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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bpjUMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bpjUMPThymidylate synthase/1.000
1tsyUMPThymidylate synthase/0.669
1tsxUMPThymidylate synthase/0.659
2g8aUMPThymidylate synthase/0.658
2g86UMPThymidylate synthase/0.644
1njeDCMThymidylate synthase/0.613
1tsvUMPThymidylate synthase/0.609
2tdmUMPThymidylate synthase/0.597
2g89UMPThymidylate synthase/0.548
1bp6UMPThymidylate synthase/0.547
1njdUMPThymidylate synthase/0.547
1jmgUMPThymidylate synthase/0.536
1jmhUMPThymidylate synthase/0.525
1jmiUMPThymidylate synthase/0.522
1vzbUMPThymidylate synthase/0.520
1vzaUMPThymidylate synthase/0.514
1lcbTMPThymidylate synthase/0.510
1jmfUMPThymidylate synthase/0.500
1njbUMPThymidylate synthase/0.490
1njaDCMThymidylate synthase/0.479
1njcDCMThymidylate synthase/0.476
1bidUMPThymidylate synthase/0.466
2tddTHFThymidylate synthase/0.458
1thyUMPThymidylate synthase/0.454
3bgxTMPThymidylate synthase/0.448
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1tdcUMPThymidylate synthase/0.442
2vetUMPThymidylate synthase/0.440