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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1c0kFADD-amino-acid oxidase1.4.3.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1c0kFADD-amino-acid oxidase1.4.3.31.000
1c0lFADD-amino-acid oxidase1.4.3.30.768
4n9iPCGCatabolite expression activator/0.514
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.478
4eueNAITrans-2-enoyl-CoA reductase [NADH]/0.476
1orrNADCDP-paratose 2-epimerase/0.475
1rp0AHZThiamine thiazole synthase, chloroplastic/0.470
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.468
3clsFADElectron transfer flavoprotein subunit alpha/0.467
3clrFADElectron transfer flavoprotein subunit alpha/0.466
4eqwFADCoenzyme A disulfide reductase/0.466
4rpgFADUDP-galactopyranose mutase5.4.99.90.466
3f8rNAPNADH oxidase/thioredoxin reductase/0.464
2py7ATPPhosphoenolpyruvate carboxykinase (ATP)/0.463
4fxy0W2Neurolysin, mitochondrial3.4.24.160.461
4zohFADPutative oxidoreductase FAD-binding subunit/0.460
4wxlBB2Peptide deformylase/0.459
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.458
1gheACOAcetyltransferase2.3.10.455
2a94AP0L-lactate dehydrogenase1.1.1.270.453
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
4bk3FADProbable salicylate monooxygenase/0.453
3muoZPRProlyl endopeptidase/0.452
1lbcCYZGlutamate receptor 2/0.451
3ad9NADSubunit alpha of sarocosine oxidase/0.450
3ge6FMNNitroreductase/0.450
4kwhNAPReductase homolog/0.450
4nmdFDABifunctional protein PutA/0.450
1tqf32PBeta-secretase 13.4.23.460.449
1ybmNAPUncharacterized protein At5g02240/0.449
4xgxADPFAD:protein FMN transferase/0.449
1p9wANPType II secretion system protein E/0.448
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4b69FADL-ornithine N(5)-monooxygenase/0.448
1gthFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.447
1lruBB2Peptide deformylase3.5.1.880.447
4eqsFADCoenzyme A disulfide reductase/0.447
2g9uG27Glycogen phosphorylase, muscle form2.4.1.10.446
3cgfJNFMitogen-activated protein kinase 102.7.11.240.446
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.446
4qecNAPElxO/0.446
4u2tFADCholesterol oxidase1.1.3.60.446
2q4bNAPUncharacterized protein At5g02240/0.445
3e8xNAPBH1520 protein/0.445
3vthAP2Carbamoyltransferase/0.445
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.445
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.445
5ftcADPTPR domain protein/0.445
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
2gjnFMNNitronate monooxygenase1.13.12.160.444
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.444
3nbvANPKetohexokinase/0.444
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.444
4ww0ADPATP-dependent zinc metalloprotease FtsH/0.444
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.443
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.443
1hdrNADDihydropteridine reductase1.5.1.340.443
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.443
2dwbANPAurora kinase A2.7.11.10.443
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.443
3eljGS7Mitogen-activated protein kinase 82.7.11.240.443
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.443
3pcrGTPADP-ribosylation factor 6/0.443
3r4pFU7Heat shock protein HSP 90-alpha/0.443
4giu636Anthranilate phosphoribosyltransferase/0.443
3frqERYErythromycin resistance repressor protein/0.442
3qrwNDPPutative ketoacyl reductase1.3.10.442
3td7FADProbable FAD-linked sulfhydryl oxidase R5961.8.3.20.442
4i02CMPcAMP-activated global transcriptional regulator CRP/0.442
1i3mUD1UDP-glucose 4-epimerase/0.441
1jvdUD1UDP-N-acetylhexosamine pyrophosphorylase2.7.7.230.441
1l7eNAINAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2pmoHMDProtein kinase 7/0.441
2x0rNADMalate dehydrogenase/0.441
3gy0NAPNAD(P)-dependent oxidoreductase/0.441
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
1f20FADNitric oxide synthase, brain1.14.13.390.440
1ma0NADAlcohol dehydrogenase class-31.1.1.10.440
1me6IVSPlasmepsin-23.4.23.390.440
4u0oMTALipoyl synthase 2/0.440
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.440
5kgpACOPredicted acetyltransferase/0.440