540
3dolGWIPol protein/0.540
3i0rRT3Gag-Pol polyprotein2.7.7.490.540
4rw6494Gag-Pol polyprotein2.7.7.490.540
3bgrT27Gag-Pol polyprotein2.7.7.490.539
3lakKR1Gag-Pol polyprotein2.7.7.490.539
3di6PDZGag-Pol polyprotein2.7.7.490.538
2be2R22Gag-Pol polyprotein2.7.7.490.537
3lalKRVGag-Pol polyprotein2.7.7.490.535
1hquHBYGag-Pol polyprotein2.7.7.490.533
1rt7UC4Gag-Pol polyprotein2.7.7.490.532
3c6uM22Gag-Pol polyprotein2.7.7.490.529
1s1vTNKGag-Pol polyprotein2.7.7.490.527
3dyaPZLGag-Pol polyprotein2.7.7.490.527
1rtiHEFGag-Pol polyprotein2.7.7.490.524
3c6tM14Gag-Pol polyprotein2.7.7.490.524
3i0sRT7Gag-Pol polyprotein2.7.7.490.524
4lsl1YQGag-Pol polyprotein2.7.7.490.523
4h4o506Gag-Pol polyprotein2.7.7.490.520
1hpzAAPGag-Pol polyprotein2.7.7.490.517
2wonZZEGag-Pol polyprotein2.7.7.490.517
3qlhT27Gag-Pol polyprotein2.7.7.490.517
4i2pG73Gag-Pol polyprotein2.7.7.490.517
1rt2TNKGag-Pol polyprotein2.7.7.490.516
4rw4494Gag-Pol polyprotein2.7.7.490.516
4h4m494Gag-Pol polyprotein2.7.7.490.514
1s1tUC1Gag-Pol polyprotein2.7.7.490.511
3drrR8EGag-Pol polyprotein2.7.7.490.511
3nbpJGZGag-Pol polyprotein2.7.7.490.510
1tvrTB9Gag-Pol polyprotein2.7.7.490.509
3e01PZ2Gag-Pol polyprotein2.7.7.490.505
4mfb29TGag-Pol polyprotein2.7.7.490.504
2rkiTT1Gag-Pol polyprotein2.7.7.490.503
2ynhEURGag-Pol polyprotein2.7.7.490.501
2zd1T27Gag-Pol polyprotein2.7.7.490.500
4id5T27Gag-Pol polyprotein2.7.7.490.500
5cyqT27Gag-Pol polyprotein2.7.7.490.499
2ynfWHUGag-Pol polyprotein2.7.7.490.497
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.493
3t195MAGag-Pol polyprotein2.7.7.490.492
1rdt570Peroxisome proliferator-activated receptor gamma/0.491
5cb5APRO-acetyl-ADP-ribose deacetylase/0.489
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.488
4g1qT27Gag-Pol polyprotein2.7.7.490.484
3meeT27Gag-Pol polyprotein2.7.7.490.483
4ifvT27Gag-Pol polyprotein2.7.7.490.483
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.482
4mv1ADPBiotin carboxylase6.3.4.140.481
4xldBRLPeroxisome proliferator-activated receptor gamma/0.481
1fm9570Peroxisome proliferator-activated receptor gamma/0.480
2ic3HBYGag-Pol polyprotein2.7.7.490.480
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.480
2jedLG8Protein kinase C theta type2.7.11.130.479
3zep1NXTyrosine-protein kinase JAK32.7.10.20.479
1zgyBRLPeroxisome proliferator-activated receptor gamma/0.478
2b5j3ACGag-Pol polyprotein2.7.7.490.478
1ikxPNUGag-Pol polyprotein2.7.7.490.477
1jlqSBNGag-Pol polyprotein2.7.7.490.477
1hb3SCVIsopenicillin N synthase1.21.3.10.476
1y0s331Peroxisome proliferator-activated receptor delta/0.476
2uxoTACHTH-type transcriptional regulator TtgR/0.476
3gwfFADCyclohexanone monooxygenase/0.476
4kko1REGag-Pol polyprotein2.7.7.490.476
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.476
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.474
2ban357Gag-Pol polyprotein2.7.7.490.474
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.474
4o1mNADEnoyl-acyl carrier reductase/0.474
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.473
3tdaPN0Cytochrome P450 2D6/0.473
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.472
3eek53SUncharacterized protein/0.472
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.472
4b8uIBK3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.472
1bk0ACVIsopenicillin N synthase1.21.3.10.471
3a60STURibosomal protein S6 kinase beta-12.7.11.10.471
4awq592Heat shock protein HSP 90-alpha/0.471
1zw9H64ATP-dependent molecular chaperone HSP82/0.470
3nx4NAPPutative oxidoreductase/0.470
3vt7VDXVitamin D3 receptor/0.470
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.470
1ikyMSDGag-Pol polyprotein2.7.7.490.469
1k74544Peroxisome proliferator-activated receptor gamma/0.469
3iaeD7KBenzaldehyde lyase/0.469
3jziJZLBiotin carboxylase6.3.4.140.469
4l8u9AZSerum albumin/0.469
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
