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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bozPRDDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bozPRDDihydrofolate reductase1.5.1.31.000
1hfpMOTDihydrofolate reductase1.5.1.30.684
1s3wTQTDihydrofolate reductase1.5.1.30.670
4ddrMMVDihydrofolate reductase1.5.1.30.635
4g95OAGDihydrofolate reductase1.5.1.30.616
4kfj1R0Dihydrofolate reductase1.5.1.30.609
4kak06UDihydrofolate reductase1.5.1.30.591
1pd8CO4Dihydrofolate reductase1.5.1.30.588
2w3aTOPDihydrofolate reductase1.5.1.30.585
1mvsDTMDihydrofolate reductase1.5.1.30.571
4kd79DRDihydrofolate reductase1.5.1.30.568
3nxoD2BDihydrofolate reductase1.5.1.30.560
3k47D09Dihydrofolate reductase1.5.1.30.557
1u72MTXDihydrofolate reductase1.5.1.30.556
3nxtD2EDihydrofolate reductase1.5.1.30.556
3nxrD2DDihydrofolate reductase1.5.1.30.553
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.550
3nxvD2FDihydrofolate reductase1.5.1.30.546
3cseN22Uncharacterized protein/0.543
3eigMTXDihydrofolate reductase1.5.1.30.542
3nxyD2HDihydrofolate reductase1.5.1.30.542
1hfqMOTDihydrofolate reductase1.5.1.30.538
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.535
3oafOAGDihydrofolate reductase1.5.1.30.531
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.531
4qjcIXEDihydrofolate reductase1.5.1.30.531
3qly55VUncharacterized protein/0.530
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.529
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.527
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.522
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.522
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.522
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.521
1dr4HBIDihydrofolate reductase1.5.1.30.519
1aoeGW3Dihydrofolate reductase1.5.1.30.518
3eek53SUncharacterized protein/0.516
1klkPMDDihydrofolate reductase1.5.1.30.514
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.514
4m6l21VDihydrofolate reductase1.5.1.30.514
4g8zTOPDihydrofolate reductase1.5.1.30.511
4h9506UDihydrofolate reductase1.5.1.30.511
2w3mFOLDihydrofolate reductase1.5.1.30.509
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.509
1ohjCOPDihydrofolate reductase1.5.1.30.508
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.508
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.508
4h9814QUncharacterized protein/0.507
3qlzQLZUncharacterized protein/0.506
1hfrMOTDihydrofolate reductase1.5.1.30.504
4kebFOLDihydrofolate reductase1.5.1.30.503
2cd2FOLDihydrofolate reductase1.5.1.30.502
1cd2FOLDihydrofolate reductase1.5.1.30.501
1fmjRTLRetinol dehydratase/0.501
1m78CLZDihydrofolate reductase1.5.1.30.501
3ntz3TZDihydrofolate reductase1.5.1.30.500
4ixeIXEDihydrofolate reductase1.5.1.30.500
1dg5TOPDihydrofolate reductase1.5.1.30.499
3ghwGHWDihydrofolate reductase1.5.1.30.499
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.498
4h9614QDihydrofolate reductase1.5.1.30.498
1dg7WRBDihydrofolate reductase1.5.1.30.497
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.495
1pd9CO4Dihydrofolate reductase1.5.1.30.494
3l3rOAGDihydrofolate reductase1.5.1.30.494
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.493
3qlrQLRDihydrofolate reductase1.5.1.30.493
3qlxQLRUncharacterized protein/0.492
1vj3TABDihydrofolate reductase1.5.1.30.491
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.491
4h9753SDihydrofolate reductase1.5.1.30.490
4kbn25UDihydrofolate reductase1.5.1.30.490
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.488
2fziDH3Dihydrofolate reductase1.5.1.30.488
2rhrEMOPutative ketoacyl reductase1.3.10.488
4qa0SHHHistone deacetylase 83.5.1.980.485
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.484
4ixfIXFDihydrofolate reductase1.5.1.30.481
1s3vTQDDihydrofolate reductase1.5.1.30.480
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.480
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.480
3gi2GHWDihydrofolate reductase1.5.1.30.479
3gyf51PDihydrofolate reductase1.5.1.30.478
3p3zP3ZPutative cytochrome P450/0.478
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.478
1e26GPBDihydrofolate reductase1.5.1.30.477
1ia1TQ3Dihydrofolate reductase1.5.1.30.475
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.475
3qls55VDihydrofolate reductase1.5.1.30.475
2w3vTOPDihydrofolate reductase/0.474
3eej53RUncharacterized protein/0.474
3eem53VUncharacterized protein/0.473
3td8D2RDihydrofolate reductase1.5.1.30.473
2fzjDH3Dihydrofolate reductase1.5.1.30.472
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.472
2nq8ZIDEnoyl-ACP reductase/0.471
3eel53TUncharacterized protein/0.470
1dr3HBIDihydrofolate reductase1.5.1.30.468
1o76CAMCamphor 5-monooxygenase1.14.15.10.468
1vzdCB3Thymidylate synthase/0.468
3dfrMTXDihydrofolate reductase1.5.1.30.468
3tqbFOLDihydrofolate reductase/0.468
2fzhDH1Dihydrofolate reductase1.5.1.30.467
2ph5NADHomospermidine synthase/0.467
3sai9DRDihydrofolate reductase/0.467
4p68MTXDihydrofolate reductase/0.467
1culFOKAdenylate cyclase type 2/0.466
1culFOKAdenylate cyclase type 5/0.466
1kmsLIHDihydrofolate reductase1.5.1.30.466
2w3wVG9Dihydrofolate reductase/0.466
