sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 1.000 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.655 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.652 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.632 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.629 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.628 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.621 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.620 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.617 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.614 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.611 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.610 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.608 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.602 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.602 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.592 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.584 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.583 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.582 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.580 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.579 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.579 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.579 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.578 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.576 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.572 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.571 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.566 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.566 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.565 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.564 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.563 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.561 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.559 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.557 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.557 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.556 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.556 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.555 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.554 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.553 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.552 | |
| 2xs4 | ALA_PHE_THR | Karilysin | 3.4.24 | 0.548 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.548 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.547 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.547 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.544 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.543 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.543 | |
| 1mnc | PLH | Neutrophil collagenase | 3.4.24.34 | 0.542 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.540 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.539 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.538 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.537 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.537 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.533 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.533 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.532 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.532 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.529 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.529 | |
| 1fm1 | WAY | Collagenase 3 | 3.4.24 | 0.528 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.528 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.526 | |
| 1dth | BAT | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.525 | |
| 2xs3 | ALA_PHE_THR_SER | Karilysin | 3.4.24 | 0.521 | |
| 3e8r | 615 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.521 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.518 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.517 | |
| 1rm8 | BAT | Matrix metalloproteinase-16 | 3.4.24 | 0.513 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.513 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.508 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.503 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.503 | |
| 2dw0 | GM6 | Zinc metalloproteinase-disintegrin-like VAP2B | 3.4.24 | 0.499 | |
| 2y6d | TQJ | Matrilysin | 3.4.24.23 | 0.498 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.497 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.496 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.494 | |
| 4c3s | NAD | Aldehyde Dehydrogenase | / | 0.493 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.491 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.491 | |
| 4rx6 | ATP | Nitrogen regulatory PII-like protein | / | 0.488 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.487 | |
| 2srt | INH | Stromelysin-1 | 3.4.24.17 | 0.485 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.484 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.484 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.484 | |
| 2i47 | KGY | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.483 | |
| 2z2d | HSI | Macrophage metalloelastase | 3.4.24.65 | 0.482 | |
| 3b92 | 440 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.481 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.479 | |
| 3lgp | 50X | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.478 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.478 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.477 | |
| 2oy2 | ILE_ALA_GLY | Neutrophil collagenase | 3.4.24.34 | 0.477 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.477 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.476 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4tm1 | FDA | KtzI | / | 0.475 | |
| 1zxc | IH6 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.474 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.474 | |
| 3ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.474 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.474 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.472 | |
| 3eks | CY9 | Actin-5C | / | 0.472 | |
| 3kmc | 403 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.472 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.472 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.472 | |
| 2q0u | LAB | Actin, alpha skeletal muscle | / | 0.470 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.470 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.470 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.470 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.469 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.469 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.469 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.468 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.468 | |
| 3zcb | ATP | Adenosine monophosphate-protein transferase VbhT | 2.7.7.n1 | 0.468 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.468 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.468 | |
| 2fr3 | REA | Cellular retinoic acid-binding protein 2 | / | 0.467 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.467 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.466 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.466 | |
| 4ih6 | 1EP | Genome polyprotein | 2.7.7.48 | 0.466 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.466 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.466 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.465 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.464 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.464 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.464 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.464 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.463 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.463 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.463 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.463 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.463 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.462 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.462 | |
| 3ruv | ANP | Chaperonin | / | 0.462 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.462 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.461 | |
| 2v1a | FMN | NPH1-1 | / | 0.461 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.461 | |
| 3l0t | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.461 | |
| 4cj3 | E4F | Integrase | / | 0.461 | |
| 4cki | ADN | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.461 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.461 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.460 | |
| 1fls | WAY | Collagenase 3 | 3.4.24 | 0.460 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 4bix | ADP | Sensor histidine kinase CpxA | / | 0.460 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.460 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.460 | |
| 3m8c | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.459 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.459 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.459 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.459 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.458 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.458 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.458 | |
| 3mwu | BK3 | Calmodulin-domain protein kinase 1, putative | / | 0.458 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4yqf | GDP | Septin-9 | / | 0.458 | |
| 5c88 | COA | N-alpha-acetyltransferase | / | 0.458 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.457 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.456 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.456 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.455 | |
| 1kif | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.455 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.455 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.455 | |
| 4cer | VL4 | Integrase | / | 0.455 | |
| 4ih7 | 1ER | Genome polyprotein | 2.7.7.48 | 0.455 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.455 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.454 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.454 | |