3qm4PN0Cytochrome P450 2D6/0.468
3tamM06Gag-Pol polyprotein2.7.7.490.468
1aq1STUCyclin-dependent kinase 22.7.11.220.467
2ovhAS0Progesterone receptor/0.467
2q8sL92Peroxisome proliferator-activated receptor gamma/0.467
2ykjYKJHeat shock protein HSP 90-alpha/0.467
3inwJZBHeat shock protein HSP 90-alpha/0.467
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.467
1eioGCHGastrotropin/0.466
1iyzNDPProbable quinone oxidoreductase/0.466
2opqHBQGag-Pol polyprotein2.7.7.490.466
3qtzX42Cyclin-dependent kinase 22.7.11.220.466
3vvpBNUUncharacterized protein/0.466
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.466
4jvmXDIEstrogen sulfotransferase2.8.2.40.466
4wa9AXITyrosine-protein kinase ABL12.7.10.20.466
2hw2RFPRifampin ADP-ribosyl transferase/0.465
3a0iAJIGlucokinase2.7.1.20.465
1fmjRTLRetinol dehydratase/0.464
2jn3JN3Fatty acid-binding protein, liver/0.464
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.464
3drpR8EGag-Pol polyprotein2.7.7.490.464
3ezpB3NHistone deacetylase 83.5.1.980.464
3s79ASDAromatase1.14.14.140.464
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.464
1s6qTPBGag-Pol polyprotein2.7.7.490.463
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.463
3vt65YIVitamin D3 receptor/0.463
4e37NDPCatalase1.11.1.60.463
4mk928RGenome polyprotein2.7.7.480.463
1z6tADPApoptotic protease-activating factor 1/0.462
2gtk208Peroxisome proliferator-activated receptor gamma/0.462
2xytTC9Soluble acetylcholine receptor/0.462
3ddpRC8Cyclin-dependent kinase 22.7.11.220.462
3inxJZCHeat shock protein HSP 90-alpha/0.462
3kk6CELProstaglandin G/H synthase 11.14.99.10.462
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.462
4i8vBHFCytochrome P450 1A11.14.14.10.462
2cx8SAHRibosomal RNA small subunit methyltransferase E/0.461
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.461
2ykcYKCHeat shock protein HSP 90-alpha/0.461
3jpuTY4Transcriptional activator protein LasR/0.461
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.461
4dymIYZActivin receptor type-12.7.11.300.461
3sn6P0GBeta-2 adrenergic receptor/0.461
2fwzH71Heat shock protein HSP 90-alpha/0.460
2hk9NAPShikimate dehydrogenase (NADP(+))/0.460
3h1vTK1Glucokinase2.7.1.20.460
3le62BZCyclin-dependent kinase 22.7.11.220.460
3w0aDS5Vitamin D3 receptor/0.460
4hni16WCasein kinase I isoform epsilon2.7.11.10.460
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.459
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.459
2pirDHTAndrogen receptor/0.459
3cv9VDXVitamin D3 dihydroxylase/0.459
3opdHIEHeat shock protein 83/0.459
1ndeMONEstrogen receptor beta/0.458
1s3uTQDDihydrofolate reductase1.5.1.30.458
2ow9SP6Collagenase 33.4.240.458
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
4a9mP9MBromodomain-containing protein 2/0.458
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.458
4qa0SHHHistone deacetylase 83.5.1.980.458
3uzcT4EAdenosine receptor A2a/0.458
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.457
1uomPTIEstrogen receptor/0.457
3d7kD7KBenzaldehyde lyase/0.457
4a4wYFBPeroxisome proliferator-activated receptor gamma/0.457
4xrgNADHomospermidine synthase2.5.1.440.457
5kgpACOPredicted acetyltransferase/0.457
1dnaCB3Thymidylate synthase/0.456
1hniAAAGag-Pol polyprotein2.7.7.490.456
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.456
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.456
2iw94SPCyclin-dependent kinase 22.7.11.220.456
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.456
2w98P1ZProstaglandin reductase 21.3.1.480.456
3cseN22Uncharacterized protein/0.456
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.456
3vspEK8Peroxisome proliferator-activated receptor gamma/0.456
3zkyWT4Isopenicillin N synthase1.21.3.10.456
3zuxTCHTransporter/0.456
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.456
