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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bp0UMPThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bp0UMPThymidylate synthase/1.000
1bp6UMPThymidylate synthase/0.651
1tsyUMPThymidylate synthase/0.641
1jmiUMPThymidylate synthase/0.633
2g89UMPThymidylate synthase/0.623
1njcDCMThymidylate synthase/0.602
1jmhUMPThymidylate synthase/0.590
1njbUMPThymidylate synthase/0.587
1njdUMPThymidylate synthase/0.585
1jmfUMPThymidylate synthase/0.583
1njaDCMThymidylate synthase/0.577
2g8aUMPThymidylate synthase/0.577
1jmgUMPThymidylate synthase/0.568
1tdcUMPThymidylate synthase/0.560
2g86UMPThymidylate synthase/0.550
1lcbTMPThymidylate synthase/0.546
1tsxUMPThymidylate synthase/0.542
2g8dUMPThymidylate synthase/0.542
1aobDDUThymidylate synthase/0.538
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.536
1vzdCB3Thymidylate synthase/0.531
4einNOHThymidylate synthase2.1.1.450.530
1vzaUMPThymidylate synthase/0.526
4dq1UMPThymidylate synthase/0.524
1njeDCMThymidylate synthase/0.520
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.519
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.517
4e5oUMPThymidylate synthase2.1.1.450.515
1j3jUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.513
1bidUMPThymidylate synthase/0.510
1bpjUMPThymidylate synthase/0.508
4eb4UMPThymidylate synthase2.1.1.450.506
1vzbUMPThymidylate synthase/0.505
2tdmUMPThymidylate synthase/0.504
1tsvUMPThymidylate synthase/0.500
1lcbDHFThymidylate synthase/0.498
1bduDURThymidylate synthase/0.493
2vetUMPThymidylate synthase/0.483
4h0uUMPThymidylate synthase/0.478
1thyUMPThymidylate synthase/0.473
4rvfTYDD-mycarose 3-C-methyltransferase/0.450
3qj7UMPThymidylate synthase ThyA/0.448
4lrrCF9Thymidylate synthase/0.448
4irrUMPThymidylate synthase/0.440