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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bx9GLY_GGL_FOEGlutathione S-transferase F22.5.1.18

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bx9GLY_GGL_FOEGlutathione S-transferase F22.5.1.181.000
1hfqMOTDihydrofolate reductase1.5.1.30.503
1oc1ASVIsopenicillin N synthase1.21.3.10.493
2y6fM9FIsopenicillin N synthase1.21.3.10.489
3pm1ETHTH-type transcriptional regulator QacR/0.484
1blzACVIsopenicillin N synthase1.21.3.10.482
1bk0ACVIsopenicillin N synthase1.21.3.10.473
1synF89Thymidylate synthase/0.472
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.469
4b2gV1NUncharacterized protein/0.469
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
2jb4A14Isopenicillin N synthase1.21.3.10.466
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.466
3v94WYQPhosphodiesterase/0.465
2vbpVB1Isopenicillin N synthase1.21.3.10.464
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.463
1o97FADElectron transfer flavoprotein subunit alpha/0.462
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2vbdV10Isopenicillin N synthase1.21.3.10.462
3qe2FMNNADPH--cytochrome P450 reductase/0.462
2iviACWIsopenicillin N synthase1.21.3.10.461
2vcmM11Isopenicillin N synthase1.21.3.10.459
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.459
3e5aVX6Aurora kinase A2.7.11.10.459
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.458
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3zkyWT4Isopenicillin N synthase1.21.3.10.457
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.456
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.456
4bb3KKAIsopenicillin N synthase1.21.3.10.456
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4iwv1J9Glucokinase2.7.1.20.455
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.454
4jb1NAPUDP-N-acetylenolpyruvoylglucosamine reductase/0.454
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
5irnADPNucleotide binding oligomerization domain containing 2/0.453
3pqbVGPPutative oxidoreductase/0.452
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.452
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.451
1d3dBZTProthrombin3.4.21.50.450
1disBDMDihydrofolate reductase1.5.1.30.450
1e1kFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.450
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
4l8u9AZSerum albumin/0.450
3uzcT4EAdenosine receptor A2a/0.450
1obnASVIsopenicillin N synthase1.21.3.10.449
3br3ETHTH-type transcriptional regulator QacR/0.449
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.449
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.448
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3zeiAWHO-acetylserine sulfhydrylase/0.448
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.448
5fd8A5APutative carboxypeptidase yocD/0.448
1pq6965Oxysterols receptor LXR-beta/0.447
1uzwCDHIsopenicillin N synthase1.21.3.10.447
3dds26BGlycogen phosphorylase, liver form2.4.1.10.447
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2x7hPFNProstaglandin reductase 310.446
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
1fxsNAPGDP-L-fucose synthase/0.445
1g63FMNEpidermin decarboxylase4.1.10.445
1hb1OCVIsopenicillin N synthase1.21.3.10.445
2bu9HFVIsopenicillin N synthase1.21.3.10.445
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
3g70A5TRenin3.4.23.150.445
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.445
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.445
1hb3SCVIsopenicillin N synthase1.21.3.10.444
1pd9CO4Dihydrofolate reductase1.5.1.30.444
1qjfACSIsopenicillin N synthase1.21.3.10.444
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.444
3zkuHCVIsopenicillin N synthase1.21.3.10.444
4cdmFO1Deoxyribodipyrimidine photolyase/0.444
1ndzFR5Adenosine deaminase3.5.4.40.443
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
1s3uTQDDihydrofolate reductase1.5.1.30.442
2ejzSAHDiphthine synthase/0.442
2i4qUA4Renin3.4.23.150.442
3p3zP3ZPutative cytochrome P450/0.442
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.442
4epq0RRPoly(ADP-ribose) glycohydrolase/0.442
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.441
1pqc444Oxysterols receptor LXR-beta/0.441
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3up0D7SaceDAF-12/0.441
4kebFOLDihydrofolate reductase1.5.1.30.441
4uyf73BBromodomain-containing protein 2/0.441
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.441
1umlFR4Adenosine deaminase3.5.4.40.440
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3oqkS52Renin3.4.23.150.440
5dp2NAPCurF/0.440