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4nc3ERM5-hydroxytryptamine receptor 2B/0.456
1bsvNDPGDP-L-fucose synthase/0.455
1cjvFOKAdenylate cyclase type 2/0.455
1cjvFOKAdenylate cyclase type 5/0.455
1db1VDXVitamin D3 receptor/0.455
2jb4A14Isopenicillin N synthase1.21.3.10.455
2w4qCBWProstaglandin reductase 21.3.1.480.455
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.455
3qziX72Cyclin-dependent kinase 22.7.11.220.455
3wv9FEGHmd co-occurring protein HcgE/0.455
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4emaBRLPeroxisome proliferator-activated receptor gamma/0.455
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.455
4ipw1G7Mycocyclosin synthase1.14.21.90.455
5bv3M7Gm7GpppX diphosphatase3.6.1.590.455
5kf1ACOPredicted acetyltransferase/0.455
1blzACVIsopenicillin N synthase1.21.3.10.454
1ia2TQ4Dihydrofolate reductase1.5.1.30.454
2ehlSAHDiphthine synthase/0.454
2ovmAS0Progesterone receptor/0.454
2z3uCRRCytochrome P450/0.454
3nr4PYVAbscisic acid receptor PYL2/0.454
3s7a684Dihydrofolate reductase1.5.1.30.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
3sp9IL2Peroxisome proliferator-activated receptor delta/0.454
3w5rLOAVitamin D3 receptor/0.454
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.454
4i6gFADCryptochrome-2/0.454
4mxeACON-acetyltransferase ESCO12.3.10.454
5dozNDPJamJ/0.454
1tl7FOKAdenylate cyclase type 2/0.453
1tl7FOKAdenylate cyclase type 5/0.453
1uykPUXHeat shock protein HSP 90-alpha/0.453
2ath3EAPeroxisome proliferator-activated receptor gamma/0.453
2gvcFADThiol-specific monooxygenase1.14.130.453
2iw84SPCyclin-dependent kinase 22.7.11.220.453
2ykeYKEHeat shock protein HSP 90-alpha/0.453
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3drcMTXDihydrofolate reductase1.5.1.30.453
3eel53TUncharacterized protein/0.453
3mqe416Prostaglandin G/H synthase 21.14.99.10.453
3qlxQLRUncharacterized protein/0.453
3wmxNADNAD dependent epimerase/dehydratase/0.453
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.453
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.453
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.453
4l9kEHFSerum albumin/0.453
1e7qNAPGDP-L-fucose synthase/0.452
1oiuN76Cyclin-dependent kinase 22.7.11.220.452
1rkhVD2Vitamin D3 receptor/0.452
1yinCM3Estrogen receptor/0.452
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.452
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.452
2p4yC03Peroxisome proliferator-activated receptor gamma/0.452
2q5p241Peroxisome proliferator-activated receptor gamma/0.452
2qo9ANPEphrin type-A receptor 32.7.10.10.452
2vg7NNIGag-Pol polyprotein2.7.7.490.452
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.452
3m8qDJZGag-Pol polyprotein2.7.7.490.452
3tk3CPZCytochrome P450 2B41.14.14.10.452
3v94WYQPhosphodiesterase/0.452
4b8zNAPGDP-L-fucose synthase1.1.1.2710.452
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.452
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
4u0oMTALipoyl synthase 2/0.452
3rfmCFFAdenosine receptor A2a/0.452
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1dg5TOPDihydrofolate reductase1.5.1.30.451
1ke6LS2Cyclin-dependent kinase 22.7.11.220.451
2dv7SAHDiphthine synthase/0.451
2ev9NAPShikimate dehydrogenase (NADP(+))/0.451
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.451
2qe4JJ3Estrogen receptor/0.451
3p3zP3ZPutative cytochrome P450/0.451
3w5p4OAVitamin D3 receptor/0.451
3wd7COAAcridone synthase/0.451
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4nyeADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.451
4qa2SHHHistone deacetylase 83.5.1.980.451
4xivACPChemotaxis protein CheA2.7.13.30.451
5kf8ACOPredicted acetyltransferase/0.451
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.450
1kzjCB3Thymidylate synthase/0.450
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1nq7ARLNuclear receptor ROR-beta/0.450