4m6kFOLDihydrofolate reductase1.5.1.30.466
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.466
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.465
1kmvLIIDihydrofolate reductase1.5.1.30.464
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.464
2ojg19AMitogen-activated protein kinase 12.7.11.240.463
2ykeYKEHeat shock protein HSP 90-alpha/0.463
3sa16DRDihydrofolate reductase/0.463
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.462
3is9AC7Gag-Pol polyprotein2.7.7.490.462
1s3yTQTDihydrofolate reductase1.5.1.30.461
3i8aN22Dihydrofolate reductase1.5.1.30.460
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
1mvtDTMDihydrofolate reductase1.5.1.30.459
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.459
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
1m7aMQUDihydrofolate reductase1.5.1.30.457
4ixgIXGDihydrofolate reductase1.5.1.30.457
4mv1ADPBiotin carboxylase6.3.4.140.457
4m2xTMQDihydrofolate reductase1.5.1.30.456
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2dhfDZFDihydrofolate reductase1.5.1.30.454
3hv3R49Mitogen-activated protein kinase 14/0.454
1dlrMXADihydrofolate reductase1.5.1.30.453
1eioGCHGastrotropin/0.453
1ohkCOPDihydrofolate reductase1.5.1.30.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
2ykcYKCHeat shock protein HSP 90-alpha/0.453
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.453
5cccDDFDihydrofolate reductase1.5.1.30.453
5hs1VORLanosterol 14-alpha demethylase/0.453
4z34ON7Lysophosphatidic acid receptor 1/0.453
3cgeNDPCoenzyme A disulfide reductase/0.452
1f20FADNitric oxide synthase, brain1.14.13.390.451
2rkvZBATrichothecene 3-O-acetyltransferase/0.451
3ezpB3NHistone deacetylase 83.5.1.980.451
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3g5hYTTMycocyclosin synthase1.14.21.90.451
3tq8TOPDihydrofolate reductase/0.451
4ipw1G7Mycocyclosin synthase1.14.21.90.451
4uymVOR14-alpha sterol demethylase Cyp51B/0.451
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
1l8qADPChromosomal replication initiator protein DnaA/0.450
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.450
3h3sH15Collagen type IV alpha-3-binding protein/0.450
4qa2SHHHistone deacetylase 83.5.1.980.450
1ao8MTXDihydrofolate reductase1.5.1.30.449
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3meeT27Gag-Pol polyprotein2.7.7.490.449
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3sa27DRDihydrofolate reductase/0.449
4pkl1GHUncharacterized protein/0.449
4x5fFOLDihydrofolate reductase1.5.1.30.449
4xe606UDihydrofolate reductase1.5.1.30.449
1dhiMTXDihydrofolate reductase1.5.1.30.448
2w6oOA3Biotin carboxylase6.3.4.140.448
3ghvGHCDihydrofolate reductase1.5.1.30.448
1dajMOTDihydrofolate reductase1.5.1.30.447
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.447
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.447
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.447
4fgg0U5Dihydrofolate reductase1.5.1.30.447
4ia1BIVVitamin D3 receptor A/0.447
4r20AERCytochrome P450 family 17 polypeptide 2/0.447
1m13HYFNuclear receptor subfamily 1 group I member 2/0.446
2vn0TDZCytochrome P450 2C8/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
3d80Q22Dihydrofolate reductase1.5.1.30.446
2w6zL21Biotin carboxylase6.3.4.140.445
4jx1CAHCamphor 5-monooxygenase1.14.15.10.445
1ly3COGDihydrofolate reductase1.5.1.30.444
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.444
3nu03TUDihydrofolate reductase1.5.1.30.444
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4l4fCAMCamphor 5-monooxygenase1.14.15.10.444
2a1mCAMCamphor 5-monooxygenase1.14.15.10.443
2x7hPFNProstaglandin reductase 310.443
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.443
4l8u9AZSerum albumin/0.443
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1dhfFOLDihydrofolate reductase1.5.1.30.442
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1uxjNADMalate dehydrogenase/0.442
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.442
2ejzSAHDiphthine synthase/0.442
3cd2MTXDihydrofolate reductase1.5.1.30.442
3l8sBFFMitogen-activated protein kinase 14/0.442
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.442
3s1dZIRCytokinin dehydrogenase 11.5.99.120.442
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.442
4r21STRCytochrome P450 family 17 polypeptide 2/0.442
1h65GDPTranslocase of chloroplast 343.6.50.441
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3cgdNADCoenzyme A disulfide reductase/0.441
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3p9tTCLRepressor/0.441
4cdmFO1Deoxyribodipyrimidine photolyase/0.441
1osvCHCBile acid receptor/0.440
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.440
1tdrMTXDihydrofolate reductase1.5.1.30.440
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2rf2MRXGag-Pol polyprotein2.7.7.490.440
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.440
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.440
3negPYVAbscisic acid receptor PYL1/0.440
3nj0PYVAbscisic acid receptor PYL2/0.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.440
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440