| 3gh8 | FMN | Iodotyrosine deiodinase 1 | 1.21.1.1 | 0.454 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.454 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.454 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.454 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.454 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.454 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.454 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.453 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.453 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.453 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.453 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.453 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.452 | |
| 2y65 | ADP | Kinesin heavy chain | / | 0.452 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.452 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.452 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 4hj6 | FMN | LOV protein | / | 0.452 | |
| 4jkv | 1KS | Smoothened homolog | / | 0.452 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.452 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.451 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.451 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.451 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.451 | |
| 2dek | SAH | Diphthine synthase | / | 0.451 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.451 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.451 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.451 | |
| 3wdl | ATP | 4-phosphopantoate--beta-alanine ligase | 6.3.2.36 | 0.451 | |
| 4ck2 | NVU | Integrase | / | 0.451 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 4tlx | FDA | KtzI | / | 0.451 | |
| 5cae | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.451 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.450 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.450 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.450 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.450 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.450 | |
| 3fr0 | AJB | Glucokinase | 2.7.1.2 | 0.450 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.450 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.450 | |
| 4b64 | FAD | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4hxy | NDP | Plm1 | / | 0.450 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.450 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.449 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.449 | |
| 1nqw | 5YL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.449 | |
| 1rm5 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.449 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.449 | |
| 2a1u | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.449 | |
| 2ejz | SAH | Diphthine synthase | / | 0.449 | |
| 2i47 | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.449 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.449 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3bva | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3d1y | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.449 | |
| 3ieu | GDP | GTPase Era | / | 0.449 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.449 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.449 | |
| 4hnh | NAP | NAD-dependent epimerase/dehydratase | / | 0.449 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.449 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.449 | |
| 4oi2 | ADP | Protein clpf-1 | / | 0.449 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.449 | |
| 5kje | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.448 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.448 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.448 | |
| 1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.448 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.448 | |
| 3dl0 | AP5 | Adenylate kinase | / | 0.448 | |
| 3law | GNP | Ras-related protein Rab-7a | / | 0.448 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.448 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4kgm | ATP | Uncharacterized protein | / | 0.448 | |
| 4mk7 | 28O | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.448 | |
| 5kjf | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.447 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.447 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.447 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.447 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.447 | |
| 2xfj | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.447 | |
| 3bhl | THG | Thymidylate synthase | / | 0.447 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.447 | |
| 4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.447 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.447 | |
| 4to3 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.447 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.447 | |
| 1lke | DOG | Bilin-binding protein | / | 0.446 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.446 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.446 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.446 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 2itw | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 2jnp | NGH | Stromelysin-1 | 3.4.24.17 | 0.446 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.446 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 3stw | 2TD | Methylketone synthase I | / | 0.446 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.446 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.446 | |
| 4y8v | ADP | Acyl-CoA synthetase (NDP forming) | / | 0.446 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.445 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1w4a | APC | NTPase P4 | / | 0.445 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.445 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.445 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.445 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.445 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.445 | |
| 4krs | 1SX | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.445 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.445 | |
| 1axg | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1ffi | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.444 | |
| 2fiw | ACO | GCN5-related N-acetyltransferase:Aminotransferase, class-II | / | 0.444 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3pjt | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.444 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.444 | |
| 4cea | ZSW | Integrase | / | 0.444 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.444 | |
| 4otw | DB8 | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.444 | |
| 5kcp | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1fgc | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.443 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.443 | |
| 1i7l | ATP | Synapsin-2 | / | 0.443 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.443 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.443 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2ejk | SAH | Diphthine synthase | / | 0.443 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.443 | |
| 2igy | A2T | Plasmepsin 2 | / | 0.443 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.443 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3le9 | 727 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.443 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.442 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2iw5 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 2jib | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.442 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.442 | |
| 2qd7 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3l0v | 724 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.442 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.442 | |
| 3mje | NDP | AmphB | / | 0.442 | |
| 3o9c | K20 | Pol polyprotein | / | 0.442 | |
| 3ruq | ADP | Chaperonin | / | 0.442 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.442 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 5cnn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.442 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.442 | |
| 1b6p | PI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1ijj | LAR | Actin, alpha skeletal muscle | / | 0.441 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.441 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.441 | |
| 2eer | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.441 | |
| 2q5q | KPV | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.441 | |
| 2yww | ATP | Aspartate carbamoyltransferase regulatory chain | / | 0.441 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 3iob | A4D | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.441 | |
| 3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 3nyg | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.441 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.441 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.441 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.441 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1i5b | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 | |
| 1jay | F42 | F420-dependent NADP reductase | / | 0.440 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.440 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.440 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.440 | |
| 1kv2 | B96 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 1osv | CHC | Bile acid receptor | / | 0.440 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.440 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.440 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2a4f | AAU | V-1 protease | / | 0.440 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.440 | |
| 2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.440 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.440 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.440 | |
| 3d76 | NBB | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 3qcz | ANP | Dihydrofolate synthase/folylpolyglutamate synthase | / | 0.440 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.440 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.440 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4dqc | 017 | Gag-Pol polyprotein | / | 0.440 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.440 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.440 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.440 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 |