1uyfPU1Heat shock protein HSP 90-alpha/0.450
2cchATPCyclin-dependent kinase 22.7.11.220.450
2emuSAHDiphthine synthase/0.450
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2h55DZ8Heat shock protein HSP 90-alpha/0.450
2o4rVD5Vitamin D3 receptor/0.450
2zjwREFCasein kinase II subunit alpha2.7.11.10.450
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.450
3s0o50ZCyclin-dependent kinase 22.7.11.220.450
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.450
3sw719KCyclin-dependent kinase 22.7.11.220.450
3vev0H4Glucokinase2.7.1.20.450
3w5tLHPVitamin D3 receptor/0.450
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.450
4ogrADNCyclin-dependent kinase 92.7.11.220.450
1olmVTQSEC14-like protein 2/0.449
1uydPU8Heat shock protein HSP 90-alpha/0.449
1zhzERGOxysterol-binding protein homolog 4/0.449
2ibzSMACytochrome b/0.449
2pobGW4Peroxisome proliferator-activated receptor gamma/0.449
3frqERYErythromycin resistance repressor protein/0.449
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.449
3lu8IQXSerum albumin/0.449
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.449
3q9oNADCholix toxin2.4.2.360.449
3unk0BYCyclin-dependent kinase 22.7.11.220.449
3uoyNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.449
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.449
3zkuHCVIsopenicillin N synthase1.21.3.10.449
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.449
4y8vADPAcyl-CoA synthetase (NDP forming)/0.449
5a3cNADSIR2 family protein/0.449
1hnvTBOGag-Pol polyprotein2.7.7.490.448
1q5dEPBEpothilone C/D epoxidase1.140.448
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1tw2ERTCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.448
1xkdNAPIsocitrate dehydrogenase [NADP]/0.448
2cig1DGDihydrofolate reductase1.5.1.30.448
2e7rSAHDiphthine synthase/0.448
2hj3FADFAD-linked sulfhydryl oxidase ERV1/0.448
2imfTOM2-hydroxychromene-2-carboxylate isomerase5.99.1.40.448
3bgxMEFThymidylate synthase/0.448
3cd2MTXDihydrofolate reductase1.5.1.30.448
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.448
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.448
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.448
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4gk4L90Ephrin type-A receptor 32.7.10.10.448
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
5kf9ACOPredicted acetyltransferase/0.448
1ek2CDUBifunctional epoxide hydrolase 2/0.447
1f4gTP4Thymidylate synthase/0.447
1m79MQ1Dihydrofolate reductase1.5.1.30.447
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.447
2vqoTFGHistone deacetylase 43.5.1.980.447
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.447
2znpK55Peroxisome proliferator-activated receptor delta/0.447
2znq401Peroxisome proliferator-activated receptor delta/0.447
3vt8YI3Vitamin D3 receptor/0.447
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.447
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.447
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.447
4kfbT27Gag-Pol polyprotein2.7.7.490.447
4mlhVO2Glucokinase2.7.1.20.447
3reyXACAdenosine receptor A2a/0.447
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1gii1PUCyclin-dependent kinase 22.7.11.220.446
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1pd9CO4Dihydrofolate reductase1.5.1.30.446
1txiTX5Vitamin D3 receptor/0.446
1vceSAHDiphthine synthase/0.446
2fzhDH1Dihydrofolate reductase1.5.1.30.446
2lbaCHOFatty acid binding protein 6/0.446
2oppHBQGag-Pol polyprotein2.7.7.490.446
2owuSAHDiphthine synthase/0.446
2vnhFADNADPH:ferredoxin reductase/0.446
2w05FRTCyclin-dependent kinase 22.7.11.220.446
2znnS44Peroxisome proliferator-activated receptor alpha/0.446
3l0lHC3Nuclear receptor ROR-gamma/0.446
3ns2PYVAbscisic acid receptor PYL2/0.446
3qly55VUncharacterized protein/0.446
3sruQ26Dihydrofolate reductase1.5.1.30.446
3t8xT8XT-cell surface glycoprotein CD1b/0.446
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
3wy0COAUncharacterized protein/0.446
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.446
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.446
4b2gV1NUncharacterized protein/0.446
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.446
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4ia7BIVVitamin D3 receptor A/0.446
4ib4ERM5-hydroxytryptamine receptor 2B/0.446
4iw61GUEstrogen receptor/0.446
4r20AERCytochrome P450 family 17 polypeptide 2/0.446
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.446
5hs1VORLanosterol 14-alpha demethylase/0.446
5uviZMAAdenosine receptor A2a/0.446
3qakUKAAdenosine receptor A2a/0.446
1m7aMQUDihydrofolate reductase1.5.1.30.445
1oi9N20Cyclin-dependent kinase 22.7.11.220.445
1pkfEPDEpothilone C/D epoxidase1.140.445
1xddAAYIntegrin alpha-L/0.445
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.445
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
2oaxSNLMineralocorticoid receptor/0.445
2vagV25Dual specificity protein kinase CLK12.7.12.10.445
2vbdV10Isopenicillin N synthase1.21.3.10.445
2wo7ASVIsopenicillin N synthase1.21.3.10.445
2znoS44Peroxisome proliferator-activated receptor gamma/0.445
3a1l2CCCytochrome P450/0.445
3d5fL41Peroxisome proliferator-activated receptor delta/0.445
3pe13NGCasein kinase II subunit alpha2.7.11.10.445
3phiNDPShikimate dehydrogenase (NADP(+))/0.445
3rmf20ZCyclin-dependent kinase 22.7.11.220.445
4a83DXCMajor pollen allergen Bet v 1-A/0.445
4eop1ROCyclin-dependent kinase 22.7.11.220.445
4hee14RPeroxisome proliferator-activated receptor gamma/0.445
4ix6ADPUncharacterized protein/0.445
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
4qa1B3NHistone deacetylase 83.5.1.980.445
4y95746Tyrosine-protein kinase/0.445
5c1mCLRMu-type opioid receptor/0.445
5d1bTSNHistone deacetylase 83.5.1.980.445
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.445
5e8ySTUTGF-beta receptor type-22.7.11.300.445
1amoNAPNADPH--cytochrome P450 reductase/0.444
1s19MC9Vitamin D3 receptor/0.444
1zhwHC2Oxysterol-binding protein homolog 4/0.444
2bgjFADNADPH:ferredoxin reductase/0.444
2bxnIDBSerum albumin/0.444
2ittAEEEpidermal growth factor receptor2.7.10.10.444
2opsHBQGag-Pol polyprotein2.7.7.490.444
2ph5NADHomospermidine synthase/0.444
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.444
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.444
3fl8RARDihydrofolate reductase/0.444
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.444
3nj0PYVAbscisic acid receptor PYL2/0.444
3srwQ27Dihydrofolate reductase1.5.1.30.444
4awo99BHeat shock protein HSP 90-alpha/0.444
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4iteTEYVitamin D3 receptor/0.444
4j6cSTRCytochrome P450 monooxygenase/0.444
4qmpDKISerine/threonine-protein kinase 242.7.11.10.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
4uymVOR14-alpha sterol demethylase Cyp51B/0.444
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.444
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
5dc5B3NHistone deacetylase 83.5.1.980.444
1bw9NADPhenylalanine dehydrogenase/0.443
1dhiMTXDihydrofolate reductase1.5.1.30.443
1kkq471Peroxisome proliferator-activated receptor alpha/0.443
1r2jFADFkbI/0.443
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2g5oDRQEstrogen receptor/0.443
2hcdBIVVitamin D3 receptor A/0.443
2oyuIMSProstaglandin G/H synthase 11.14.99.10.443
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.443
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.443
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3gcoVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.443
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.443
3pm0BHFCytochrome P450 1B1/0.443
3qlrNDPDihydrofolate reductase1.5.1.30.443
3s1dZIRCytokinin dehydrogenase 11.5.99.120.443
3t2kFADSulfide-quinone reductase/0.443
3vt5YI2Vitamin D3 receptor/0.443
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.443
4em9TCEPeroxisome proliferator-activated receptor gamma/0.443
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4h9814QUncharacterized protein/0.443
4isf1FXGlucokinase2.7.1.20.443
4okx198Androgen receptor/0.443
5envNADAlcohol dehydrogenase 11.1.1.10.443
1cbrREACellular retinoic acid-binding protein 1/0.442
1crbRTLRetinol-binding protein 1/0.442
1ie8KH1Vitamin D3 receptor/0.442
1jpaANPEphrin type-B receptor 22.7.10.10.442
1xudPB4Collagenase 33.4.240.442
2c6tDT5Cyclin-dependent kinase 22.7.11.220.442
2rabNADGlutathione amide reductase/0.442
2vkeTACTetracycline repressor protein class D/0.442
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.442
3qiyQI1Botulinum neurotoxin type A3.4.24.690.442
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.442
4b7dQLECytochrome P450 monooxygenase PikC/0.442
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4g1z0VPVitamin D3 receptor A/0.442
4i3wNADAldehyde dehydrogenase (NAD+)/0.442
4imoPWZProstaglandin-H2 D-isomerase5.3.99.20.442
4jvnYUGEstrogen sulfotransferase2.8.2.40.442
4ko0JLJGag-Pol polyprotein2.7.7.490.442
4r21STRCytochrome P450 family 17 polypeptide 2/0.442
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.442
1an5CB3Thymidylate synthase/0.441
1ly3COGDihydrofolate reductase1.5.1.30.441
1oc1ASVIsopenicillin N synthase1.21.3.10.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.441
2jf9OHTEstrogen receptor/0.441
2oprHBQGag-Pol polyprotein2.7.7.490.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
2w8y486Progesterone receptor/0.441
3ft8MOJHeat shock protein HSP 90-alpha/0.441
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.441
3gc9B45Mitogen-activated protein kinase 112.7.11.240.441
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.441
3pqbVGPPutative oxidoreductase/0.441
3r9oZ71Cyclin-dependent kinase 22.7.11.220.441
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.441
3w5q3KLVitamin D3 receptor/0.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4fcr0TMHeat shock protein HSP 90-alpha/0.441
4grb0XGCasein kinase II subunit alpha2.7.11.10.441
4j6bPLOCytochrome P450 monooxygenase/0.441
4jlk1NODeoxycytidine kinase2.7.1.740.441
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.441
4mr61K0Bromodomain-containing protein 2/0.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1bwsNDPGDP-L-fucose synthase/0.440
1ia4TQ6Dihydrofolate reductase1.5.1.30.440
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
2e8qSAHDiphthine synthase/0.440
2eh5SAHDiphthine synthase/0.440
2eniSAHDiphthine synthase/0.440
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.440
2j14GNIPeroxisome proliferator-activated receptor delta/0.440
2npaMMBPeroxisome proliferator-activated receptor alpha/0.440
2p6kSAHDiphthine synthase/0.440
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.440
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
3bg7FADPyranose 2-oxidase/0.440
3ijdC2FMethylenetetrahydrofolate reductase/0.440
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3r0tFU9Casein kinase II subunit alpha2.7.11.10.440
3rbqGLY_ALA_GLY_DAOProtein unc-119 homolog A/0.440
3rpv26ZCyclin-dependent kinase 22.7.11.220.440
3thrC2FGlycine N-methyltransferase2.1.1.200.440
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.440
4c61LMMTyrosine-protein kinase JAK2/0.440
4cd2FOLDihydrofolate reductase1.5.1.30.440
4e0iFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.440
4fj1GEN17beta-hydroxysteroid dehydrogenase/0.440
4jlj1NMDeoxycytidine kinase2.7.1.740.440
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.440
4ku5DCC3-oxoacyl-[ACP] synthase III/0.440
4ryvZEAProtein LlR18A/0.440
4y7cNAPNADPH--cytochrome P450 reductase/0.440
5dp2NAPCurF/0.440